Eosinophilic disorders

Please click on the links below to read our articles. If you are interested in research findings, click here for links to research reports.

The diary of Marvin (the paranoid android) and Galaxy Glazer (allergic to gluten and dairy) – in their own words.....


Rachel, T1D Mum to an EGID son and a food allergy daughter, explains what Eosinophilic Diseases are and what it is like living with them! February 2016

The Recipe Resource – a useful blog from the mother of a child with EGIDs with a wide range of recipes suitable for very restricted diets. October 2013

Eosinophilic Esophagitis: New Guildines from the American College of Gastroenterology. July 2013

Confounding factors affect the pathophysiology of eosinophilic esophagitis. A review of those factors, the new developments, and new directions in the advancement of knowledge of this disease. Yoram Elitsur, Department of Pediatrics, Gastroenterology Division, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia. September 2012

Eosinophilic gastric disease and helminths. October 2012

Eosinophilic Gut Diseases study day. This full study day for families and for health professionals was put together by the Academy for Paediatric Gastroenterology (APG), the gastroenterology department at Great Ormond Street Hospital (GOSH) and FABED, the support group set up by Amanda Cordell to help other families with children suffering from eosinophilic gastric disorders. September 2012

In 2005 we told the story of two-year-old Samuel who had been diagnosed with the newly recognised eosinophilic gastric disease and who was, effectively, intolerant of all food and many environmental allergens. Samuel's mother, Amanda brings us up to date, along with announcing the first ever conference to be held by FABED, the support group that she founded to help the ever growing numbers of families suffering from eosinophilic disease. July 2012

A new, non-invasive blood test is being developed for eosinophilic esophagitis. Current screening measures involve invasive endoscopies requiring patients to be anesthetized. March 2012

Gabriel's story - a great blog following the daily life of four-year-old Gabriel who suffers from severe allergies, anaphylaxis, asthma, eosinophillic esophogitis and Ehlers Danlos Syndrome. October 2010

Neurofeedback a possible treatment for Eosinophilic Esophagitis. December 2009

Patients suffering from gastroesophageal reflux disease (GERD) may in fact be suffering from eosinophilic esophagitis (EE). From the American Medical News. 2009

Eosinophilic Gastrointestinal Disorders: EGIDs and the story of the first distressing years of Jack's life, and how he, his family and physicians have come to manage his disorders. By Loretta Jay. 2008

Eosinophilic Gastrointestinal Disorders – Tylor’s Case: the story of one boy who dwindled to not much more than skin and bone before doctors realised his immune system was protecting him from food itself. Via MSNBC.com. 2007.

Samuel’s story of total food allergy: a mother’s story of her son, Samuel, who is very probably allergic to all foods and drugs too. 2005

EGIDs – Caitlin and Erin’s stories: two mothers’ stories of their baby girls who suffer from eosinophilic gastrointestinal disorders, and how they have coped over the years.

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Research Reports

Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis. Jan 2018

Allergy tests were performed on over 100 patients with eosinophilic esophagitis. Guided by these results, the patients were treated with elimination diet and/or immunotherapy for personal allergens. 78% of patients showed clinical improvement and this was even greater in those who underwent immunotherapy.

Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis. Oct 2017

Individuals with eosinophilic esophagitis have a higher risk of various atopic diseases such as asthma, rhinitis and dermatitis. This study reports that they are also more likely to suffer from pollen-food allergy syndrome – with one quarter of patients having both conditions.

Oral immunotherapy for peanut allergy induces eosinophilic esophagitis: three pediatric case reports. February 2016

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity. January 2016

Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children. December 2015

This review summarizes the evidence on EoE pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. November 2015

Allergic mechanisms of Eosinophilic oesophagitis. October 2015

Eosinophilic Esophagitis: Another Atopy-Related Alopecia Areata Trigger? November 2015

Management of Eosinophilic Esophagitis in Adults. October 2015

A review of the evidence linking eosinophilic esophagitis and food allergy. Jan-February 2014

Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis. September 2015

Validation of a set of clinical and endoscopic features to predict EoE with a high degree of accuracy and allow identification of those at very low risk of disease. September 2015

Scientists elucidate the role of a key molecule involved in eosinophilic esophagitis (EoE). August 2015

From genetics to treatment of eosinophilic esophagitis. October 2015

Comparison of atopic features between children and adults with eosinophilic esophagitis. October 2014

Oral immunotherapy to egg results in severe eosinophilic esophagogastroenteritis in 9 year old boy. February 2015

Environmental factors such as smoking, breastfeeding, antibiotic exposure, animal exposure etc not found to be relevant in the development of Eisinophilic Esophagitis. June 2015

Eosinophilic gastroenteritis and colitis increasingly frequent in paediatric patients. June 2015

Benefits of an integrated approach by food allergists, gastroenterologists, and pathologists in themanagement of Eosinophilic esophagitis. August 2014

New, non invasive device to diagnose and monitor inflammatory conditions in the gastronintestinal tract (such as EoE and EGE) given the go ahead. January 2015

Four-food group elimination diet successful for adult eosinophilic esophagitis. August 2014

Reviewof the current literature on the sensitization pattern of adult EoE patients and critical discussion of the diagnostic and therapeutic tools available. February 2014

Invariant natural killer T-cell neutralization is a possible novel therapy for human eosinophilic esophagitis. January 2014

Researchers identify four new genes associated with eosinophilic esophagitis (EoE). November 2014

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE. September 2014

The first study to extensively characterize eosinophilic gastritis (EG) found that EG is a systemic disorder that has high levels of eosinophils in the blood and gastrointestinal tract, and has a gene expression pattern (transcriptome) that is distinct from that of a related disorder, eosinophilic esophagitis (EoE). September 2014

A review of the available data on the major types of dietary therapy for EoE, including elemental formula diets, skin allergy testing-directed elimination diets and empirical elimination diets based on common food allergens. January 2014

EoE developed in patients with IgE-mediated food allergy after OIT (oral immunotherapy). September 2014

Environment plays bigger role than genetics in eosinophilic esophagitis. September 2014

Clinical characteristics and sensitivity to food and inhalants among children with eosinophilic esophagitis. January 2014

Elimination diets versus other therapies for EoE. January 2014

Food sensitizations in EoE patients are mainly caused by cross-reactivity to food allergens after primary birch pollen sensitization. November 2013

Adults with eosinophilic esophagitis should consider a diet change. July 2014

New research identifies upregulation of the CAPN14 gene as significant in the development of EoE thereby opening up new potential for treatment. July 2014

Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. July 2014

Classic IgE mediated food allergy can develop into EoE to the same food. March 2014

Symptoms for eosinophilic esophagitis, or EoE and  PPI-responsive esophageal eosinophilia, or PPI-REE are identical but treatments differ: anti-inflammatories for EoE, antacid medications/proton-pump inhibitor (PPI) for PPI-REE.  Antacid trial and endoscopic biopsy needed to differentiate between them. December 2013

Candida albicans and cross-reactive plant allergen components, in particular profilins, often a trigger in adult EoE patients. June 2013

Rare immune cells promote food-induced allergic inflammation in the esophagus, resulting in Eosinophilic esophagitis. July 2013

Update on basic and clinical aspects of eosinophilic oesophagitis. April 2013

Could the elimination of cow’s milk alone be successful in treating eosinophilic esophagitis? December 2012

Individually tailored elimination diets prove helpful for adult patients with eosinophilic esophagitis. December 2012

Empiric 6-food elimination diet induced and maintained (for three years) remission in patients with adult eosinophilic esophagitis. March 2013

A less invasive test for the management of Eosinophilic Esophagitis (EoE). October 2012

Eosinophilic disorders of the gastrointestinal tract: 4 case studies. July 2012

Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. June 2012

Eosinophilic esophagitis linked to master gene. March 2010

Reflux disease may mask eosinophilic oesophagitis. October 2008

Infection with stomach ulcer bug may protect against reflux disease. October 2008

Swallowing difficulties may indicate eosinophilic oesophagitis. October 2008



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