Intense remedial reading training increases brain’s ability to transmit signals

Carnegie Mellon University scientist Timothy Keller and Dr Marcel Just, Hebb Professor of Psychology and director of Carnegie Mellon's Center for Cognitive Brain Imaging , report, in the journal Neuron, that brain imaging of children between the ages of 8 and 10 showed that the quality of white matter -- the brain tissue that carries signals between areas of grey matter, where information is processed -- improved substantially after the children received 100 hours of remedial training. After the training, imaging indicated that the capability of the white matter to transmit signals efficiently had increased, and testing showed the children could read better.

The fact that it is possible to rewire a brain's white matter has important implications for treating reading disabilities and other developmental disorders, including autism.
It has been known for some time that behavioural training can enhance brain function. The breakthrough with this study is detecting changes in brain connectivity with behavioural treatment.

Keller and Just's study was designed to discover what physically changes in the brains of poor readers who make the transition to good reading. They scanned the brains of 72 children before and after they went through a six-month remedial instruction program. Using diffusion tensor imaging (DTI), a new brain imaging technique that tracks water movement in order to reveal the microscopic structure of white matter, Keller and Just found a brain change involving the white matter cabling that wires different parts of the brain together.
Water molecules that are inside nerve fibers tend to move or diffuse parallel to the nerve fibres. To track the nerve fibers, the scanner senses areas in which many water molecules are moving along in the same direction and produces a road-map of the brain's wiring.

Previous DTI studies had shown that both children and adults with reading difficulty displayed areas of compromised white matter. This new study shows that 100 hours of intensive reading instruction improved children's reading skills and also increased the quality of the compromised white matter to normal levels. More precisely, the DTI imaging illustrated that the consistency of water diffusion had increased in this region, indicating an improvement in the integrity of the white matter tracts.

The improved integrity essentially increases communication bandwidth between the two brain areas that the white matter connects, by a factor of 10 opening a new era of being able to see the brain wiring change when an effective instructional treatment is applied.

For a fuller report

Journal Reference:
Timothy A. Keller, Marcel Adam Just. Altering Cortical Connectivity: Remediation-Induced Changes in the White Matter of Poor Readers. Neuron, 2009; 64 (5): 624-631


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First Published in December 2009

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