Mixing antihistamine with fruit juices may reduce their efficacy

Antihistamine ‘Allegra’, which contains the drug fexofenadine, should not be taken with fruit juice – although currently there is only data on grapefruit, orange, apple and cranberry. Allegra is an antihistamine, and as with any drugs, antihistamine or other, one should pay attention to what it is swallowed with. The only effect of taking fexofenadine with fruit juice is a little less effectiveness of the drug – there is no deadly outcome.

This understanding is partly based on a study carried out by researchers at the University of Western Ontario, London, Ontario, Canada. Their objective was to examine the effects of different fruit juices on P-glycoprotein and organic anion transporting polypeptide (OATP) performance on drugs in humans. The results showed that fruit juices can inhibit performance, calling for a new model of intestinal drug absorption and research into the mechanism of food-drug interaction.

Source: Clinical Pharmacology and Therapeutics

First published in June 2012

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