|
IgG and Gastrointestinal Disorders |
Dr Anton Emmanuel, consultant gastroenterologist and senior lecturer in neuro-gastroenterology at University College Hospital, London, outlines some of his recent work. Additions in italics in brackets are intended to help our less medically literate readers to understand Dr Emmanuel - they might also be helped by reading our article on allergy testing. |
The possible role of food hypersensitivity in causing gastrointestinal disease was first suggested in 1950. While there is good evidence of the clinical importance of food allergy in certain gut diseases (eosinophilic enteritis, coeliac disease), the role of gastrointestinal hypersensitivity (allergic) reactions in other gut disorders remains controversial. Antibody combinations Disodium cromoglycate inhibits the release of inflammatory mediators by inhibiting degranulation of mast cells (prevents the release of histamine etc) following contact with an allergen. Hence, the effect of this drug in IBS may be due to the curtailment of an allergen-mediated response. A larger study of 428 patients comparing disodium cromoglycate and elimination diet demonstrated that disodium cromoglycate was as effective as an elimination diet in improving symptoms. First published in 2007 • If this article was of interest you will find many other articles on unlikely allergies and allergy connections here – and links to many relevant research studies here.
|