Pulmonary involvement and allergic disorders in inflammatory bowel disease

Pulmonary involvement and allergic disorders in inflammatory bowel disease
Nikolaos E Tzanakis, Ioanna G Tsiligianni, Nikolaos M Siafakas
World J Gastroenterol 2010 January 21; 16(3): 299-305


Inflammatory bowel disease (IBD) has been asso ciated with either clinical or subclinical airway and parenchymal lung involvement and interstitial lung complications. Several studies have reported that atopy has a high prevalence in IBD patients. Overlapping allergic disorders seem to be present in both the respiratory and gastrointestinal systems. The purpose of this review is to update clinicians on recent available literature and to discuss the need for a highly suspicious approach by clinicians.

Three patterns of pulmonary involvement have been reported to accompany IBD: (1) airway disease includ ing large airway stenosis, chronic bronchitis, small airway dysfunction, severe bronchial suppuration and bronchiectasis; (2) parenchymal lung involvement either as subclinical lymphocytic alveolitis or several types of pulmonary infiltrate such as granulomatous bronchiolitis and bronchiolitis obliterans; and (3) a reduction in the diffusing capacity of the lung is a well established abnormality of pulmonary function testing in some patients with IBD.
We propose that patients suffering from IBD should undergo pulmonary evaluation which should include physical examination, chest X-ray and pulmonary function testing with DLCO measurement. This pulmonary evaluation may be useful in detecting subclinical or clinical pulmonary involvement in IBD patients or as a baseline evaluation. In clinical cases with pulmonary manifestations, inhaled or systemically administered steroids appear to be an effective treatment. With regard to atopy, routine investigations should be considered, at least in patients with IBD who also present with airway dysfunction.

For the full review

Click here for more research on IBD

First Published in 2010

Top of page

If you found this article interesting, you will find many more general articles and research reports on coeliac disease here, and lots of information on the management of coeliac disease here.
You can also find articles and research reports on gluten intolerance here and articles on a wide range of other digestive conditions here.

For hundreds of gluten free foods see our freefrom food section here, and for nearly 800 gluten-free recipes see here.

And if you would like to get our FREE fortnightly e-newsletter with new products, recipes, articles and all the latest news from the allergy and freefrom world, just sign up here.