Research reports on coeliac disease and its causes
Celiac disease, non celiac gluten sensitivity and wheat allergy: comparison of 3 different diseases triggered by the same food. June 2017
This article (full-text available) provides an interesting review of the differences and similarities between these three different types of food sensitivity to wheat and gluten. Its aim is to provide a summary for primary health care professional to aid their recognition of these relatively common conditions.
Coexistence of celiac disease & type 1 diabetes mellitus in children. Jan 2017
This research suggests a higher prevalence of type 1 diabetes in children with coeliac disease than in children without coeliac disease and suggests that regular screening should take place to pick up any cases as soon as possible.
Retrospective evaluation of pregnant women with celiac disease. March 2017
This study looked at the impact of coeliac disease on pregnant women. The presence of coeliac disease was found to be associated with a greater risk of miscarriage and premature births in mothers with coeliac disease. The importance of maintaining a gluten-free diet throughout this period is discussed.
Neurological manifestations of atypical celiac disease in childhood. April 2017
Learning disorders such as epilepsy, attention deficit hyperactivity disorder, and headaches could be the initial neurological manifestations of atypical CD. Eliminating gluten from the diet may improve neurological complaints, epileptic discharges, and neuropsychiatric symptoms in such patients.
Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study May 2017
Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders including: mood disorders, anxiety disorders, eating disorders, behavioural disorders, ADHD, ASD, and intellectual disability. More research is needed to determine factors which may underlie this co-occurrence.
Validation of Antibody-based Strategies for Diagnosis of Pediatric Celiac Disease Without Biopsy. April 2017
This study found that blood tests are highly predictive of biopsy results in children tested for coeliac disease.
Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy? April 2017
This study demonstrates a significant association between blood serum levels of tTG and duodenal biopsy results in patients with coeliac disease. If these results are replicable, biopsy may not always be necessary in patients who have significant symptoms of the disease.
Coeliac disease: further evidence that biopsy is not always necessary for diagnosis. June 2017 (Epub ahead of publication)
More evidence that duodenal biopsy may not be necessary for the diagnosis of coeliac disease. When blood levels of IgA tTG were above a certain level (45 U/ml ) the predictive value of coeliac disease was100%. This had led to modifications in diagnostic guidelines in the Royal Derby Hospital, UK.
Coeliac Disease and Gastrointestinal Symptom Screening in Adult First-degree Relatives. April 2017
A significant number of adult first-degree relatives, of individuals with coeliac disease, demonstrated duodenal changes and/or gastrointestinal symptoms, even when blood tests for coeliac disease were negative.
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. April 2017
Interesting consideration of how contracting a particular reovirus, alongside exposure to a potential allergen (such as gluten or egg), can trigger an intolerance to these foods. The effect the reovirus exerts on T-cells is thought to mediate this response.
Gluten-induced cognitive impairment ("brain fog") in coeliac disease. March 2017
This article reports information regarding cognitive symptoms associated with brain fog in patients with coeliac disease. The researcher asserts that these symptoms have a scientific basis and that they resolve with a gluten-free diet. However, the exact mechanism by which brain fog may come about is poorly understood.
Coeliac disease in the 21st century: paradigm shifts in the modern age. March 2017
This article discusses the many changes in the presentation and diagnosis of coeliac disease that have occurred in recent years. Malnutrition and malabsorption used to be key defining factors but coeliac disease now affects as many overweight individuals as those who are underweight. The increasing incidence of the disease is also discussed, along with the issue of dealing with people with minimal symptoms who have been diagnosed with the condition.
Coeliac disease: a unique model for investigating broken tolerance in autoimmunity. Nov 2016
Interesting review article explaining that we know lots about the many of the steps involved in the development of Coeliac Disease. Despite this wide knowledge, surprisingly little is still known about how and why tolerance to gluten might break down in the first place.
The progression of coeliac disease: its neurological and psychiatric implications. Dec 2016
This review articles explains the possible neurological consequences of Coeliac Disease and highlights some common psychiatric symptoms that occur in untreated Coeliac Disease: depression, schizophrenia and anxiety. A gluten-free diet plays an important role in reducing neurological and psychiatric complications.
Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis. December 2016
This study reports an increased risk of Thyroid Disease in patients with Coeliac Disease, suggesting that it may important to screen patients with Coeliac Disease for thyroid problems. The authors suggest that the effect of a gluten-free diet on Thyroid Disease requires further investigation.
Is there a relationship between gluten sensitivity and postural tachycardia syndrome? (Abnormal increase in heart rate that occurs after sitting up or standing causing dizziness or fainting) Dec 2016 (Epub ahead of print)
This study found a higher incidence of both coeliac disease and self-reported gluten-intolerance in patients with postural tachycardia syndrome (PoTS). It is the first study to propose a relationship between gluten sensitivity and PoTS, suggesting future research into the co-occurrence of these conditions is necessary.
Patients with celiac disease may have normal weight or may even be overweight. Only one third of patients with CD in this study had a low BMI. February 2016
The coexistence of coeliac disease and ulcerative colitis is extremely rare in childhood. However, ulcerative colitis should be considered in coeliac children on restrictive gluten-free diet with persistent diarrhoea or bleeding from lower gastrointestinal tract. January 2016
More than 50% of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry. April 2016
Identification and molecular characterization of oat peptides implicated on coeliac immune response. Febuary 2016
A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands. January 2016
Different Gene Expression Signatures in Children and Adults with Celiac Disease. Febraury 2016
The opioid effects of gluten exorphins: asymptomatic celiac disease. November 2015
Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011-2012. January 2016
Changes in gut microbiota may lead to activation of an inflammatory pathway and thereby to coeliac disease. January 2016
Celiac disease and fibromyalgia: Is there an association? 'We concluded that searching for CD in FM patients is not cost-effective and that this workup should be reserved only for those with any other clue to these gastrointestinal diseases.' February 2016
The neurological manifestations of CD and NCGS are similar and equally responsive to a GFD suggestive of common pathophysiological mechanisms. February 2016
Celiac disease prevalence is doubled in patients with chronic headache. December 2015
Association of ADHD and Celiac Disease: no conclusive evidence. January 2016
Apparently asymptomatic sufferers of coeliac diseases very often develop diseases that can be related with gluten intake. Gluten can be degraded into several morphine-like substances – gluten exorphins. These compounds have proven opioid effects and could mask the deleterious effects of gluten protein on gastrointestinal lining and function. November 2015
Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016
Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification. January 2016
Rare association of celiac disease with myasthenia gravis in a patient with other immune disorders: A case report. January 2016
Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016
Frequency of Celiac Disease in Patients With Increased Intestinal Gas (Flatulence). October 2015
High prevalence of celiac disease among first-degree relatives of Indian celiac disease patients. November 2015
Researchers find link between processed foods and autoimmune diseases. December 2015
Celiac disease manifest as a neurologic condition in 10% of all CD patients. The most common are cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression and cognitive deficiencies. A review. November 2015
A study of more than 2,700 mothers of children with autism shows that about one in 10 mothers have antibodies in their bloodstream that react with proteins in the brain of their babies possiby causing autism.
Studies suggest that women with certain pro-inflammatory conditions—such as rheumatoid arthritis and celiac disease—are at greater risk of having children with autism. August 2015
Early feeding practices seem to have no impact on the risk of developing CD during childhood. November 2015
A review of complexity of the cereals from which gluten is derived, the special properties of gluten which make it so widely used in the food industry, the basis for its toxicity in CD patients and the potential for the development of safe gluten and alternatives to the gluten-free diet. November 2015
The advent of next-generation assays for diagnosis may result in more sensitive screening and ultimately the possible replacement of the intestinal biopsy as the gold standard for celiac disease diagnosis. 2015
Feeding at-risk infants gluten increases risk of developing celiac disease. November 2015
There is currently no evidence to support that early introduction of gluten to the infant diet increases the risk of CD; however, late introduction of gluten may be associated with increased risk of CD. October 2015
The Spectrum of Differences between Childhood and Adulthood Celiac Disease. October 2015
Can genetic background alone explain the association between coeliac disease and autoimmune diseases or should gluten-related factors be considered? October 2015
The wheat proteins and molecules produced during digestion of bread and pasta can survive digestion and potentially pass through the gut lining suggesting that they could have a biological effect. Previous research has been done on pure gluten rather gltuen-containing foods. July 2015
Spouses & relatives of celiac disease patients at risk for autoimmune diseases. July 2015
Researchers at the Univeristy of Oslo suggest that coeliac disease is caused by the T-cells of those genetically predisposed to suffer from coelaic disease mistaking gluten for a virus and initiating an immune reaction. June 2015
Could rise in the incidence of celiac disease have been caused by the extensive use of the chemical glyphosphate on wheat crops? November 2013
Should anyone showing signs and symptoms of the Coeliac Disease be tested and should screening everyone in high-risk groups be considered? April 2014
The genotype of infants at family risk of developing Coeliac Disease, carrying the HLA-DQ2 haplotypes, influences the early gut microbiota composition. This finding suggests that a specific disease-biased host genotype may also select for the first gut colonisers and could contribute to determining disease risk. June 2014
Study suggests that coeliac disease is significantly more common among white Americans than among Hispanics and African Americans although the latter are very likely to adopt a gluten-free diet. March 2015
Growth screening could help detect coeliac disease in children. March 2015
No link found between when the children were introduced to gluten and their risk of developing celiac disease. January 2015
Could Non-Celiac Gluten Sensitivity trigger gut dysbiosis, neuroinflammation, gut-brain axis dysfunction, and vulnerability for dementia? February 2015
Further research into the possible link between coeliac disease and infertility. February 2015
Diagnosis of CD in children over 2 has tripled over the last 20 years, but diagnosis 80% higher among children in least socio-economically deprived areas than in the most socio-economically deprived areas. January 2015
Fingerprints can predict gluten sensitivity. January 2015
Symptoms and diagnosis of coeliac disease have changed markedly over the last 25 years. November 2014
Celiac disease does not increase clinical consultations for fertility problems. December 2014
Dysbiosis of microbiota is associated with persistent gastrointestinal symptoms in treated celiac disease patients and open new possibilities to treat this subgroup of patients. November 2014
Researchers identify why some people with celiac disease show an immune response after eating oats. Novmeber 2014
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange. November 2014
Celiac disease triggers may include non-gluten proteins. November 2014
Coeliac disease does not increase the risk of death from cancer. Report here. 2014
Early gluten exposure no protection against celiac disease. October 2014
Delaying the introduction of gluten-containing foods to babies at risk for celiac disease doesn't prevent the condition from developing in those children, nor does breastfeeding prevent it. September 2014
Diversity of the cultivable human gut microbiome involved in gluten metabolism: isolation of microorganisms with potential interest for coeliac disease. March 2014
More than 25% of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. July 2014
Gluten sensitivity is commonly self-reported with symptoms suggesting an association with irritable bowel syndrome. The majority of patients have NCGS, not coelaic disease. January 2014
Aphthous-like ulcers are a risk indicator for coeliac disease, and a gluten-free diet ameliorates ulcers. February 2008
Differentiating between celiac disease (CD) and non-celiac gluten sensitivity (NCGS): a diagnostic algorithm. May 2014
Fourfold increase in rate of diagnosed cases of coeliac disease in the UK. May 2014
Study aims to isolate and characterise the human gut bacteria involved in the metabolism of gluten proteins. May 2014
Increased prevalence of celiac disease in children with irritable bowel syndrome. April 2014
Elafin, a human protein, plays a key role against the inflammatory reaction typical of coeliac disease. Researchers have developed probiotic bacterium to deliver Elafin to the gut of mice. Comment in Science Daily. April 2014
Coeliacs may have a near two-fold increased risk of coronary artery disease compared with the general population. March 2014
Chronic intestinal damage raises hip-fracture rate in celiac disease patients. January 2014
Celiac disease Is diagnosed less frequently in young adult males. January 2014
Autoimmune diseases such as coeliac disease, rheumatoid arthritis, MS, Crohn’s, lupus and colitis appear to arise out of small DNA changes located outside the genes themselves. December 2013
Coeliac disease more common in children with higher socio-economic status although this may be party due to more frequent diagnosis amongst this group. November 2013
Decreased risk of celiac disease in patients with Helicobacter pylori. October 2013
Nationwide Swedish study finds no association between CD or inflammation and earlier Autistic Spectrum Disorders, there was a markedly increased risk of ASDs in individuals with normal mucosa but a positive CD serologic test result. September 2013
People with celiac disease whose intestines are slow to heal could be at increased risk of cancer of the immune system, or lymphoma. August 2013
Antibiotic exposure has positive association with the development of coeliac disease. 2013
Combining gene tests with blood tests could increase the accuracy and reduce the need for invasive diagnostic tests for coeliac disease. Research here; comment here. August 2013
Coeliac disease, originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now equally common in all these countries. It is still thought to be rare in the Orient and Sub-Saharan Africa although wheat consumption there is now of the same order as in Western Europe so CD may become more common in the future. August 2013
Neuro, gut and thyroid disorders common in coeliacs despite GF diet. Comment here. July 2013
Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. May 2013
Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. May 2013
Patients who had previously been prescribed antisecretory medications, including proton pump inhibitors and histamine-2 receptor antagonists at increased risk for developing celiac disease. May 2013
75% of coeliacs have lower bone mineral density. May 2013
Prevalence and natural history of potential celiac disease in adult patients. March 2013
Glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins – result – most of the diseases and conditions associated with a Western diet such as coeliac disease, autism, cancer and Alzheimer’s disease. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. January 2013
Oral and dental issues such as enamel defects and mouth ulcers may be an indication of coeliac disease. December 2012
New research indicates that repeated infections early in life increase the risk of developing coeliac disease. It is not known whether the problem is the infections themselves or the antibiotics frequently prescribed to treat them, antibiotics being known to seriously disrupt the gut microbiome. December 2012
Gluten-free diet reduces weight gain, inflammation and insulin resistance in mice. December 2012
Introducing small amounts of gluten along with breastfeeding from four months onwards appears to reduce the incidence of coeliac disease at the age of 12. November 2012
Migraine more prevalent in those with coeliac disease and inflammatory bowel disorders so it would be prudent to screen migraineurs for CD. November 2012
Although coeliac disease is associated with a small increase in the risk of bone fracture and malignancy (the latter in the first year after diagnosis), it is also associated with a marked reduction in the risk of breast and lung cancer. October 2012
Undiagnosed coeliac disease can often be a cause of dysmotility, indigestion and IBS. October 2012
Genetic testing an important tool to identify first degree relatives who may be susceptible to coeliac disease. October 2012
Screening blood from 4,000 healthy blood donors in Brazil showed that one in every 286 subjects had indiagnosed coelaic disease, of whom 67% were of European origin. September 2012
ESPGHAN diagnostic criteria work well in selected population. November 2012
Brain abnormality in patients with coeliac disease. August 2012
Frequency of coeliac disease in Asians. August 2012
Persistent bone pain may be a sign of coeliac disease. March 2012
Maternal antibodies to gluten linked to schizophrenia risk in children. May 2012
Goblet cells in the intestine may play a much more important role than had been thought in the transport of potential allergens to dendritic cells which, in turn, spark immune system allergic and autoimmune reactions in inflammatory bowel disease, coeliac disease and allergies. April 2012
Could maize/corn be as damaging for coeliacs as wheat? February 2012
High prevalence of coeliac disease among first degree relatives of coeliac patients. January 2012
Capsule endoscopy increasingly used to diagnose coeliac disease because it is non-invasive and provides a close and magnified view of the mucosa of the entire small bowel. An update of current data. January 2012
Gluten contamination in the Canadian commercial oat supply.
Information on gluten-containing cosmetics is not so easy to find. October 2011
Influence of breast milk versus formula and genetics on gut microbiota composition could help prevent coeliac disease.
Genetic study sheds light on auto-immune arthritis which may have relevance for coeliac disease. July 2011
Could coeliac disease be implicated in some deaths from childhood diarrhoea?
Spring/summer born children more likely to have coeliac disease. May 2011
In adults with coeliac disease, intestinal damage doesn’t always heal. March 2011
Mouse study suggests new chemical clues to coeliac disease. February 2011
The prevalence of coeliac disease in Europe: results of a centralised, international mass screening project. December 201
Increased risk of thyroid cancer in coeliac patients. August 2010
Saliva test for coeliac disease successful. November 2010
Coeliac patients in Sweden at greater risk of influenza hospital admission. September 2010
Elderly people more likely to develop coeliac disease than children. September 2010
Family stress does not appear to be a cause of childhood coeliac disease. September 2010
IBS patients have signficantly higher risk of being coeliac than those who do not suffer from the condition. December 2009
Toxic fragments in gluten which cause coeliac disease finally identified. July 2010
Viral infections may be implicated in coeliac disease. July 2010
Can coeliac disease cause infertility?
Does a Caesarean delivery increase a child’s risk of becoming coeliac? May 2010
Blood tests provide accurate diagnostic alternative to biopsy in coeliac disease.
Short stature of coeliac disease children linked with pituitary abnormality. March 2010
Cystic fibrosis is a risk factor for coeliac disease. March 2010
Gluten intolerance doubles in Finland. No suitable criteria for diagnosis exist, says Finnnish expert. March 2010
Coeliac disease could originate in a viral infection. March 2010
Five simple questions to find hidden coeliac disease in children. February 2010
Recurrent infections in small children could be caused by silent coeliac disease. February 2010
Rate of coeliac diagnosis has increased since introduction of antibody test.
More research suggests that coeliac disease can shorten lifespan.
Immune system found to attack bone tissue in coeliacs.
Coeliac disease four times more common than in 1950s and, if undiagnosed, four times more likely to kill you... October 2009
Mouth ulcers a possible indication of coeliac disease. October 2009
Increasing prevalence and high incidence of coeliac disease in elderly people.
Coeliac disease and B vitamins. April 2009
Coeliac disease and anaemia.
Coeliac disease and Type 1 diabetes share some gene variants.
Nine coeliac gene regions identified, four of which predispose to type 1 diabetes. September 2008
The botany of gluten.
Coeliac disease increases TB risk.
Some infections may increase childhood coeliac risk.
Integrative Manual Therapy (IMT) for gluten sensitivity. February 2007
Possible relationship between myopathies and coeliac disease. February 2007
Potential coeliac disease/dementia link discovered.
Is there a link between coeliac disease and Inflammatory Bowel Disease? July 2006
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