New research reports are collated for us by Kate Lawrence, a psychologist working at St Mary’s University, Twickenham, where her research focuses on social and emotional development in children and the influence of diet and nutrition on physical and emotional well-being.
10th August 2018
This study looked at 72 children who were allergic to grass pollen. It was found that 60% of these children were also sensitised to wheat.
Dupilumab is a relatively new biological drug aimed at treating allergic diseases such as asthma and atopic dermatitis. This review article considers the research evidence supporting its use and reflects on its efficacy and safety. Full article available.
This study compared the prevalence of allergies between data from 2005 and 2015 in Spain. During this decade there was a statistically significant increase in incidences of allergic rhinitis, food allergy and drug hypersensitivity. In addition to this, the number of allergens individual patients reacted to was also found to have increased. Full article available.
This study looked at the in vitro response (within a laboratory) to the blood of peanut allergic patients when combined with a prebiotic mixture (non-digestible oligosaccharides). The prebiotic mixture was found to contribute to decreased degranulation of basophils in vitro in peanut-allergic patients. This suggests future research should investigate the potential for using prebiotics to reduce allergic symptoms in patients with allergies. Full article available.
Food allergy and anaphylaxis. June 2018
An interesting review article focusing on the current state of our understanding of food allergy and anaphylaxis. It discusses signs and symptoms, short-term treatment and long-term management. Full article available.
This article considers why epinephrine (often given as an Epi-Pen or Jext injection) is still an underutilised treatment for anaphylaxis. Understanding why this is so is an important step in tailoring education interventions to ensure it is used whenever appropriate. Full article available.
21st July 2018
This thorough review article considers the evidence for microbiome associations in different diseases. Unsurprisingly allergies and autoimmune diseases feature heavily. Associations between the microbiome and a range of prescription medications were also noted. Full article available.
Association of Early Introduction of Solids with Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial. July 2018 This study re-analysed some of the data collected in The Enquiring about Tolerance food allergy clinical trial which took place at St Thomas’ Hospital, London.
Eating Worms to Treat Autoimmune Diseases? July 2018 This clearly written article is published in Frontiers for Young Minds, a science journal aimed at children. It describes, with beautiful simplicity, the research and explanations behind the use of parasitic worms as a treatment for autoimmune disorders and allergies. One way parasites might exert their therapeutic effect is through the activation of T-regulatory cells – these may help the individual avoid over-responding to ‘safe’ things that they are exposed to such as allergens.
This research was conducted on over 200 children with ADHD and over 200 control children without the condition. It was found that ADHD was associated with allergic symptoms (such as asthma, rhinitis and eczema) and haemoglobin levels. This raises the question as to whether allergies may precede ADHD and in some way contribute to its development or whether both allergies and ADHD share a common aetiology. Understanding the role inflammation may play in this association could be key to understanding more about any mechanisms. Full article available.
Debates in Allergy Medicine
These two studies (full articles available) consider the arguments for and against the success of oral immunotherapy for treating milk and egg allergy. The pro argument suggests that 21-58% of individuals undergoing oral immunotherapy for milk or egg achieve tolerance to these foods. The con argument suggests that these individuals may have achieved tolerance anyway. June 2018
4th July 2018
A 3 year study in adults with a physician-confirmed diagnosis of food allergy just under 50% reported accidental allergic reactions, the highest number being to peanut, milk and sesame. Eight different allergens not declared on the ingredient lists were also detected in the culprit food products.
The LEAP Study demonstrated that the early consumption of peanut in high-risk infants successfully reduced the prevalence of peanut allergy at five years of age when compared to peanut avoidance. This further follow-up of the study participants will assess whether the benefits of regular early-life peanut consumption are maintained over many years when followed by consumption of peanut ad lib, or as much and as often as desired.
22nd June 2018
Some really promising results from a small scale, open-label, clinical trial using a modified ketogenic diet in children with autism spectrum disorder. Significant improvements were noted in a number of aspects of autistic behaviour. Full report available.
This study reports that whilst 20% of children may have adverse symptoms to milk early in life, by age 16, this figure has reduced to 2%. Full article available.
In mice, it is suggested that administration of a specific probiotic (during early life) might be beneficial in reducing the risk of igE mediated allergies developing in later life.
A worrying statistic that 40% of college students do not consistently carry their emergency medication.
The Rise and Rise of Eosinophilic Gut Diseases Including Eosinophilic Esophagitis Is Probably Not Explained by the Disappearance of Helicobacter pylori, so Who or What's to Blame? June 2018
This review considers the rise in recent years in both eosinophilic gut disease and allergies more generally. It is postulated that some of the reasons for this might be a shifting microbiome, antibiotic use and diet and lifestyle factors.
10th June 2018
An article (full-text available) reviewing the important role of an intact gastrointestinal wall in preventing food allergy development. Importantly anti-ulcer medication was also found to increase the risk of food allergy reactions.
Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and are Clinically Relevant to the Pathogenesis May 2018
An interesting report exploring food specific IgGs in patients with inflammatory bowel disease. In patients with Crohn’s, food specific IgGs were significantly elevated. Moreover, these IgG levels were found to be moderated by a typical drug treatment for Crohn’s.
A consideration of the effect of global warming on the concomitant rise in allergic diseases. It is discussed how the warmer, moist environment encourages common allergens such as pollens, dust-mite, moulds and fungi. The importance of biodiversity is also explored.
A Specifically Designed Multispecies Probiotic Supplement Relieves Seasonal Allergic Rhinitis Symptoms. May 2018 More than half of the hay fever sufferers taking part in this study experienced a marked improvement in quality of life following probiotic treatment.
Limiting Dietary Sugar Improves Pediatric Sinonasal Symptoms and Reduces Inflammation May 2018 Thought provoking preliminary research reporting that a reduction in sugar intake is associated with a reduction in inflammatory markers and nasal congestion.
Helminth-induced regulatory T cells and suppression of allergic responses Oct 2018 (epub ahead of print)
This review article considers animal research and clinical trials looking at the influence of helminths (therapeutic parasitic worms) on immune function. In particular, their promising role in treating allergic inflammation is considered. Original research here.
26th May 2017
This review considers various nutritional interventions which may be useful for the prevention of food allergy, for example: breastfeeding; early introduction of highly allergenic foods; probiotics, prebiotics, omega 3 and vitamin D. Full text available. Treatment options are also reviewed.
Recent changes in the management of patients with food allergy in a tertiary referral centre: A Dietitian's perspective May 2018
A consideration of some of the changes, in recent years, in advice given to patients for their management of food allergy. Examples include early introduction of baked milk and egg products and encouraging the consumption of other nuts in children who are allergic to one or two types.
Review of some emerging therapies that may prove useful as immunotherapy strategies, including: probiotics, helminths (parasitic worms) and Vitamin D. Full article available.
This laboratory experiment explored the role of green tea in the inflammatory markers and cell permeability triggered by gluten. It was found that green tea reduced cell permeability and the release of inflammatory markers. The authors suggest green tea may be a useful additional therapy for patients with coeliac disease.
An interesting case study of an individual patient who reported a profound improvement in fibromyalgia symptoms following a novel dietary protocol. Full article availiable.
12th May 2018
Evidence that a Mast Cell Activation test may be a more accurate method of diagnosing food allergies. Full text available. Guardian article here.
This research looked at the composition of bacteria sampled from the mouth during infancy and at seven years of age. It was found that children who developed allergies had a very different oral bacteria composition to non-allergic individuals.
Fecal Microbiome Signatures are Different in Food Allergic Children Compared to Siblings and Healthy Children. April 2018 It was revealed that the microbiome (gut bacteria) of food allergic children was markedly different to children without food allergies.
The Nuts and Bolts of Food Immunotherapy: The Future of Food Allergy. April 2018
Interesting full-text review article about the current state of the research into food immunotherapy.
Current perspectives on tree nut allergy: a review. March 2018
Interesting full-text review article about the current state of the research into tree nut allergy.
The Southern Sweden Adolescent Allergy-Cohort: Prevalence of allergic diseases and cross-sectional associations with individual and social factors. April 2018
This study looked at a group of 1500 adolescents in Sweden and reported the incidence of different types of allergic disease in these individuals. 32% reported at least one allergic disease, including 12% who reported food sensitivity.
28th April 2018
Full-text review article looking at the latest state of the research on vitamin D and food allergy. Consideration is paid to how vitamin D may interact with the immune system and the possible role of gut bacteria in the process.
A review considering the importance of appropriate dietary management in children avoiding dairy products due to cow’s milk allergy.
This review article considers the way in which environmental chemicals may enhance sensitisation to plant allergens by increasing their expression and altering their ability to provoke an immune response.
Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays. March 2018
A review of food allergen detectors.
An interesting consideration of food allergies from an evolutionary perspective. It is considered that possibly a mismatch between foods babies are exposed to during gestation and infancy and those that are eaten later on could be problematic for the development of immunity to these food proteins. Full text.
This review study suggests that many factors are associated with prognosis of food allergy, for example, ethnicity, sex and gut bacteria. It also considers the use of immunotherapy and biologics as treatments for persisting allergies.
14th April 2018
This study was carried out on mice who had genetic skin barrier deficits. When the mice had their skin briefly exposed to food and environmental allergens at the same time, they were at an increased risk of allergic reaction, including anaphylaxis. Interestingly these allergic responses were inhibited if the mice had previously been exposed to the food allergen orally.
This review argues that skin dysfunction in early infancy, combined with an imbalance of gut bacteria might be necessary for development of subsequent atopic conditions, such as asthma and food allergies. Full text.
Children with a family history of food allergies and intolerances were prevalent in a group of children who had difficulties getting to sleep and suffered from frequent nocturnal awakening.
Some interesting thoughts on the role of preventative medicine in targeting children at high risk of developing food allergies. Full text available.
Up-to-date considerations of the management of food allergy within educational settings.
When undergoing oral food challenges, there was a higher risk for developing more severe symptoms in patients who had higher specific immunoglobulin E (sIgE) levels to the particular allergen being trialled.
31st March 2018
This study of 1,400 twins in Sweden found that depression or anxiety tended to occur together in families where one or more twin had atopic disease. They report a familial association between allergies and depression and anxiety which does not seem to be explained by genetic factors. Other explanations, such as the environment must be considered.
The ingestion of probiotics, according to this research, may play more of a role in preventing allergies in older children than in infants.
Allergic rhinitis. Jan-Feb 2018
This article considers the importance of understanding individual symptoms and triggers for the best management of allergic rhinitis.
Asthma associated to rhinitis. Jan-Feb 2018
Patients with asthma and rhinitis are found to have more severe asthma symptoms and decreased quality of life compared to patients with asthma alone.
It was found that there was an increased risk of asthma in the offspring of mothers and grandmothers who smoked during pregnancy and also of fathers who smoked as adolescents.
This cross-sectional study of adolescents in Brazil found that environmental tobacco smoke exposure was associated with a higher risk of asthma symptoms. Additionally it was found that exposure to animals in the first year of life was also found to be associated with asthma symptoms, although other studies suggest early exposure to animals may be associated with a decreased risk of developing allergies.
Relationships between Second-hand Smoke Incursion and Wheeze, Rhinitis, and Eczema Symptoms in Children Living in Homes without Smokers in Multi-Unit Housing. March 2018
An interesting consideration of second hand smoke inhalation in multi-unit housing and the association of this with wheeze, rhinitis and eczema.
18th March 2018
Short-course of grass allergen peptides immunotherapy over three weeks reduces seasonals
ymptoms in allergic rhinoconjunctivitis with/without Asthma: A randomized, multicenter, double-blind, placebo-controlled trial. March 2018
Subcutaneous immunotherapy with grass allergen peptides for just three weeks was found to reduce hay fever allergic symptoms.
Impact of acupuncture on antihistamine use in patients suffering seasonal allergic rhinitis: secondary analysis of results from a randomised controlled trial. Feb 2018
A randomised controlled trial reports reduced use of antihistamines in patients with seasonal allergic rhinitis treated with acupuncture.
The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. Jan 2018
Interesting report on the allergens causing allergic rhinitis and the symptoms associated with this.
Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score Jan 2018
Loratadine is a non-sedating second-generation antihistamine. How fast do Loratadine tablets work? This study reports it takes 75 minutes to reduce nasal and eye symptoms of allergic rhinitis.
The Association between Maternal Stress and Childhood Eczema: A Systematic Review. Feb 2018
This review reports a positive association between a mother’s experience of stress whilst pregnant and the development of eczema in her infant.
Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis. Feb 2018
The findings of this review suggest an association between maternal diet and childhood risk of allergic or autoimmune disease. Supplementation with probiotics and fish oils during pregnancy may reduce the risk of the development in the infant of eczema and food allergies.
2nd March 2018
A dietary pattern high in vegetables and grains and low in refined cereals and sweet drinks was associated with a lower risk of going on to develop Coeliac Disease.
A review of some of the potential therapies for coeliac disease. It is suggested that the one which shows the most promise currently is using a vaccine to induce tolerance.
In this study of 255 patients with coeliac disease and 250 controls, autoimmune disorders were more common in the patients with coeliac disease. Full text available.
This review considers the research around the high proportion of children who develop new food allergies after receiving a liver transplant.
An interesting study on mice which states that consuming collagen-derived peptides could alter allergic responses. A promising study that suggests a potential clinical application of these peptides.
An intriguing consideration of how greenhouse gases, the warming climate and extremes in weather may influence allergies.
17th February 2018
The ketogenic diet was trialled in an open study of 15 children with autism spectrum disorder (ASD). This is a diet low in carbohydrates and high in fat. Children’s core symptoms of ASD dropped significantly over the 3 month period.
Intestinal worms eating neuropsychiatric disorders? Apparently so. Feb 2018
This article discusses the relationship between the disruption of gut bacteria (microbiota), inflammation and neuropsychiatric disorders. It puts forward research looking at the therapeutic role helminths may play in regulating the gut bacteria and alleviating symptoms of neuropsychiatric disorders such as depression, chronic fatigue, anxiety and migraines.
22 peanut anaphylactic patients took part in this small scale trial of oral immunotherapy. All patients were desensitised after 8 months of treatment. This remained in 68% of these patients after two years, suggesting oral immunotherapy is able to improve threshold for tolerance in some anaphylactic individuals.
100 children with diagnosed wheat allergy were fed well cooked wheat spaghetti daily for 17 weeks, at increased doses over the period. Just over half the children with wheat allergies could use wheat in their daily diet over one year later. However 94% experienced adverse reactions to the oral immunotherapy.
This study assessed soybean seeds that had been subjected to different thermal processing treatments to see if there were any differences in their capacity to bind to IgE and therefore induce allergic reactions. It was found that ‘treatment that combined heat and pressure produced a fragmentation of proteins in both soluble and insoluble fractions that went along with a decreased capacity to bind IgE’. Cooking methods may play an important role in increasing the ability to soybean and potentially other allergens.
Some interesting new research that suggests the potential of microorganisms to be used as an anti-food allergy medication.
Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case–control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children.
4th February 2018
Very interesting studying finding that faecal calprotectin levels (that indicate gut inflammation) are higher in individuals with autistic spectrum disorders and their siblings than non-autistic controls. It was also discovered that the level of inflammation was associated with symptom scores on an autism diagnostic interview.
Inflammatory bowel disease is a gut disorder characterised by inflammation of the intestines and changes in gut bacteria. This study explored the effect of a dietary protocol on gut bacteria and intestinal inflammation in this condition. Inflammatory markers decreased, alongside noted alterations in gut bacteria, in individuals who followed the Specific Carbohydrate Diet.
Oral allergy syndrome. Jan 2018
A review of oral allergy syndrome, looking at the current state of the research in the field. The symptoms of mouth and throat itching to specific types of food is relatively common (5-8% of the population) although it is rarely associated with anaphylaxis. The overlap with grass and ragweed allergy in relation to specific fruits and vegetables is discussed.
Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis. Jan 2018
Allergy tests were performed on over 100 patients with eosinophilic esophagitis. Guided by these results, the patients were treated with elimination diet and/or immunotherapy for personal allergens. 78% of patients showed clinical improvement and this was even greater in those who underwent immunotherapy.
For a number of years, evidence has been accumulating to suggest an increase in behavioural and emotional difficulties in children with food allergies. This study reports a potential mechanism for this by identifying that antigen-specific immunoglobulins and mast cell markers in the brain are increased in patients with food allergy. Moreover these brain specific allergy responses were associated with motor and learning deficits, suggesting a plausible mechanism by which allergy can contribute to cognitive symptoms.
Memory and Curcumin in Adults Oct 2017
Adults who received curcumin (derived from turmeric) compared to a placebo, had significant improvements in memory and attention over the 18 month placebo-controlled trial. Decreases in plaques and tangles were noted in brain regions associated with mood and memory. Full article available.
20th January 2018
The outcome of this investigation (spanning around 2/3rds of medical schools in the UK) is that ‘allergy undergraduate teaching is suboptimal and heterogeneous in UK medical schools and there is a real need for standardisation as a means to enhance quality of care’.
Adverse reactions to food: the female dominance - A secondary publication and update. Dec 2017
This interesting review article details research suggesting that, after puberty, females are more likely to suffer from adverse reactions to foods than males. Some possible reasons for this sex difference – such as hormonal changes, exposure to dietary allergens, higher psychological sensitivity and different medications – are discussed. Full text available.
Fish oil in infancy protects against food allergy in Iceland - results from a birth cohort study Jan 2018
This large-scale observational study followed over one thousand Icelandic children from birth to 2 ½ years of age. Those infants who had received regular fish oil supplements were less likely to be diagnosed with food sensitivities.
Inflammatory Bowel Diseases and FODMAPS (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols): An Overview. Jan 2018
A review looking at the efficacy of using the Low FODMAP diet to treat Inflammatory Bowel Disease. Numerous studies have shown that the diet can be effective in reducing abdominal pain and inflammatory markers in both blood and stool samples in individuals with IBD.
6th January 2018
Making All Medications Gluten-free. Dec 2017
Article making the very sensible proposition that all medications should have to be made gluten-free.
An interesting up-to-date review (full text available) of the current state of the research into Coeliac Disease.
Interesting article highlighting the similarities between the symptoms of non-coeliac gluten sensitivity and histamine intolerance, together with thoughts about what this might mean for treatment.
An interesting (full-text) review article exploring the current research into Non coeliac Gluten Sensitivity and overlapping conditions. Issues such as prevalence of the condition and why gluten can cause such adverse reactions are deliberated.
This article considers research into allergic reactions to food additives. It suggests that they may need to be considered particularly in cases of multiple food sensitivity and when sensitivity is greater to commercially prepared rather than homemade food.
The Role of Baked Egg and Milk in the Diets of Allergic Children Feb 2018 (epub ahead of print)
It is suggested that many children with milk and egg allergy are able to tolerate some amount of baked milk or egg products. Being able to consume these may work to reduce sensitivity (in a similar way to immunotherapy). However, if not previously tolerated, any oral challenge should be carried out within a hospital.
In this small scale study, it was found that exclusive early breastfeeding and introduction of fish and eggs into the diet before 10 months of age was associated with a lower risk of developing allergies. Full text available.
15th December 2017
Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. Oct 2017
A study demonstrating that oral immunotherapy for peanut allergy can be both safe and effective. The most common negative side-effects were gastrointestinal. Full text available.
The LEAP study has previously shown that the early consumption of peanut in infants at high risk of peanut allergy reduces the risk of developing peanut allergy. This study found that the benefit is allergen-specific and does not prevent the development of other allergic disease, sensitization to foods other than peanuts. Full article available.
In this study of 59 adolescents with peanut allergy, a high proportion (39%) were also found to be allergic to kiwi.
30th November 2017
This study reports a fourfold increase in allergic gastroentiritis-related hospital admission rates between 1998 and 2014. Most of these were in infants under 1 year. This is similar to the increase that is reported in IgE mediated food allergies. The authors speculate about whether the same causal factors could underpin both.
Home Remodelling and Food Allergy Interact Synergistically to Increase the Risk of Atopic Dermatitis. Sept 2017
In this Korean study, an interaction was found between home remodelling and food allergies: both factors increased the risk of developing moderate-to-severe atopic dermatitis.
This study looked at fifty children with asthma and found a positive correlation between total serum IgE level (level of allergy) and Th2, Th17 cytokines (involved in the immune system). A significant negative correlation was found between the duration of breastfeeding and the cytokines – Children who had been breastfed for longer had lower levels of cytokines. This suggests a possible mechanism by which breastfeeding may reduce risk of allergies in infants. Full article available.
Early life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis. Nov 2017
This review of the current research found evidence that early life exposure to antibiotics appears to be related with an increased risk of allergic symptoms of hay fever, eczema and food allergy later in life.
12th November 2017
Preliminary evidence of differences in the gut bacteria of children with food allergies, compared to those without.
Full-text article reporting that a high proportion of individuals with atopic dermatitis also suffer from respiratory allergies (asthma and rhinitis), with 89% testing positive for at least one airborne.
Association between childhood allergic diseases, educational attainment and occupational status in later life: systematic review protocol. Oct 2017
A British Medical Journal article presenting details of a planned study to review research considering the impact of allergies on school grades and job outcomes. We await the results of this study with great interest.
Effect of pre-harvest and post-harvest conditions on the fruit allergenicity: A review. Oct 2017
Interesting evidence that factors associated with growing conditions and how we harvest, store and prepare fruit may influence its allergenicity.
Cow’s milk allergy that is not IgE-mediated is notoriously difficult to diagnose. Atopy patch testing may be able to detect non-IgE-mediated allergies. However, in this study, patch testing did not prove to be effective for diagnosing this type of milk allergy and is not recommended for clinical practice.
This article considers some of the risk factors (such as genes and family history) predisposing individuals to develop atopic dermatitis. It also considers the many other conditions that are found to be more common in individuals with atopic dermatitis, such as other allergic diseases, ADHD and sleep problems.
Individuals with eosinophilic esophagitis have a higher risk of various atopic diseases such as asthma, rhinitis and dermatitis. This study reports that they are also more likely to suffer from pollen-food allergy syndrome – with one quarter of patients having both conditions.
28th October 2017
The effect of oligofructose-enriched inulin supplementation on gut microbiota, nutritional status and gastrointestinal symptoms in paediatric coeliac disease patients on a gluten-free diet: study protocol for a pilot randomized controlled trial. Aug 2017
An interesting study proposal - to look out for the results of in the future. This proposed study will look at the benefits of administering prebiotics to children with coeliac disease in an attempt to explore whether prebiotics can reduce inflammation, stabilise microbial balance, and reverse nutritional deficiencies. We will await the results of this study, as many individuals with coeliac disease suffer from health and gastrointestinal problems despite following a gluten-free diet.
Effect of childhood coeliac disease on ninth grade school performance: evidence from a population-based study. Aug 2017
This research explored school performance in 445 669 children born in Sweden between 1991 and 1994 of whom 1767 were diagnosed with coeliac disease. A positive association was found between scores at ninth grade and parental education and income. However, Coeliac disease diagnosis during childhood is not associated with poor school performance at ninth grade.
The results of this study will not surprise anyone who shops for gluten-free(GF) food: GF products were 159% more expensive than regular products (£0.44/100 g versus £1.14/100 g). In addition, it was found that GF items were also more likely to be lower in fibre and protein content than regular foods.
This paper highlights the links between atopic dermatitis and other conditions such as sleep disturbance and mental health difficulties. It is suggested that the social, emotional and personal impact of atopic dermatitis should be considered.
There has been much interest in the role that the bacteria living in the gut (microbiota) might play in the development and potential treatment of food allergies. This study identified some interesting differences in the gut bacteria of infants who developed food allergies to those who did not. This warrants further investigation to understand more about the differences and potential causality of the relationship.
This review of recent research suggests that early exposure to both peanuts and eggs may reduce the risk of developing allergy to these foods in high risk infants.
12th October 2017
The onset of coeliac disease in predisposed individuals is thought to require some kind of external trigger. Such triggers may be viruses and intestinal infections such as reoviruses.
Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Aug 2017
This study explored the utility and validity of a non-invasive blood test for diagnosing coeliac disease, looking at plasma intestinal-fatty acid binding protein (I-FABP). Preliminary evidence suggests this may be a useful diagnostic tool for coeliac disease in some children. Full text available.
Patients and parents are often wary and anxious about undergoing food challenges for known allergens. This wide-scale study in the United States, of over 6,000 oral food challenges, resulted in anaphylaxis in just 2% of cases – with 14% experiencing any form of allergic reaction.
Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. Aug 2017
A review of non-IgE mediated cow’s milk protein allergy and consideration of guidelines for primary care. Full text available.
Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. Sept 2017
This study assessed the safety and efficacy of sublingual immunotherapy for birch pollen-related apple allergy. Two different formulations both produced numerous adverse reactions but none which were systemic. The treatments were found to successfully reduce hypersensitivity and deemed clinically effective.
Increasing research has suggested that exposure to food allergens through damaged skin is implicated in the development of food allergies. This research looked at kitchen workers and domestic cooks and found a higher prevalence of food allergy in those with hand eczema. This association was more marked in kitchen workers, suggesting a potential causal mechanism. However, it is impossible to know whether the reported food allergies are a result of exposure to allergens through the skin. Both eczema and food allergies could be the result of other factors but such results warrant further investigation.
30th September 2017
Oral food challenges reduce stress and improve Quality of Life among parents who believe their children have allergies but when those children have not undergone allergy tests. August 2017
The Role of Nutritional Aspects in Food Allergy: Prevention and Management. August 2017
Anti-allergic activity of glycyrrhizic acid (the sweet tasting constituent of liqurice root) on IgE-mediated allergic reaction by regulation of allergy-related immune cells. August 2017
Human Milk and Allergic Diseases: An Unsolved Puzzle. August 2017
Does curcumin impact on allergies? The role of interleukin-10. August 2017
Environmental pollution and allergies. July 2017
17th September 2017
Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews. August 2017
Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study. August 2017
Combining anti-IgE with oral immunotherapy. August 2017
Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins. August 2017
Effects of daily food processing on allergenicity. August 2017
2nd September 2017
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. January 2017
* Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial. August 2017
This study presents some very promising results showing long-term benefits of peanut oral immunotherapy, combined with a probiotic, for many patients. The original research demonstrated that combined probiotic and peanut immunotherapy induced sensitisation in a significant proportion of participants (using a randomised, double-blind, placebo-controlled trial). This follow-up study demonstrates that, 4 years after this intervention treatment ended, many participants were still experiencing positive immune system effects, such that they were able to safely consume peanuts. 67% of the treatment group had continued to eat peanuts, compared to just a single participant (4%) from the control group who did not receive the treatment. Whilst not all participants benefitted from this treatment, the high proportion of responders is very exciting and suggests more research is needed into this combined therapy, which has the potential to make a huge difference to the quality of life of many food allergy sufferers.
This review study outlines that probiotics are often used in an attempt to prevent the development of allergy but that there still a limited amount of evidence to back this up and much more research is required in this area.
This study demonstrates that quality of life was improved for patients with irritable bowel syndrome (IBS) who received an IBS guidebook. This demonstrates the considerable importance of patient education in the effective management of IBS.
The coexistence of psychiatric and gastrointestinal problems in children with restrictive eating in a nationwide Swedish twin study August 2017
This large-scale study, looking at nearly 20,000 children in Sweden, found that those with restrictive eating habits were much more likely to have co-existing psychiatric or gastrointestinal conditions. This suggests that in children who present early with restrictive eating patterns it may be important to consider the possibility of co-occurring disorders.
19th August 2017
Low Food Allergy Prevalence Despite Delayed Introduction of Allergenic Foods - Data from the GUSTO Cohort – Asian populations July 2017
Can Early Omega-3 Fatty Acid Exposure Reduce Risk of Childhood Allergic Disease? July 2017
Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy. July 2017
Parents' and caregivers' experiences and behaviours when eating out with children with a food hypersensitivity. July 2017
Donkey´s Milk Is Well Accepted and Tolerated by Infants with Cow´s Milk Food Protein-Induced Enterocolitis Syndrome (FPIES): A Preliminary Study July 2017
Celiac disease, non celiac gluten sensitivity and wheat allergy: comparison of 3 different diseases triggered by the same food. June 2017
23rd July 2017
A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: outcomes of a randomised controlled trial. July 2017
Comparison of nutrient intake in adolescents and adults with and without food allergies. July 2017
A History of Cow's Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren.
Nutrition and Allergic Diseases. July 2017
Timing of food introduction and atopy prevention. July 2017
Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review. July 2017
4th July 2017
Food allergy response capabilities of mothers and related factors. June 2017
"Healthcare seems to vary a lot": A focus group study among parents of children with severe allergy. June 2017
Bullying and quality of life in children and adolescents with food allergy. June 2017
Associations of self-reported allergic diseases and musculoskeletal problems in children: A US population-based study. June 2017
Awareness of coeliac disease among chefs and cooks depends on the level and place of training. 2017
24th June 2017
Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing.
An update on the impact of food allergy on anxiety and quality of life. May 2017
Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review. May 2017
Probiotic influences on allergic responses in mice. May 2017
Regulatory T Cells in Allergy and Asthma May 2017
Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases. May 2017
Histamine and Tourette’s syndrome – tics disappear in mice treated with histamine June 2017
8th June 2017
Elimination diet and the development of multiple tree-nut allergies. May 2017
Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy. April 2017
The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. April 2017
Disappearance of severe oral allergy syndrome following omalizumab treatment. May 2017
In-flight allergic emergencies. May 2017
Coexistence of celiac disease & type 1 diabetes mellitus in children. Jan 2017
Retrospective evaluation of pregnant women with celiac disease. March 2017
Gastric bypass surgery radically improves subjects' gut biomes. May 2017
28th May 2017
Neurological manifestations of atypical celiac disease in childhood. April 2017
Safety of Adding Oats to a Gluten-free Diet for Patients with Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. April 2017
Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study May 2017
13th May 2017
Validation of Antibody-based Strategies for Diagnosis of Pediatric Celiac Disease Without Biopsy. April 2017
Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy? April 2017
Coeliac disease: further evidence that biopsy is not always necessary for diagnosis. June 2017 (Epub ahead of publication)
Coeliac Disease and Gastrointestinal Symptom Screening in Adult First-degree Relatives. April 2017
Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity. April 2017
Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. March 2017
Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children April 2017
30th April 2017
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. April 2017
Homeopathy for Allergic Rhinitis: A Systematic Review. Feb 2017
Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models. March 2017
Novel immunotherapy and treatment modality for severe food allergies. March 2017
Growth of Children with Food Allergy March 2017
Impact of school peanut-free policies on epinephrine administration. March 2017
15th April 2017
The evidence base for efficacy of the low FODMAP diet in irritable bowel syndrome: is it ready for prime time as a first-line therapy? March 2017
The clinical value of breath hydrogen testing for FODMAP sensitivity. March 2017
Low FODMAP in 2017: Lessons learned from clinical trials and mechanistic studies. April 2017
The Low FODMAP Diet: Many Question Marks for a Catchy Acronym March 2017
How to institute the low-FODMAP diet. March 2017
Dietary interventions for recurrent abdominal pain in childhood. March 2017
Review of the effects of fermented milk with healthy bacteria on gastrointestinal discomfort in the general adult population. Jan 2017
2nd April 2017
Impact of elimination diets on nutrition and growth in children with multiple food allergies. March 2017
Update on Timing and Source of 'Allergenic' Foods. March 2017
A Limited Survey of Dark Chocolate Bars Obtained in the United States for Undeclared Milk and Peanut Allergens. March 2017
The impact on quality of life on families of children on an elimination diet for Non-immunoglobulin E mediated gastrointestinal food allergies. Feb 2017
Anaphylaxis in Schools: Results of the EPIPEN4SCHOOLS Survey Combined Analysis. March 2017
Next Generation: Personalized Probiotic Skin Care February 2017
Bacterial Spray Promising for Keratosis Pilaris. March 2017
17th March 2017
Coeliac disease in the 21st century: paradigm shifts in the modern age. March 2017
Non-coeliac gluten sensitivity. March 2017
Gluten-induced cognitive impairment ("brain fog") in coeliac disease. March 2017
Calcium in Gluten-Free Life: Health-Related and Nutritional Implications. July 2016
Risk of Cross-Contact for Gluten-Free Pizzas in Shared-Production Restaurants in Relation to Oven Cooking Procedures. Sept 2016
Many children with coeliac disease may also experience oral manifestations of the condition. This article suggests that children with coeliac disease more frequently suffer from poorly formed tooth enamel and mouth ulcers than other children. Detection of these symptoms could be a warning sign for further investigations. Do we need to educate dentists to spot these symptoms and suggest children for follow-up?
5th March 2017
The emotional, social, and financial burden of food allergies on children and their families. March 2017
Probiotics improve quality of life for seasonal allergy (e.g. hay fever) sufferers.
Food Allergy Knowledge and Attitudes of Restaurant Managers and Staff. Sept 2016
Food Protein-Induced Enterocolitis Syndrome. Feb 2017
Safety and feasibility of heated egg yolk challenge for children with egg allergies. Feb 2017
Review suggests that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to infants' diets. Feb 2017
16th February 2017
That Valentine's day kiss.... Not so simple, or so romantic, if you have a food allergy.... Kate Lawrence looks at some of the research around allergic reactions that have been triggered by a kiss. February 2017
5th February 2017
Food-Allergic Adolescents at Risk for Anaphylaxis: A Randomized Controlled Study of Supervised Injection to Improve Comfort with Epinephrine Self-Injection Jan 2017
Yogurt consumption in infancy is inversely associated with atopic dermatitis and food sensitization at 5 years of age: a hospital-based birth cohort study.
Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre. Jan 2017 This study assessed vitamin D levels in children with gastrointestinal food allergy at Great Ormond Street Hospital. It was found that children with non-IgE mediated gastrointestinal food allergy are at risk of vitamin D insufficiency and deficiency. The Full article is available for free.
The Establishment of Cow's Milk Protein Allergy in Infants is Related with a Deficit of Regulatory T cells (Treg) and Vitamin D.
Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. Oct 2016
Irritable bowel syndrome and diet. Jan 2017
Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome (IBS). Oct 2016
19th January 2017
Coeliac disease: a unique model for investigating broken tolerance in autoimmunity. Nov 2016
The progression of coeliac disease: its neurological and psychiatric implications. Dec 2016
Extensively hydrolysed casein formula containing L. rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial. Dec 2016
Efficacy and safety of high-dose rush oral immunotherapy in persistent egg allergic children: A randomized clinical trial. Jan 2017
Further research evidence to suggest that oral immunotherapy for egg allergy is both safe and effective. Low-dose OIT induced sustained unresponsiveness to 1/32 and 1/2 of a whole egg, with no severe symptoms. To improve food allergies, continuous intake of small amounts of these foods may be as effective as the consumption of larger quantities.
8th January 2017
Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy. December 2016
An Examination of the Food Allergy Quality of Life Questionnaire Performance in a Countrywide American Sample of Children: Cross-Cultural Differences in Age and Impact in the United States and Europe. December 2016
Consultation with registered dietitian to prevent accidental reactions to food: insight from an egg allergy influenza vaccination cohort. December 2016
Peanut allergy as a family project: social relations and transitions in adolescence. December 2016
Allergic sensitization in kidney transplanted patients - Is it a result of immunosuppressive agents or sensitization of the living donor? December 2016
Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis. December 2016
11th December 2016
Food Allergy in Atopic Dermatitis.
Randomized Controlled Trial of Oral Immunotherapy for Egg Allergy.
Low FODMAP Diet for treating IBS
Lupin and Other Potentially Cross-Reactive Allergens in Peanut Allergy.
Introducing Allergenic Food into Infants' Diets: Systematic Review.
27th November 2016
Gut microbes in babies – associated with development of allergies
Special Issue on Coeliac Disease. United European Gastroenterology Journal
Food allergies in the elderly
Pre- and probiotics for allergy prevention: time to revisit recommendations?
Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization.
12th November 2016
A pill to treat coeliac disease? Not quite – here’s what the science says
Managing the pediatric patient with celiac disease: a multidisciplinary approach
Great review article about the influence of probiotics and prebiotics on brain function, emotion and thinking. Probiotics (beneficial gut-bacteria) and prebiotics (which feed the bacteria) are being increasingly investigated regarding their role in allergy prevention and treatment. It is interesting to note that there is also increasing evidence that these friendly bacteria are involved in brain function and mental health. This article reviews both animal and human research which suggests that manipulating gut bacteria, to increase the number and activity of beneficial bacteria, improves cognitive function and mood. Pro-biotics appear to achieve similar results to some anti-depressants for example, in terms of improving mood and reducing anxiety. The potential for using such supplements for treating mental health conditions is immense.
Skin patch could help kids with peanut allergies
Detection of major food allergens in amniotic fluid: initial allergenic encounter during pregnancy. November 2016
The ingestion of cow’s milk formula in the first 3 months of life prevents the development of cow’s milk allergy
29th October 2016
Is there a relationship between gluten sensitivity and postural tachycardia syndrome? (Abnormal increase in heart rate that occurs after sitting up or standing causing dizziness or fainting) Dec 2016 (Epub ahead of print)
IgE cross-reactivity of peanut with walnut and soybean in children with food allergy. October 2016
Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties. October 2016
Does concurrent breastfeeding alongside the introduction of solid food prevent the development of food allergy? October 2016
Omalizumab facilitates rapid oral desensitization for peanut allergy. September 2016
15th October 2016Assessment of IgE-mediated food allergies in children with atopic dermatitis. September 2016
More than one quarter of children with atopic dermatitis were found to have food allergies. The researchers suggest that all children with atopic dermatitis should be screened for food allergy.
Australian researchers are a step closer to a peanut allergy vaccine. September 2016
Giving antibiotics to children increases allergy risk September 2016
Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis. September 2016
Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. September 2016
Human milk oligosaccharides and development of cow's milk allergy in infants.
Some encouraging results regarding desensitisation to egg and milk allergens using oral immunotherapy.
30th September 2016
Active treatment for food allergy.
Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases.
Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment.
Lower levels of omega-3 fatty acids are found in blood samples of individuals with ADHD compared to individuals of the same age without ADHD. These authors review 25 research studies that have assessed whether giving omega-3 supplements to children with ADHD produces any improvement in symptoms. The studies produce differing results, but overall there seems to be evidence that omega-3 supplements can help alleviate the severity of the symptoms in ADHD, and may be especially helpful in patients with mild forms of ADHD. Given that the supplement is very safe, with few reported side-effects, it may well be worth a try before stimulant medications, which are associated with severe side-effects for some individuals. Full article available here for free…
Gluten contamination in gluten-free bakery products: a risk for coeliac disease patients.
Celiac Disease and Epilepsy: The Effect of Gluten-Free Diet on Seizure Control.
Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics.
This reports a case-study of a single patient with autism and coeliac disease. Treatment with probiotics reduced severity of abdominal symptoms but, interestingly, also led to an improvement in autistic symptomatology. Full article available here for free…
Earlier reports collated by John Scott.
13th April 2016
Patients with celiac disease may have normal weight or may even be overweight. Only one third of patients with CD in this study had a low BMI. February 2016
The coexistence of coeliac disease and ulcerative colitis is extremely rare in childhood. However, ulcerative colitis should be considered in coeliac children on restrictive gluten-free diet with persistent diarrhoea or bleeding from lower gastrointestinal tract. January 2016
More than 50% of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry. April 2016
Wheat allergy: diagnosis and management - possibly with immunotherapy. January 2016
Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. February 2016
Delivery by Caesarean section predisposes to development of food allergy but not atopic dermatitis in early childhood. February 2016
New website, AllergenOnline.org provides access to a peer reviewed allergen list and sequence searchable database intended for the identification of proteins that may present a potential risk of allergenic cross-reactivity.
Both organic milk and meat contain around 50% more beneficial omega-3 fatty acids than conventionally produced products. February 2015
Oral immunotherapy for peanut allergy induces eosinophilic esophagitis: three pediatric case reports. February 2016
Dying Epithelial Cells Regulate the Immune System: Finding Could Aid Treatment of Inflammatory and Allergic Diseases. February 2016
31st March 2016
Identification and molecular characterization of oat peptides implicated on coeliac immune response. February 2016
A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands. January 2016
Different Gene Expression Signatures in Children and Adults with Celiac Disease. February 2016
The opioid effects of gluten exorphins: asymptomatic celiac disease. November 2015
Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten Challenge. February 2016
Current evidence summarised which shows that human mast cells play a central role at the GI barrier, both in health and disease. February 2016
Could the food we eat affect our genes? Study in yeast suggests this may be the case. February 2016
Recent studies suggest that early rather than late introduction of allergenic foods reduces the risk of food allergy. The preferred timing of food introduction might be sooner than the current recommendation, and might apply not only to high-risk infants. April 2016
American adults with allergies, especially to nuts and seasonal pollen, have low diversity, reduced Clostridiales, and increased Bacteroidales in their gut microbiota. November 2015
Limited evidence to support maternal n-3 LCPUFA supplementation during pregnancy and/or lactation for reducing allergic disease in children. July 2015
17th March 2016
Long-term follow-up of oral immunotherapy for multiple food allergies suggest that tolerance can be maintained when subjects continue to consume the allergens regularly. March 2016
Optimal needle length for an Epinephrine auto-injectors (EAI) for infants weighing 7.5 to 15kg should be shorter than the needle length in current, commercially available pediatric EAI, in order to avoid striking the bone and possible intraosseous injections. March 2016
Meta review suggests that there is no consistent advantage to using a hypoallergenic formula over a standard formula for preventing the development of cow's milk allergy in high risk infants. March 2016
Shellfish and house dust mite allergies: is the Link Tropomyosin? March 2016
Peanut exposure in public settings is most likely to occur by contact with surfaces harboring allergens rather than by inhalation, even in peanut-rich environments. March 2016
Coconut oil – a nutty idea? A report in the Nutrition Bulletin suggesting that coconut oil's high saturated fat content may still make it a risk for cardiovascular disease although this link is now being re-exmined. Also pointing out that there is, as yet, very little human research into the benefits or otherwise of coconut oil consumption. February 2016
Three novel candidate probiotic strains with prophylactic properties in a murine model of Cow's Milk Allergy. January 2016
Changes in gut microbiota may lead to activation of an inflammatory pathway and thereby to coeliac disease. January 2016
Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011-2012. January 2016
Dietary management of peanut and tree nut allergy: should peanut allergic patients always avoid products with 'may contain nuts' warnings? April 2015
Allergic reactions to pine nuts: a review. 2015
20th February 2016
Association of ADHD and Celiac Disease: no conclusive evidence. January 2016
From coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free? March 2016
Apparently asymptomatic sufferers of coeliac diseases very often develop diseases that can be related with gluten intake. Gluten can be degraded into several morphine-like substances – gluten exorphins. These compounds have proven opioid effects and could mask the deleterious effects of gluten protein on gastrointestinal lining and function. November 2015
Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016
Just under half the infants with confirmed food hypersensitivity, studied as part of Euro Prevall birth cohort study, had no demonstrable IgE. January 2016
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. January 2016
Most egg allergic children can tolerate high protein baked egg products. January 2016
Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. January 2016
Oral immunotherapy for peanut allergy induces early, distinct changes in immune T-cell populations that may help researchers determine which people will respond well to the therapy. January 2016
A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges. June 2015
How normal diet establishes immune tolerance conditions in the small intestine. January 2016
Except when fermentation or hydrolysis are used, food processing does not alter the allergenic properties of food proteins so as to reduce their allergenic potential. June 2015
A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity. December 2015
7th February 2016
Celiac Disease and Drug-Based Therapies: Inquiry into Patients Demands. January 2016
Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification. January 2016
Rare association of celiac disease with myasthenia gravis in a patient with other immune disorders: A case report. January 2016
Contemporary celiac disease diagnosis: is a biopsy avoidable? March 2016
Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity. January 2016
Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy. October 2015
New approach for food allergy management using low-dose oral food challenges and low-dose oral immunotherapies. January 2016
Limiting infants to almond milk can result in scurvy. January 2016
23rd January 2016
Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016
Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children. December 2015
Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. June 2015
Malrotation of midgut in adults, an unsuspected and neglected condition-An analysis of 64 consensus confirmed cases. Abnormal duodenojejunal junction (DJJ) was a consensus finding in 64 cases referred for RAP (recurrent abdominal pain). Most were in their fourth decade of life, and 12 were over 60. Besides RAP, intolerance to food was the next common symptom. November 2015
Effects of Egg White Consumption on Immune Modulation in a Mouse Model of Trimellitic Anhydride-induced Allergy. This study shows that the consumption of egg white by allergic mice did not increase their allergic response. June 2015
Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial: a critical appraisal. November 2015
High maternal consumption of milk products during pregnancy may protect children from developing CMA (cow's milk allergy), especially in offspring of non-allergic mothers. January 2016
Cord Blood Cells Foretell Food Allergy. January 2016
Worrying number of parents do not know how to give an emergency epinephrone or adrenaline shot. January 2016
The Role of Helminth Infection and Environment in the Development of Allergy: A Prospective Study of Newly-Arrived Ethiopian Immigrants in Israel. The increased allergy among immigrants one year after immigration may reflect the combined influence of the decreased helminth load as well asnovel environmental factors. January 2016
Childbirth and consequent atopic disease: emerging evidence on epigenetic effects based on the hygiene and EPIIC (Epigenetic Impact of Childbirth) hypotheses. January 2016
9th January 2016
The ever-increasing number of coeliac disease-related liver injuries suggest the wisdom of testing for CD in cryptogenic hepatobiliary conditions where the relationship with CD has not yet been fully investigated. November 2015
Risk of venous thromboembolism in patients with celiac disease: A systematic review and meta-analysis shows a signifcantly increased risk. December 2015
The high prevalence of coeliac disease in children with Type 1 diabetes emphasizes the need for routine screening programs to be in place for these high-risk populations. December 2015
High prevalence of celiac disease among first-degree relatives of Indian celiac disease patients. November 2015
It may be possible to tailor gluten for the production of hypoallergenic flours while still taking advantage of its unique viscoelastic properties. December 2015
The overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: a clinical dilemma. December 2015
Researchers find link between processed foods and autoimmune diseases. December 2015
Recent studies suggest anti-histamine therapy might efficiently combat inflammation in atopic dermatitis. December 2015
Timing of routine infant vaccinations may be relevant to the risk of food allergy and eczema at one year of age. December 2015
Because of the growing restrictions on the use of bisphenol A in food contact materials, several bisphenol analogs are now being used instead. A way of identifying them. November 2015
The alternatives to BPA that are being used in the manufacture of “BPA-free” products are not necessarily safer. December 2015
Emotional and behavioral problems, particularly symptoms of depression, anxiety, and ADHD are common among adolescents with food allergy. December 2015
Challenge with instant skim milk powder could be a safe, convenient and easily standardizable alternative to home baked food for heated milk challenge. December 2015
Breast feeding, although conferring other health benefits, does not appear to protect against allergic disease. December 2015
Prompt treatment with cow's milk free formula leads to clinical remission of severe FPIES in infants. December 2015
Beneficial effects of the use of camel milk in the management of children with autism:
19th December 2015
Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. November 2015
Organically grown tomatoes appear to offer little advantage over conventionally cultivated plants in terms of reduced allergenic potential. November 2015
Fish allergic patients have been generally advised for strict universal avoidance of fish. However, testing with various fish species or preparations might identify one or more forms that can be tolerated. February 2015
Cross-reactivity exists between chickpea and pea/lentil/soybean/hazelnut. Chickpea allergy is associated with lentil and/or pea allergy, but evidently may not present independently. This suggest that chickpea allergy is merely an expression of cross-reactivity, caused by pea and/or lentil as the "primary" allergen. December 2014
Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences. November 2015
Food Allergen Guidelines for US Producers (Prevention and Control, and Declaration through Labelling) November 2015
Current overview of allergens of plant pathogenesis related protein families. February 2014
In patients with symptoms triggered by histamine-rich food, measuring the serum diamine oxidase activity can help identify subjects who can benefit from a histamine limitation diet and/or diamine oxidase supplementation. November 2015
Season of birth shapes neonatal immune function. October 2015
Celiac disease manifest as a neurologic condition in 10% of all CD patients. The most common are cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression and cognitive deficiencies. A review. November 2015
The anti-inflammatory and anti-oxidant properties of almond milk suggest that almond milk might be considered as a potential alternative in cows milk protein allergy treatment. June 2015
Atopic disease is associated with chronic inflammation, food allergen avoidance, and use of systemic immunosuppressant medications. All these factors have been shown to be associated with anemia. November 2015
US allergics – beware of 'natural flavours' – they could include 'your' allergen. December 2015
Allergy awareness poor among chefs in the US. December 2015
In 2010 four selected chemicals (dioxin, aflatoxin, peanut allergen and cyanide in cassava) were estimated to be collectively associated with 339,000 illnesses, 20,000 deaths, and 1,012,000 DALYs - findings of a WHO Taskforce. December 2015
Children with allergic disease, particularly asthma and hay fever, have about twice the rate of high blood pressure and high cholesterol, setting them on a course for heart disease at a surprisingly early age. Comment here. December 2015
A study of more than 2,700 mothers of children with autism shows that about one in 10 mothers have antibodies in their bloodstream that react with proteins in the brain of their babies possiby causing autism.
Allergen Immunotherapy: History and Future Developments. October 2015
Novel Delivery Routes for Allergy Immunotherapy: Intralymphatic, Epicutaneous, and Intradermal. 2015
Advances in the Treatment of Food Allergy: Sublingual and Epicutaneous Immunotherapy. 2015
Oral Immunotherapy for Food Allergy - with reference to cow's milk, hen's egg, and peanut. 2015
Evaluating the impact of infant feeding guidelines on CMA prescribing in UK primary care. This study shows promising results for prospective research on a national scale, including socio-economical impact and cost-effectiveness. November 2015
5th December 2015
Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder. December 2015
Studies in experimental models are contributing to understand the role of intestinal bacteria and its interactions with a predisposed genotype in promoting CD. Advances in this area could aid in the development of microbiome-informed intervention strategies. November 2015
Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing. November 2015
Early feeding practices seem to have no impact on the risk of developing CD during childhood. November 2015
A review of complexity of the cereals from which gluten is derived, the special properties of gluten which make it so widely used in the food industry, the basis for its toxicity in CD patients and the potential for the development of safe gluten and alternatives to the gluten-free diet. November 2015
A review of selection methods for immunomodulatory probiotic strains and the mechanism of action of probiotics in immune modulation. 2015
In a large cohort of infants with atopic dermatitis at risk for development of food allergy, food-antigen-specific immunoglobulin E (sIgE) levels were not clinically useful for predicting food allergy development. December 2015
Exposure to Giardia infection was associated with perceived food intolerance 3 years after giardiasis. Perceived intolerance to high FODMAP foods and low FODMAP foods were both statistically significantly associated with exposure to Giardia infection. November 2015
This review summarizes the evidence on EoE pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. November 2015
By acting on intestinal and systemic immune functions, a cocoa-enriched diet in rats exhibited a protective effect against food allergy and partially against anaphylaxis, making this a food of high interest to the fields of health and immunonutrition. October 2015
Consuming a cow's milk exclusion diet during infancy has persistent and long-term effects on eating habits and food preferences. November 2015
Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species. October 2015
Awareness of sesame allergies grows amid push for more accurate food labeling Novmeber 2015
Management of simple food allergy by community paediatricians in Australia appears feasible and acceptable to paediatricians and families alike. November 2015
T Cell Epitope Immunotherapy Ameliorates Allergic Responses in a Murine Model of Shrimp Allergy. November 2015
Consumption of certain food and natural materials such as fenugreek, skullcap, chitin/chitosan, and cheonggukjang as anti-allergics have merits such as safety (no adverse side effects), multiple suppressive effects and ease of consumption when required. 2015
It may be important to consider the diversity of food allergy in order to fight against food allergy. 2015
21st November 2015
Dietary vegetable oils rich in n-6 PUFA may enhance the susceptibility to develop or sustain food allergy. August 2015
The controversial role of food allergy in infantile colic: evidence and clinical management. March 2015
Probiotics may improve effectiveness of peanut oral immunotherapy. March 2015
Food the most common trigger of anaphylaxis in paediatric population but epinephrine underused and children may have several episodes before being assessed by an allergist. November 2015
There is insufficient evidence for using Oral or sublingual immunotherapy to treat allergy to fruit, specifically related to peach and apple. November 2015
Allergic mechanisms of Eosinophilic oesophagitis. October 2015
Eosinophilic Esophagitis: Another Atopy-Related Alopecia Areata Trigger? November 2015
Correlation of skin barrier impairment in atopic dermatitis with aeroallergen sensitization. November 2015
Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance. November 2015
Feeding at-risk infants gluten increases risk of developing celiac disease. November 2015
Role of oats in celiac disease: it is essential to thoroughly study the variety of oats used in a food ingredient before including it in a gluten-free diet. November 2015
Age-related differences in celiac disease: Specific characteristics of adult presentation. Novmeber 2015
Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. November 2015
In-house test kits help motivate parents to reduce allergens in their homes. November 2015
7th November 2015
Provision of mental health care services, not just screenings, critically important for children with food allergies. October 2015
Recent accumulated evidence suggests that exposure to allergens early in life may promote immune tolerance and contribute to prevent infant food sensitization. May 2014
Skin testing with raw egg does not predict tolerance to baked egg in egg-allergic children. November 2014
Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. August 2015
The Prevalence of Tree Nut Allergy: A Systematic Review. September 2015
Managing semen allergy. October 2015
Managing allergic disease in the elderly. November 2015
Life long gluten-free diet reduces the risk of metabolic osteopathy and joint and muscle problems and the need for analgesic drus. 2015
High levels of zonulin linked to NCGS and IBS. October 2015
The advent of next-generation assays for diagnosis may result in more sensitive screening and ultimately the possible replacement of the intestinal biopsy as the gold standard for celiac disease diagnosis. 2015
There is currently no evidence to support that early introduction of gluten to the infant diet increases the risk of CD; however, late introduction of gluten may be associated with increased risk of CD. October 2015
The Spectrum of Differences between Childhood and Adulthood Celiac Disease. October 2015
Reptiles often chosen as pets when children allergic to dogs or cats but reptiles' food can also cause lasting allergic reactions. October 2015
Significant clinical differences found between children with monosensitization and those with polysensitization to common food allergens. September 2015
Egg allergy less common than supposed and 50% of allergic children likely to gain tolerance within 1 year of diagnosis. October 2015
High prevalence of lipid transfer protein sensitization in apple allergic patients with systemic symptoms. September 2014
Oral immunotherapy for cow's milk allergy still effective after seven years. October 2015
New research suggests that in allergy the immune system mistakes the proteins in environmental allergens (such as foods or pollen) for those in parastic worms which it is programmed to attack. Reseach here; comment here. October 2015
Sublingual immunotherapy in children not only as a therapy but as a preventative measure for food and respiratory allergy. October 2015
24th October 2015
Researchers find that polyamines, moving through a potassium channel, can transmit electrcial signals into the cell thus allowing us to 'sense' and react to electric fields. October 2015
Coeliac Disease – Recognition, Assessment and Management
Can genetic background alone explain the association between coeliac disease and autoimmune diseases or should gluten-related factors be considered? October 2015
Second hand tobacco smoke exposure in infancy appears to increase the risk of sensitization to food allergens as well as eczema up to age 16 years. October 2015
Allergenicity of fish is considered to correlate with the content of parvalbumin and large-sized migratory fish, such as salmon, swordfish and tuna, were commonly very low in both parvalbumin content and IgE reactivity. August 2015
Review of the human gastrointestinal microbiome, focusing on the theory and evidence for its role in the development of IgE-mediated food allergy and other allergic diseases. September 2015
School Food Allergy and Anaphylaxis Management for the Pediatrician—educating the family to partner with their schools and encouraging the school to provide reasonable and effective accommodations, as per state or federal guidelines. October 2015
Allergen component-resolved diagnostic testing (CRD) is a new methodology in clinical food allergy diagnosis, improving the ability to identify specific clinical phenotypes and identifying of specific molecules causing sensitization or allergy. June 2015
How oral food challenges may be designed to assess specific characteristics of the food allergic response. August 2015
Management of Eosinophilic Esophagitis in Adults. October 2015
New-onset food allergy recognised as one of the complications after liver transplantation, especially in pediatric patients. October 2015
Primary immune deficiencies (PIDs) are an uncommon heterogeneous group of diseases that result from fundamental defects in the proteins and cells that enable specific immune responses and can be masked by common allergic reactions. But immune suppression with systemic corticosteroids can be life threatening. September 2015
Primary prevention of allergy: will it soon become a reality? Three interventions discussed. October 2015
The combined presence of schizophrenia and atopic diseases is associated with an increased risk of ischemic stroke in later life. October 2015
10th October 2015
Wheat-Dependent Exercise-Induced Anaphylaxis. September 2015
Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. September 2015
Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources. June 2015
Data indicate that many adult Australians are consciously avoiding consumption of wheat foods, predominantly without any formal diagnosis. Reported symptoms suggest a physiological but not allergenic basis to this behaviour. February 2015
Accurate food adverse sensitivity documentation in electronic health records (EHRs) is crucial to patient safety. This study examined, encoded, and grouped foods that caused any adverse sensitivity in a large allergy repository using natural language processing and standard terminologies. September 2015
Hydrolyzed whey protein prevents the development of cow's milk allergy in sensitized mice. September 2015
Peanut avoidance and peanut allergy diagnosis in siblings of peanut allergic children. January 2015
Although peanut allergy is among the most common food allergies, no study has previously comprehensively described the epidemiology of the condition among the general pediatric population. Jan-February 2015
Patch testing for food allergy: the data, in particular the sensitivity, specificity, and predictive values, vary widely from 0 to 100%, depending on the study so food APT use in isolation is not recommended at this time. Decemebr 2014
Alioidea allergic reactions (to onions and garlic) overview. In the last ten years, the world production of onions and garlic has increased of at least 25% and their growing use is producing more and more specific and sometimes serious medical conditions. 2014
30 – 75% of those with hay fever may have oral allergy syndrome caused by raw fuits and vegetables, but symptoms can be avoided with cooking. September 2015
26th September 2015
Central America in Transition: From Maize to Wheat. Challenges and Opportunities 2015
Alexithymia (the sub-clinical inability to identify and describe emotions in the self resulting in poor emotional awareness, social attachment, and interpersonal relating) higher in food-allergic versus healthy children and young adults. September 2015
FODMAPS diets hold great promise in treating IBS patients in East and Southeast Asia. This review highlights how the diet is implemented, its efficacy, and troublesome ingredients frequently used in Asian dishes. September 2015
Consensus Communication on Early Peanut Introduction and Prevention of Peanut Allergy in High-Risk Infants. September 2015
Epidemiology of anaphylaxis. Could Vitamin D exposure be relevant? September 2015
Food-allergic schoolchildren have a probability of being bullied approximately 2 times higher than healthy peers, in an Italian study. September 2015
Instance of FPIES to fish. September 2015
Turmeric, including various components, may be useful to ameliorate Th2-mediated allergic disorders such as food allergy, atopic dermatitis, and asthma. April 2005
Carrageenan, which causes both raised blood sugar levels and inflammation in animals, is found in sufficient quantities in most western diets to cause similar results in humans. September 2015
Recent studies on correlations between food allergies and intestinal barrier functions, and intestinal barrier function injury summarized to provide reference for laboratory researches and clinical treatment. April 2015
Cow's milk allergy and neonatal short bowel syndrome: comorbidity or true association? September 2013
In a small, preliminary study, infants in households with furry pets were found to share some of the animals’ gut bacteria - possibly explaining why early animal exposure may protect against some allergies. September 2015
Swiss researchers suggest that it might be possible to control allergic reactions by creating T-regulatory (Treg) in the laboratory which could be injectd into the allergy sufferer. Comment here; original research here. September 2015
11th September 2015
Validation of a set of clinical and endoscopic features to predict EoE with a high degree of accuracy and allow identification of those at very low risk of disease. September 2015
Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy. August 2015
Food sensitisation prevalence is highest in infancy and declines after 12 months of age. Food sensitisation at 12 months can predict children at greater risk of adolescent sensitisation and probable food allergy at 12 and 18 years. August 2015
The OIT protocol was safe and effective in inducing egg desensitization. April 2015
A Web site-based reporting system for monitoring home treatment during oral immunotherapy for food allergy. May 2015
BDA Policy statement on gluten-free food on prescription. September 2015
Sodium Cromoglycate prevents exacerbation of IgE-mediated food-allergic reaction induced by Aspirin in a rat model of egg allergy. August 2015
Guidance on the early introduction of peanut to at risk infants based on the results of the LEAP study. September 2015
Researchers successfully establish a causal relationship between exposure to so-called farm dust and protection against asthma and allergies. September 2015
28th August 2015
US Government study finds that 65% of breast milks sampled contained artifical sweeteners. August 2015
From genetics to treatment of eosinophilic esophagitis. October 2015
Cow's milk allergy was observed frequently in children with resistant to pharmacologic treatment of GERD. Combined skin prick and specific IgE tests, atopy patch test and oral food challenge is essential for avoidance of unnecessary elimination diet. August 2015
Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model. June 2015
Traces of ovalbumin and casein detected in white and red wines by quantitative western blotting. August 2015
An insight in to egg hypersensitivity. August 2015
Hypersensitivity to Tomato in Peach-Allergic Patients: rPrup 3 and rPrup 1 Are Predictive of Symptom Severity. 2015
Allergy Therapeutics use a novel proteomic approach to understand the molecular fingerprint underpinning the causative agents of leading causes of allergy. August 2015
Carboxymethylcellulose and polysorbate-80- induced gut microbiota alteration and gut barrier dysfunction in mice, resulting in weight gain, low-grade inflammation, and metabolic disorders. August 2015
Recent studies on correlations between food allergies and intestinal barrier functions. April 2015
FPIES caused by fish and/shellfish in Italy. August 2015
15th August 2015
Does a low FODMAP diet help IBS? August 2015
Exchanging melamine for stainless steel food containers could dramatically reduce the amount of the potentially harmful melamine ingested. August 2015
Systematic review of tree nut allergy suggests that Brazil nut, almond and walnut allergy are most preavanlent in the UK, hazelnut in Europe and walnut and cashew in the US. September 2015
Three month course of oral egg immunotherapy appears to achieve tolerance in egg allergic children. August 2015
The majority of food allergic children who passed an oral food challenge subsequently ate target food regularly and their family's quality of life improved. Adverse reactions were rare and never serious. August 2015
Histamine, histamine intoxication and intolerance. August 2015
Seafood Allergy, Toxicity, and Intolerance: A Review. August 2015
Even if severe allergic reaction is in doubt, epinephrine should be used. August 2015
There is a substantial disagreement between SPT and sIgE for diagnosing allergic sensitization in young children, which increases with age for food sensitization. November 2014
Ara h 2- and Cor a 14-specific IgE are useful to estimate the probability for a positive challenge outcome in the diagnostic work-up of peanut or hazelnut allergy making some food challenges superfluous. November 2014
IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome. November 2014
New developments in allergen immunotherapy. August 2015
Eating oily fish may help kids avoid nasal allergies. August 2015
Detecting hidden ingredients in dietary supplements and medications. August 2015
31st July 2015
Significant relationship observed between peach and symptoms of tomato allergy. IgE positivity for rPru p3 seems to be a surrogate biochemical marker for severe tomato allergy, whereas the presence of anti-rPru p 1 IgE may be an indicator of mild tomato allergy. 2015
Barnacle hypersensitivity. March 2002
Because pine nut is commonly consumed in our environment, the prevalence of allergic reactions is probably considerable and these reactions take place at an early age. Common antigenic proteins are also shared between pine nut and peanuts. March 2002
The chances of having a food allergy are significantly higher if you were born in the autumn or winter while there is a strong negative correlation between the amount of solar radiation the infant is subject to immediately after birth and allergen sensitisation. July 2015
Recognition pattern of kiwi seed storage proteins in kiwifruit allergic children. July 2015
Study identifies a risk of dun pea (a relation of the green pea recently introduced into food manufacture) allergy in legume-allergic patients and in a subset of peanut-allergic patients. NB Legume allergy is the fifth food allergy in Europe. July 2015
Hospitalisation rate for potentially fatal allergic reactions has almost tripled in Australia over the past 13 year. July 2015
Biotin and carnitine deficiency due to hypoallergenic formula nutrition in infants with milk allergy. April 2014
Increased intake of vegetable oil rich in n-6 PUFA enhances allergic symptoms and prevents oral tolerance induction in whey-allergic mice. July 2015
Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort. May 2015
Regular consumption of oily fish and dietary long-chain n-3 PUFAs in childhood might decrease the risk of rhinitis, especially NAR, between the ages of 8 and 16 years. July 2015
Researchers use egg yolks to create supplement that could improve lives of people with celiac disease. July 2015
Baked milk oral immunotherapy effective in only 21% of baked milk allergic patients. July 2015
82% of children who completed the six-month induction phase of oral immunotherapy to milk were able to consume at least 200ml of milk or 6,400mg of milk protein a day and after the two-year maintenance phase, half were consuming milk daily. July 2015
Acutely rice-allergic FPIES child reacted to rice dust on a wrapper which had coverd a rice cake. May 2013
Hazelnut allergy differs between children and adults with respect to frequency of severity, aetiology and relevance of diagnostic parameters. December 2014
Suppression of the immunologic response to peanut during immunotherapy is often transient. December 2014
Oral immunotherapy appeared far more effective than sub-lingual immunotherapy for the treatment of peanut allergy but was also associated with significantly more adverse reactions and early study withdrawal. May 2015
11th July 2015
Prospective survey shows that NCGS has a strong correlation with female gender and adult age but the prevalence of NCGS seems to be only slightly higher than that of celiac disease. May 2014
Patients with asthma are at risk for more severe reactions and are less likely to reach full desensitization during food oral immunotherapy. But most who achieve full desensitization continue to consume milk protein freely after treatment. March 2015
Molecular diagnostics should be used in a targeted manner for an accurate assessment and diagnosis of food allergy, which would also reduce the use of oral challenges, to predict severe reactions and allergy persistence. June 2015
Australian research on how food allergy affects a sufferer's and their family's quality of life. June 2015
Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soap. June 2015
Pending further scientific evidence, the concept of food allergy should be included as a possible cause of IBS, and a dietary approach may have a place in the routine clinical management of IBS. June 2015
An investigation into the relationship between intestinal parasites and different inflammatory bowel disorders. Spring 2015
Wheat allergy diagnostics in children is difficult but the accuracy of wheat allergy diagnosis may be improved by measuring IgE responses to several components of wheat. November 2014
A summary of recent data on the epidemiologic link between sunlight (UVB) and food allergy, and evidence for and against a specific role for vitamin D status. August 2015
The growing world population requires the exploration of new sustainable protein sources to ensure food security. Insects such as mealworm are promising candidates. For safety reasons, a risk assessment, including allergy risks, is needed. Since allergenicity can be influenced by thermal processing, it is highly important to take this into account. June 2015
Induction of regulatory dendritic cells by the probiotic Lactobacillus paracasei L9 prevents allergic sensitization to bovine ?-lactoglobulin in mice. June 2015
Seafood allergy in cooks is mostly characterized by a quick progressive course of disease from the start of the cooking career. The prognosis for continuance in occupation is poor and an emergency kit should be provided for life by the responsible accident insurer. October 2014
An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up. April 2014
Comparison of atopic features between children and adults with eosinophilic esophagitis. October 2014
How to predict biphasic allergic reactions in children. Children are more likely to have a repeat, delayed anaphylactic reaction from the same allergic cause, depending on the severity of the initial reaction. This study looks at the predictors for this phenomenon. June 2015
Respiratory allergy symptoms are set to worsen due to climate change, as air pollution increases the aggressiveness of pollen particles and extends the reproductive season of plants. June 2015
Fecal microbiota transplantation - something more than merely a therapeutic curiosity. An as yet unedited manuscript that has been accepted for publication suggesting that FMT is a potential therapy for a wide range of conditions from ulcerative colitis and type 2 diabetes to autism and Parkinson's disease. July 2015
The wheat proteins and molecules produced during digestion of bread and pasta can survive digestion and potentially pass through the gut lining suggesting that they could have a biological effect. Previous research has been done on pure gluten rather gltuen-containing foods. July 2015
A review of the most recent findings on Non Celiac Gluten Sensitivity and directions to dissipate some of the confusion related to this disorder. May 2015
Researchers at the Univeristy of Oslo suggest that coeliac disease is caused by the T-cells of those genetically predisposed to suffer from coelaic disease mistaking gluten for a virus and initiating an immune reaction. June 2015.
The association between primary IgE sensitization with respiratory symptoms to inhaled allergens and food allergy due to cross-reactive allergen components is important to assess in allergy practice. The use of molecular-based diagnosis improves the understanding of clinically relevant IgE sensitization to cross-reactive allergen components from aeroallergen sources and foods. June 2015
Investigation into the allergic properties of soya beans, the mechanisms of soya bean allergy, prevention and treatment, and effects of plant breeding on the soya bean's allergenicity. June 2015
Allergic acute coronary syndrome (Kounis syndrome). July 2015
Genetic modification of wild Elstar apples resulted in the 'silencing' of their Mal d 1 gene expression and resulting in fewer symptoms in apple allergic patients. July 2015
A very low dose oral food challenge allows some low dose reactive Cow's milk allergic children to change from complete avoidance to partial intake of cow's milk. May 2015
Adrenaline/epinephrine in injector pens can survive freezing. July 2015
The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotics-treated mice model. June 2015
Supplementation of mice with Specific Nondigestible Oligosaccharides during pregnancy or lactation leads to diminished sensitization and allergy in the female offspring. April 2015
Some immunological disturbances caused by repeated exposure to the faeces of two house dust mite species in the valley and desert houses could be ameliorated by curcuma and karkade. May 2015
Immunotherapy tablets for hayfever offer little benefit compared to injectable immunotherapy. July 2015
20th June 2015
High proportions of people with non-celiac wheat sensitivity have autoimmune disease or anti-nuclear Antibodies. May 2015
Oral immunotherapy to egg results in severe eosinophilic esophagogastroenteritis in 9 year old boy. February 2015
Systematic review of 42 research papers did not find widespread or consistent links between mothers' dietary intake and atopic outcomes in their children. December 2014
Extensively hydrolysed rice infant formula good substitute for cow's milk for CMA infants. September 2014
200 scientists warn of the dangers of non-stick cookware and other household products using perfluorinated chemical (PFAS). A report on theDr Mercola site. June 2015
Gluten sensitivity does not appear to be relevant in wheat-dependant-exercise induced anaphylaxis. September 2014
Could rise in the incidence of celiac disease have been caused by the extensive use of the chemical glyphosphate on wheat crops? November 2013
Iodine deficiency a risk for children with severely restricted diets. June 2015
Omega 3 fatty acids may have a role in controlling intestinal allergies. June 2015
Laboratory test suggest that fermentation can significantly reduce the allergenicity of soy products although this now need to be tested inhuman challenge studies. May 2015
Transgenic rice developed with significantly lower levels rice allergens. December 2014
Because egg-allergic children so often 'grow out of' their allergy, they should be challenge tested regularly so that egg can reintroduced when appropriate but challenges are expensive and risky. June 2015
Environmental factors such as smoking, breastfeeding, antibiotic exposure, animal exposure etc not found to be relevant in the development of Eisinophilic Esophagitis. June 2015
Eosinophilic gastroenteritis and colitis increasingly frequent in paediatric patients. June 2015
Food additives more harmful in combination. Long report on the Dr Mercola site on the possibly harmful effects of small amounts of food additives used in combination. June 2015
6th June 2015
Sharing your microbiome with your pooch! Research suggests not only that we share much of our microbial populations with our dogs but that close relations with a dog can have a beneficial effect on our chances of getting an allergy as a child and and improve our health in old age... May 2015
Canadian researchers develop inhibitor peptide (STAT6-IP) which they hope will inhibit the action of the molecule STAT6 which is important in the sensitisation of the immune sytem to allergens. They hope it will direct the immune system away from the allergic response, no matter what the allergen. Research here; comment here. May 2015to be
Leading allergists call for 'a more active approach to management to be adopted, which includes early introduction of potentially allergenic foods, anticipatory testing, active monitoring, desensitisation to food allergens and active risk management'. November 2014
Are children and adolescents with food allergies at increased risk for psychopathology? October 2015
Restricted diets improve symptoms in 4 weeks in non-IgE mediated gastrointestinal food allergies. May 2015
High consumption of peanuts or tree nuts by non-allergic mothers around the time of pregnancy may reduce the risk of nut allergy in the child. April 2015
Human milk oligosaccharides (2' Fucosylactose or 6' Sialyllactose) may have therapeutic potential in allergic disease. May 2015
Even when the children have outgrown their cow's milk allergy, families still have nutritional concerns and should be offered dietary advice to encourage progression to unrestricted diet, prevent eating disorders and impaired growth. May 2015
Do mothers mistake symptoms of undiagnosed cow's milk allergy in infants for a child just 'being difficult'? May 2014
Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap in Japan. August 2014
55% of top selling probiotics in US have detectable gluten traces. May 2015
Perception of lactose intolerance in irritable bowel syndrome patients. October 2014
23rd May 2015
Exposure to traffic-related air pollution in the first year of life increases the risk of developing allergies to food, mould, pets and pests. May 2014
Researchers in Oslo show that allergen-specific T cells are resident in the mucosa outside the pollen season and react strongly to pollen extract, suggesting that these T cells are long-lived resident memory cells. This suggests that anti-inflammatory seasonal hay fever therapy should be initiated prior to season. May 2015
Unlike soyabean proteins, germinated soybean proteins do not appear to provoke serious allergic reactions. May 2015
Type 1 diabetes pathogenesis - Prevention???
The horse immune system can respond to midge bites in a way that prevents - rather than triggers - allergic reactions. Edinburgh researchers believe that this reaction could be adapted to prevent allergies in humans. April 2015
Connection between dry eye and seasonal allergies. April. 2015
Pre-existing inflammation from allergic reactions may set the stage for cancer to spread from one area to another. April 2015
Canadian study finds that children who are allergic to peanuts suffer 37% of reactions in their own homes; 14% in other people's homes, 4.9% in schools where peanus are forbidden and only 3% in schools where they are allowed. April 2015
9th May 2015
Immune reactivity to food coloring. Vojdani 2015
Molecular mimicry as a mechanism for food immune reactivities and autoimmunity. 2015
Oral tolerance and its relationship to food immunoreactivities. Professor Vojdani explains. 2015
Improvement in psychotic symptoms in a boy with complex autoimmune illness after a gluten-free diet. March 2015
Should anyone showing signs and symptoms of the Coeliac Disease be tested and should screening everyone in high-risk groups be considered? April 2014
The genotype of infants at family risk of developing Coeliac Disease, carrying the HLA-DQ2 haplotypes, influences the early gut microbiota composition. This finding suggests that a specific disease-biased host genotype may also select for the first gut colonisers and could contribute to determining disease risk. June 2014
Food protein allergen characterization and quantification, together with the immunoglobulin E epitope mapping, will contribute to the diagnosis/prognosis of food allergy and will lead to a better safety assessment of foods (e.g. novel transgenic foods). April 2015
Sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. September 2014
Professor Aristo Vojdani discusses the history of food testing, analyzes the criticisms of it, reviews the scientific literature, and tours the methodologies. 2015
To improve the accuracy of skin prick tests in diagnosing food sensitivy the quality of the food extracts needs to be improved and both IgE and IgG needs to be measured. 2015
The composition of gut microbiota does not seem to be significantly different between atopic and healthy children, but lower abundance and prevalence of Akkermansia indicate that this bacterium may accompany or play a role in IgE-mediated atopic diseases. April 2015
Dendritic cells which switch on inflammation againt parasitic wroms and allergies controlled by the protein Mbd2. This discovery may enable better targeting of medicine sot combat inflammation. April 2015
25th April 2015
Humans, dogs, cats and horses suffer from similar environmental allergies and immunotherapy seemstot be equally successful in all species. April 2015
Safety and clinical predictors of reacting to extensively heated cow's milk challenge in cow's milk-allergic children. October 2014
Breast milk sold online may contain cow's milk. April 2015
Transfer of peanut IgE sensitisation after combined pancreas-kidney transplant. August 2014
Blood test could predict severity of peanut and seafood allergies. April 2015
Researchers in Madrid and France have developed super sensitive NIR spectroscopy (an analytical technique that detects specific molecules based on their absorption and reflection of light at near infrared wavelengths) which enables them to detect trace levels of peanut over a large area. This would allow manufacturers to test for trace levels of peanut and establish their concentration, thus obviating the need for defensive may contain warnings. They hope to develop the technique for other nuts. Research here. April 2015
Food allergies can be transmitted from blood products to children in rare cases. April 2015
Fears over Roundup herbicide residues prompt private testing. April 2015
Combining a probiotic with peanut oral immunotherapy shows promise. Research here. January 2015
Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. November 2014
Lower bifidobacteria counts in adult patients with celiac disease even on a gluten-free diet. June 2014
11th April 2015
Early, aggressive treatment of patients with infantile atopic dermatitis significantly reduces food allergy incidence by 18 months of age. February 2015
Nasal-spray flu vaccines appear to be safe for children over age two who have egg allergies or asthma. February 2015
Downregulation of angiogenesis factors, VEGF and PDGF, after rapid IgE desensitization and oral immunotherapy in children with food allergy. Jnen 2014
Researchers pinpoint a region in the human genome associated with peanut allergy but warn that there may be other molecular mechanisms that may contribute to whether those who are genetically predisposed to peanut allergies actually develop them. Februry 2015
Peanut 'patch' show promise in the treatment of peanut allergy. February 2015
Infants with a milk protein intolerance should be treated for 2 to 3 months with a hypoallergenic formula, then rechallenged at 6 months. Rechallenging before 12 months could result in cost savings. August 2014
Food allergens affect the intestinal tight junction permeability in inducing intestinal food allergy in rats. December 2014
Allergies can be to cooked as well as, or instead of, to raw legumes. March 2015
'May contan' labelling agreed to be counter-productive for consumers with food allergy. Precautionary allergen labelling (PAL) should reflect actual risk and consumers with food allergy then need to be educated to undertake individualised risk assessments in relation to any PAL present. March 2015
The role of food allergy in infant colic is still unclear. However, where there is a suspicion of food allergy, a short trial with an extensively hydrolyzed cow's proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option. March 2015
Extensive cross reactivity at T cell and antibody level was observed in mouse models among Ara h 1, 2, 3 and 6 (peanut proteins), which may have important implications for the diagnosis and therapy of peanut allergy. March 2015
Molecular diagnosis shows promise in allergy diagnosis. It provides information on allergenic components at the molecular level, allowing better understanding of symptoms and patient adjusted procedures. June 2014
Rush OIT (oral immunthotherapy) appears to be effective and relatively sfe for children with severe peanut allergy. June 2014
Nineteen our of 364 proteins in breast milk different in the milk of allergic and non-allergic mothers with the allergic mother's having higher concentrations of proteins linked to asthma and allergy. March 2015
28th March 2015
Allergenic non-gluten proteins can be lost in boiling process although not in baking suggests that those with non-coeliac wheat allergies might be able to eat boiled pasta but not baked. March 2015
Dogs as probiotics. Researchers at the University of Arizona are recruiting for study of the threapeutic possibilities of the biological connection between humans and dogs that could be shared through saliva, skin, and even faeces. March 2015
Benefits of an integrated approach by food allergists, gastroenterologists, and pathologists in themanagement of Eosinophilic esophagitis. August 2014
Study identifies reduced early diastolic tissue Doppler velocities in infants with cow's milk allergy. August 2014
Three month old infants with low microbiotic richness in their gut and an imblance of gut bacteria have an increased likelihood of developing food sensitisation at 12 months. March 2015
Epidemiologic survey in Japan showed that the hygiene hypothesis and intestinal bacterial flora might influence the development of symptoms and remission of allergic diseases. March 2015
University of Huddersfield uses mass spectrometry analysis to identify the molecular compostion of foods enabling them to identify original ingredients – such as whether gelatine was made from beef or pork or whether an ingredient has been derived from an allergen. March 2015
Danish researchers establish that multiple chemicals in foods (pesticide residues etc) have an additive, 'cocktail' effect greater than that of each individual chenical. Traditionally harm has been assessed only on the harmful effect of each individual chemcial. March 2015
Study suggests that coeliac disease is significantly more common among white Americans than among Hispanics and African Americans although the latter are very likely to adopt a gluten-free diet. March 2015
14th March 2015
Use of antibiotics in pregnancy linked with increased risk of asthma by the age of three. March 2015
Anaphylactic allergic reaction to gelatine in a cold medication in Japan. November 2014
Food allergy and eczema, occurring early in life might be an early warning sign of Primary immunodeficiency diseases. If associated with recurrent infections, clinicians should pursue an immunologic evaluation. January 2015
Concern, in the light of the new peanut allergy prevention research, that parents might now feed whole peanuts to small children. March 2015
A more advanced and much more sensitive test for peanut allergy under development. March 2015
Pitfalls in Food Allergy Diagnosis: Serum IgE Testing. Helpful guidance from Drs David Fleischer and Wesley Burks. January 2015
Although still relatively uncommon, allergy to C sativa/marijuana is being reported with increased frequency. January 2105
Could prenatal and postnatal supplementation of bifidobacteria be effective in primary preventing allergic diseases? July 2014
Could abnormal intestinal microbiota be associated with persistent gastrointestinal symptoms in gluten-free celiac disease patients? Feburary 2015
FDA does not accept the causal link between certian food additives and ADHD. 'More research is needed'. March 2011
Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases. February 2014
Role of cellular immunity in cow's milk allergy: pathogenesis, tolerance induction, and beyond. June 2014
28th February 2015
Early consumption of peanuts can protect against allergy. The results of the LEAP study. February 2015
Researchers from CNRS, INSERM and Université de Limoges have shown that the body restricts the production of IgE in order to prevent allergic reactions. February 2015
Researchers at Imperial College, London, looking at epigenetic changes have discovered 30 new genes which predispose to allergy and asthma. February 2015
Increasing evidence for using a low FODMAP diet in the management of functional gastrointestinal symptoms where food intolerance is suspected December 2014.
DHA-rich tuna oil effectively suppresses allergic symptoms in mice allergic to whey or peanut. October 2014
Role of cellular immunity in cow's milk allergy: pathogenesis, tolerance induction, and beyond. June 2014
Broad bean proteins have the ability to elicit allergic responses due to the presence of clinically relevant allergenic proteins. December 2013