New Research

New research reports are collated for us by Kate Lawrence, a psychologist working at St Mary’s University, Twickenham, where her research focuses on social and emotional development in children and the influence of diet and nutrition on physical and emotional well-being.freefrom_recipes
Both she and her family have numerous anaphylactic food allergies which you can read about here.


15th December 2017

Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. Oct 2017

A study demonstrating that oral immunotherapy for peanut allergy can be both safe and effective. The most common negative side-effects were gastrointestinal. Full text available.


The allergen-specificity of early peanut consumption and the impact on the development of allergic disease in the LEAP Study Cohort. Oct 2017

The LEAP study has previously shown that the early consumption of peanut in infants at high risk of peanut allergy reduces the risk of developing peanut allergy. This study found that the benefit is allergen-specific and does not prevent the development of other allergic disease, sensitization to foods other than peanuts. Full article available.


High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi. Nov 2017

In this study of 59 adolescents with peanut allergy, a high proportion (39%) were also found to be allergic to kiwi.


 

30th November 2017

Allergic gastroenteritgis hospital admission time trends in Australia and New Zealand. Oct 2017

This study reports a fourfold increase in allergic gastroentiritis-related hospital admission rates between 1998 and 2014. Most of these were in infants under 1 year. This is similar to the increase that is reported in IgE mediated food allergies. The authors speculate about whether the same causal factors could underpin both.


Home Remodelling and Food Allergy Interact Synergistically to Increase the Risk of Atopic Dermatitis. Sept 2017

In this Korean study, an interaction was found between home remodelling and food allergies: both factors increased the risk of developing moderate-to-severe atopic dermatitis.


Correlation of cutaneous sensitivity and cytokine response in children with asthma. Nov 2017

This study looked at fifty children with asthma and found a positive correlation between total serum IgE level (level of allergy) and Th2, Th17 cytokines (involved in the immune system). A significant negative correlation was found between the duration of breastfeeding and the cytokines – Children who had been breastfed for longer had lower levels of cytokines. This suggests a possible mechanism by which breastfeeding may reduce risk of allergies in infants. Full article available.


Early life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis. Nov 2017

This review of the current research found evidence that early life exposure to antibiotics appears to be related with an increased risk of allergic symptoms of hay fever, eczema and food allergy later in life.


12th November 2017

A preliminary study of gut dysbiosis in children with food allergy. Oct 2017

Preliminary evidence of differences in the gut bacteria of children with food allergies, compared to those without.


Respiratory comorbidity in South African children with atopic dermatitis. Sept 2017

Full-text article reporting that a high proportion of individuals with atopic dermatitis also suffer from respiratory allergies (asthma and rhinitis), with 89% testing positive for at least one airborne.


Association between childhood allergic diseases, educational attainment and occupational status in later life: systematic review protocol. Oct 2017

A British Medical Journal article presenting details of a planned study to review research considering the impact of allergies on school grades and job outcomes. We await the results of this study with great interest.


Effect of pre-harvest and post-harvest conditions on the fruit allergenicity: A review. Oct 2017

Interesting evidence that factors associated with growing conditions and how we harvest, store and prepare fruit may influence its allergenicity.


Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy. Oct 2017

Cow’s milk allergy that is not IgE-mediated is notoriously difficult to diagnose. Atopy patch testing may be able to detect non-IgE-mediated allergies. However, in this study, patch testing did not prove to be effective for diagnosing this type of milk allergy and is not recommended for clinical practice.


Atopic Dermatitis: Disease Background and Risk Factors. Oct 2017

This article considers some of the risk factors (such as genes and family history) predisposing individuals to develop atopic dermatitis. It also considers the many other conditions that are found to be more common in individuals with atopic dermatitis, such as other allergic diseases, ADHD and sleep problems.


Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis. Oct 2017

Individuals with eosinophilic esophagitis have a higher risk of various atopic diseases such as asthma, rhinitis and dermatitis. This study reports that they are also more likely to suffer from pollen-food allergy syndrome – with one quarter of patients having both conditions.


 

28th October 2017

The effect of oligofructose-enriched inulin supplementation on gut microbiota, nutritional status and gastrointestinal symptoms in paediatric coeliac disease patients on a gluten-free diet: study protocol for a pilot randomized controlled trial. Aug 2017

An interesting study proposal - to look out for the results of in the future. This proposed study will look at the benefits of administering prebiotics to children with coeliac disease in an attempt to explore whether prebiotics can reduce inflammation, stabilise microbial balance, and reverse nutritional deficiencies. We will await the results of this study, as many individuals with coeliac disease suffer from health and gastrointestinal problems despite following a gluten-free diet.


Effect of childhood coeliac disease on ninth grade school performance: evidence from a population-based study. Aug 2017

This research explored school performance in 445 669 children born in Sweden between 1991 and 1994 of whom 1767 were diagnosed with coeliac disease. A positive association was found between scores at ninth grade and parental education and income. However, Coeliac disease diagnosis during childhood is not associated with poor school performance at ninth grade.


An investigation into the nutritional composition and cost of gluten-free versus regular food products in the UK. Aug 2017

The results of this study will not surprise anyone who shops for gluten-free(GF) food: GF products were 159% more expensive than regular products (£0.44/100 g versus £1.14/100 g). In addition, it was found that GF items were also more likely to be lower in fibre and protein content than regular foods.


Diagnosis, comorbidity, and psychosocial impact of atopic dermatitis. Sept 2017

This paper highlights the links between atopic dermatitis and other conditions such as sleep disturbance and mental health difficulties. It is suggested that the social, emotional and personal impact of atopic dermatitis should be considered.


Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood. Aug 2017

There has been much interest in the role that the bacteria living in the gut (microbiota) might play in the development and potential treatment of food allergies. This study identified some interesting differences in the gut bacteria of infants who developed food allergies to those who did not. This warrants further investigation to understand more about the differences and potential causality of the relationship.


Dietary intervention for preventing food allergy in children. Sept 2017

This review of recent research suggests that early exposure to both peanuts and eggs may reduce the risk of developing allergy to these foods in high risk infants.


 

 

12th October 2017

The silent enemy: Celiac disease goes viral. Aug 2017

The onset of coeliac disease in predisposed individuals is thought to require some kind of external trigger. Such triggers may be viruses and intestinal infections such as reoviruses.


Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Aug 2017

This study explored the utility and validity of a non-invasive blood test for diagnosing coeliac disease, looking at plasma intestinal-fatty acid binding protein (I-FABP). Preliminary evidence suggests this may be a useful diagnostic tool for coeliac disease in some children. Full text available.


Multicenter prevalence of anaphylaxis in clinic-based oral food challenges. Oct 2017

Patients and parents are often wary and anxious about undergoing food challenges for known allergens. This wide-scale study in the United States, of over 6,000 oral food challenges, resulted in anaphylaxis in just 2% of cases – with 14% experiencing any form of allergic reaction.


Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. Aug 2017

A review of non-IgE mediated cow’s milk protein allergy and consideration of guidelines for primary care. Full text available.


Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. Sept 2017

This study assessed the safety and efficacy of sublingual immunotherapy for birch pollen-related apple allergy. Two different formulations both produced numerous adverse reactions but none which were systemic. The treatments were found to successfully reduce hypersensitivity and deemed clinically effective.


Hand eczema as a risk factor for food allergy among occupational kitchen workers. Sept 2017

Increasing research has suggested that exposure to food allergens through damaged skin is implicated in the development of food allergies. This research looked at kitchen workers and domestic cooks and found a higher prevalence of food allergy in those with hand eczema. This association was more marked in kitchen workers, suggesting a potential causal mechanism. However, it is impossible to know whether the reported food allergies are a result of exposure to allergens through the skin. Both eczema and food allergies could be the result of other factors but such results warrant further investigation.


30th September 2017

Oral food challenges reduce stress and improve Quality of Life among parents who believe their children have allergies but when those children have not undergone allergy tests. August 2017
Another study looking at quality of life in parents of children with food allergies. Food allergy was unsurprisingly found to put parents under a high degree of stress. In terms of dealing with this, it was found that parents of children who had undergone an oral-food challenge were found to be significantly less stressed.


The Role of Nutritional Aspects in Food Allergy: Prevention and Management. August 2017
This review looks at the changing nature of our understanding of the role of nutrition in the prevention of food allergy: moving from advice of early avoidance of allergens to inclusion of a diverse range of foods early in life. The important roles that essential fatty acids, zinc and vitamin D and pre and pro-biotics may play are also considered.


Anti-allergic activity of glycyrrhizic acid (the sweet tasting constituent of liqurice root) on IgE-mediated allergic reaction by regulation of allergy-related immune cells. August 2017
This study, in mice, suggests that glycyrrhizic acid may serve as an effective anti-allergic agent to prevent and treat IgE-mediated allergic reaction.


Human Milk and Allergic Diseases: An Unsolved Puzzle. August 2017
This review looks at the association between breastfeeding and allergy development. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life.


Does curcumin impact on allergies? The role of interleukin-10. August 2017
Curcumin is a chemical produced by certain plants which is found in abundance in turmeric. Curcumin acts as a natural anti-inflammatory and this may partly be as a result of its ability to induce interleukin-10 (an anti-inflammatory cytokine). This review suggests that the impact curcumin may have on allergies (together with other medical conditions) may be partially mediated by the involvement of interleukin-10.


Environmental pollution and allergies. July 2017
This research paper reviews the interesting state of research considering the role that various environmental pollutants may play in allergies. Pollutants such as air pollutants (e.g. diesel exhaust particles) and chemical substances, have been shown to worsen various allergies (especially asthma) in experimental studies.


 

17th September 2017

Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews. August 2017
This review systematically reviews the current state of the research looking at immunotherapy for asthma. It reports that immunotherapy can produce improvements in asthma symptoms and the need for medication. There is less clear evidence that it has an impact on lung function.


Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study. August 2017
Desensitising children to egg protein (which was very successful) had a significant benefit on the quality of life ratings of their parents/guardians. However, a high proportion (80%) treated with immunotherapy experienced some type of allergic reaction during the study period – which means safety concerns need to be taken very seriously during oral immunotherapy.


Combining anti-IgE with oral immunotherapy. August 2017
This review study considers research where immunotherapy is combined with an anti-IgE (anti-allergy) agent. Immunotherapy can be highly effective in treating allergies but as it involves exposing individuals to the substance to which they are allergic, it can also result in adverse reactions. This review suggests that combining immunotherapy with omalizumab (which is an anti-IgE agent) decreases the frequency and severity of allergic reactions during the process. This, in turn, allows for an increase in the threshold of tolerance to food allergens.


Food Processing: The Influence of the Maillard Reaction on Immunogenicity and Allergenicity of Food Proteins. August 2017
This rather technical, but very interesting, article considers the role that processing food might have on it in terms of its potential to invoke allergic reactions and inflammation. Modified proteins may enhance the immune response, suggesting we need more research in this area to fully understand the effect food processing may have on allergenicity of food proteins.


Effects of daily food processing on allergenicity. August 2017
A review looking at how different cooking methods (boiling, roasting, frying or baking) and different preparation methods (e.g. peeling fruits) might influence the allergenicity of various foods.


2nd September 2017

Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. January 2017
This study used an interesting approach: it identified newly diagnosed cases of neuropsychiatric disorders from private medical insurance claims data in the US. It then looked to see whether the individuals concerned had received a vaccination in the preceding months. Individuals diagnosed with Anorexia Nervosa and Obsessive Compulsive Disorder (in particular) were more likely to have received a vaccination in the 3-12months leading up to the diagnosis, than control participants. This does not imply a causal relationship between vaccinations and these neuropsychiatric disorders but does suggest that further investigation of this could be important to understanding whether vaccinations might play a causal role for a particular sub-group of individuals.


* Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial. August 2017

This study presents some very promising results showing long-term benefits of peanut oral immunotherapy, combined with a probiotic, for many patients. The original research demonstrated that combined probiotic and peanut immunotherapy induced sensitisation in a significant proportion of participants (using a randomised, double-blind, placebo-controlled trial). This follow-up study demonstrates that, 4 years after this intervention treatment ended, many participants were still experiencing positive immune system effects, such that they were able to safely consume peanuts. 67% of the treatment group had continued to eat peanuts, compared to just a single participant (4%) from the control group who did not receive the treatment. Whilst not all participants benefitted from this treatment, the high proportion of responders is very exciting and suggests more research is needed into this combined therapy, which has the potential to make a huge difference to the quality of life of many food allergy sufferers.


Probiotics in Asthma and Allergy Prevention. July 2017

This review study outlines that probiotics are often used in an attempt to prevent the development of allergy but that there still a limited amount of evidence to back this up and much more research is required in this area.


Self-help guidebook improved quality of life for patients with irritable bowel syndrome July 2017

This study demonstrates that quality of life was improved for patients with irritable bowel syndrome (IBS) who received an IBS guidebook. This demonstrates the considerable importance of patient education in the effective management of IBS.


The coexistence of psychiatric and gastrointestinal problems in children with restrictive eating in a nationwide Swedish twin study August 2017

This large-scale study, looking at nearly 20,000 children in Sweden, found that those with restrictive eating habits were much more likely to have co-existing psychiatric or gastrointestinal conditions. This suggests that in children who present early with restrictive eating patterns it may be important to consider the possibility of co-occurring disorders.


 

19th August 2017

Low Food Allergy Prevalence Despite Delayed Introduction of Allergenic Foods - Data from the GUSTO Cohort – Asian populations July 2017
Recent research has suggested that early introduction of allergenic foods may be important in reducing the risk of developing food allergies. However, this hypothesis has not been explored in detail in Asian populations. This study explored the issue in a cohort in Singapore where food allergy rates are naturally low. Most of the infants in this study were reported to be first introduced to highly allergenic foods (such as eggs and peanuts at a late age (greater than 10 months). However, rates of food allergy to these foods between 1-3 years of age was very low. Early introduction of allergenic foods may thus not be necessary in populations in which overall food allergy prevalence is low. The main conclusion of this study is that allergy-related infant feeding advice needs to take into account the individual variations in different populations.

Can Early Omega-3 Fatty Acid Exposure Reduce Risk of Childhood Allergic Disease? July 2017
This interesting review study (full-text available) reviews the current state of the research looking at omega 3 consumption and the development of allergic disease. Consumption of oily fish and/or fish oils in pregnancy may reduce the risk of infants going on to develop allergic diseases. This is an important study that highlights a practical step pregnant women may want to take to reduce allergic risk in their offspring.

Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy. July 2017
Another study which looks at the link between vitamin D and food allergy. Lower levels of vitamin D in children were found to be associated with stronger immune responses to food allergens. This is an association study, so we cannot know whether vitamin D levels lead to changes in immune response, vice versa or that they are both mediated by some other independent factor. However, this evidence that an association exists is extremely interesting and is a promising avenue for more research to explore whether vitamin D could play a therapeutic role in children with food allergies.

Parents' and caregivers' experiences and behaviours when eating out with children with a food hypersensitivity. July 2017
The full text of this article is available to read and it touches on many issues, with regard to eating out with food allergies, which will be familiar to many families who try to negotiate this minefield. An interesting read and one which suggests that families of children with food allergies should be given education and strategies to help enable safe eating out experiences.

Donkey´s Milk Is Well Accepted and Tolerated by Infants with Cow´s Milk Food Protein-Induced Enterocolitis Syndrome (FPIES): A Preliminary Study July 2017
The summary of this article is not yet available online but the headline suggests an interesting potential alternative to cow’s milk in those with food protein-induced enterocolitis syndrome.

Celiac disease, non celiac gluten sensitivity and wheat allergy: comparison of 3 different diseases triggered by the same food. June 2017
This article (full-text available) provides an interesting review of the differences and similarities between these three different types of food sensitivity to wheat and gluten. Its aim is to provide a summary for primary health care professional to aid their recognition of these relatively common conditions.

 

 

 

 

23rd July 2017

A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: outcomes of a randomised controlled trial. July 2017
200 mothers of children with food allergy were recruited for this study. They were randomly allocated to two groups. One group received a single-session Cognitive Behavioural Therapy intervention including information on risk. The other group received no additional care. For those mothers who demonstrated high anxiety to begin with, the psychological intervention had a significant impact in reducing anxiety and levels of the stress hormone, cortisol. This promising study suggests some parents may benefit from this intervention which impacted on anxiety, risk perception and physiological stress response in mothers of children with food allergy.

Comparison of nutrient intake in adolescents and adults with and without food allergies. July 2017
This study assessed the nutrient intakes of adolescents and adults with food allergies compared to those without allergies. There were no differences in protein or energy intake between the groups and there was also no significant difference between the body mass index of individuals with and without food allergies. The food allergy participants had higher levels of some micronutrients. There were, however, low levels of various micronutrients across both participants, with and without food allergies, suggesting sub-optimal nutrition in both groups.

A History of Cow's Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren. July 2017
In this Finnish study, of nearly 200 ten-year olds, it is noted that children with cow’s milk allergy have significantly lower levels of vitamin D. This suggests measures should be taken to ensure adequate vitamin D intake in such children.

Nutrition and Allergic Diseases. July 2017
This interesting review article considers the many ways nutrition might be involved in the development of allergies. Some of the suggested mechanisms include: the diet of pregnant and breastfeeding women; the influence of food processing on allergenicity of food; modulation of gut bacteria. This gives insights into advice which may be useful to help reduce some of the risk factors associated with the development of allergies.

Timing of food introduction and atopy prevention. July 2017
Another study reviewing the current state of the evidence on the new research emerging that suggests that earlier introduction of allergenic foods may be instrumental in reducing the risk of food allergy development.

Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review. July 2017
This review study presents evidence to suggest that quality of sleep can be severely compromised in individuals with Atopic Dermatitis. In large part, this may be related to itching and scratching. Adequate control of symptoms is an important step to minimise sleep disturbance.

 

4th July 2017

Food allergy response capabilities of mothers and related factors. June 2017
How successfully food allergy can be treated in children depends, to a large part, on the parents’ ability to manage the dietary needs. This paper highlights the need for multidisciplinary support for parents to help them deal with the challenges of this condition.

"Healthcare seems to vary a lot": A focus group study among parents of children with severe allergy. June 2017
This study also looks at quality of life of families of children with allergies. It was felt that care differed according to many factors and that support and understanding was sometimes lacking. A more patient-centred approach is suggested.

Bullying and quality of life in children and adolescents with food allergy. June 2017
This review takes a look at evidence suggesting that children with food allergies are more likely to suffer from bullying. It is also reported that the specific nature of this bullying sometimes extends to being touched with foods to which they are allergic or having their food deliberately contaminated. This is a huge concern – particularly in the case of anaphylaxis.

Associations of self-reported allergic diseases and musculoskeletal problems in children: A US population-based study. June 2017
This survey, of nearly 1,000 children, reports that children with allergic diseases are more likely to suffer from bone, joint and muscle problems. Risk was found to increase with severity of allergic disease. Prospective studies will be important to help identify any causal role in this association.

Awareness of coeliac disease among chefs and cooks depends on the level and place of training. 2017
This study explored knowledge of gluten-free food preparation issues for coeliac disease in chefs, cooks and students in New Zealand. Half of the chefs had received no formal training regarding gluten-free food preparation. However, all were aware of the term ‘gluten-free diet’. A small minority (13%) had not heard of coeliac disease. Students were found to be significantly more aware of gluten-free food preparation, which hopefully means better training is now in place. Chefs from countries where coeliac disease is less common had a poorer knowledge of gluten-free food preparation and were less able to recognise gluten-containing foods. Individuals with coeliac disease should take care to choose restaurants with adequate knowledge and safety procedures in place.

 

24th June 2017

Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing. June 2017
This research study is by Kate Lawrence (of the Foods Matter team) and her colleague, Jeannette Hyde. It is a small-scale preliminary study exploring the influence of a dietary manipulation on physical and emotional wellbeing. The diet, designed to optimise gut bacteria, was found to reduce medical symptoms by 70%. Of specific note, digestive symptoms and emotion symptoms including depression and anxiety improved significantly following this month-long intervention. 8th June 2017

An update on the impact of food allergy on anxiety and quality of life. May 2017
This US-based study reports that ‘living with food allergy is associated with annual economic costs in excess of $4000 per child, in addition to risks of anxiety and depressive symptoms.’ Clinicians need to be aware of the significant burden and stress that living with food allergies places on individuals with food allergies and their families.

Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review. May 2017
There is not much research looking into the theory that eating baked egg or milk leads to quicker resolution of allergy to eggs or milk. This is despite increasing popular belief that eating these products accelerates desensitisation. The authors suggest that trials are needed to compare the resolution rates of baked-tolerant participants who are randomized to either eat or avoid baked egg or milk products.

Probiotic influences on allergic responses in mice. May 2017
This study explored the influence of lactic acid bacteria probiotics on allergic responses in mice. It was found that Bacillus coagulans was the most effective probiotic anti-allergenic strain and some of the mechanisms behind how this may work are explored. Read the full article.

Regulatory T Cells in Allergy and Asthma May 2017
This interesting review article considers the role of Regulatory T cells in food allergy and immunity.

Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases. May 2017
This study reports that infants found to have the microbe Clostridium difficile present in their stool samples were at a higher risk of developing allergic diseases, including food allergies in early childhood.

Histamine and Tourette’s syndrome – tics disappear in mice treated with histamine June 2017
We all know that the neurotransmitter, histamine, is associated with allergies but recent research suggests it may also play a role in a variety of neurological and psychiatric conditions too. In this study, scientists tried to create a mouse model of Tourette’s syndrome where the mice showed increased grooming behaviour. This excessive grooming behaviour was found to disappear when the mice were treated with histamine. Suggesting a possible mechanism that requires further investigation with regard to its role in treating tics. See here for a summary of the article and here for the academic summary.

 

 

 

8th June 2017

Elimination diet and the development of multiple tree-nut allergies. May 2017
Tree-nuts are often eliminated from the diet of multiple food-allergic patients, despite low probability for allergy. This study questions whether sensitivity to tree nuts might actually emerge during the elimination period in some patients.

Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy. April 2017
This study is the first to show that variations in a particular gene, the Th2 immune gene IL13, are associated with IgE mediated food allergies. This helps us to understand more about the mechanisms that may underpin food allergies.

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. April 2017
This population cohort study, based in Australia, sought to provide up-to-date statistics on the prevalence of allergies in early childhood. Amongst other findings, they reveal that 40-50% of this sample, of 5276 children, experienced symptoms of an allergic disease in the first 4 years of their life.

Disappearance of severe oral allergy syndrome following omalizumab treatment. May 2017
This single patient case-study reports the disappearance of oral-allergy response to apple following treatment with omalizumab. This offers promise that this treatment could be effective in reducing other types of allergic response and needs further exploration.

In-flight allergic emergencies. May 2017
This review article explores, in depth, various issues related to allergic and asthma related emergencies during air-travel. The full text of this article is available.

Coexistence of celiac disease & type 1 diabetes mellitus in children. Jan 2017
This research suggests a higher prevalence of type 1 diabetes in children with coeliac disease than in children without coeliac disease and suggests that regular screening should take place to pick up any cases as soon as possible.

Retrospective evaluation of pregnant women with celiac disease. March 2017
This study looked at the impact of coeliac disease on pregnant women. The presence of coeliac disease was found to be associated with a greater risk of miscarriage and premature births in mothers with coeliac disease. The importance of maintaining a gluten-free diet throughout this period is discussed.

Gastric bypass surgery radically improves subjects' gut biomes. May 2017
Gastric bypass surgery has been shown to be very effective in reducing the weight of obese individuals. It has been previously assumed that weight-loss was the result of less calories being absorbed because the areas of the gut involved most in food absorption are by-passed. However, this study shows that weight-loss may instead, in large part, result from a more diverse array of gut bacteria, which thrive as a result of reduced acidity.
For a more accessible write up, this report is great.

 

28th May 2017

Neurological manifestations of atypical celiac disease in childhood. April 2017
Learning disorders such as epilepsy, attention deficit hyperactivity disorder, and headaches could be the initial neurological manifestations of atypical CD. Eliminating gluten from the diet may improve neurological complaints, epileptic discharges, and neuropsychiatric symptoms in such patients.

Safety of Adding Oats to a Gluten-free Diet for Patients with Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. April 2017
In this systematic review of the research it was found that when individuals with coeliac disease added oats to their diets, their symptoms and blood results and biopsies were unaffected. This provides further evidence that glute-free oats may be safe for the majority of individuals with coeliac disease.

Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study May 2017
Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders including: mood disorders, anxiety disorders, eating disorders, behavioural disorders, ADHD, ASD, and intellectual disability. More research is needed to determine factors which may underlie this co-occurrence.

 

13th May 2017

Validation of Antibody-based Strategies for Diagnosis of Pediatric Celiac Disease Without Biopsy. April 2017
This study found that blood tests are highly predictive of biopsy results in children tested for coeliac disease.

Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy? April 2017
This study demonstrates a significant association between blood serum levels of tTG and duodenal biopsy results in patients with coeliac disease.  If these results are replicable, biopsy may not always be necessary in patients who have significant symptoms of the disease.

Coeliac disease: further evidence that biopsy is not always necessary for diagnosis. June 2017 (Epub ahead of publication)
More evidence that duodenal biopsy may not be necessary for the diagnosis of coeliac disease. When blood levels of IgA tTG were above a certain level (45 U/ml ) the predictive value of coeliac disease was100%. This had led to modifications in diagnostic guidelines in the Royal Derby Hospital, UK.

Coeliac Disease and Gastrointestinal Symptom Screening in Adult First-degree Relatives. April 2017
A significant number of adult first-degree relatives, of individuals with coeliac disease, demonstrated duodenal changes and/or gastrointestinal symptoms, even when blood tests for coeliac disease were negative.

Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity. April 2017
Calprotectin (a protein bio-marker for inflammation) can be detected in faeces and is found to have raised levels for individuals with inflammatory bowel disease, such as Crohn’s and ulcerative colitis. This study demonstrated that raised levels of calprotectin may also be associated with IgE food allergies.

Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. March 2017
This systematic review of research into ADHD and allergies, finds evidence that allergic diseases are significantly more common in children with ADHD than in children without ADHD. Full text available.

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children April 2017
This survey of 666 children, in the US, found higher rates of allergy amongst children who had been vaccinated. Vaccinated children were more likely to be diagnosed with allergic rhinitis (12.7%) than non-vaccinated children (0.4%). Vaccinated children were also more likely to suffer from allergies (22%) than unvaccinated children (7%) and more likely to require an allergy medication. The study was conducted on home-schooled children, who may differ in other ways to a random sample of the population. Nevertheless these striking results warrant further investigation.

 

 

 

 

 

 

 

30th April 2017

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. April 2017
Interesting consideration of how contracting a particular reovirus, alongside exposure to a potential allergen (such as gluten or egg), can trigger an intolerance to these foods. The effect the reovirus exerts on T-cells is thought to mediate this response.

Homeopathy for Allergic Rhinitis: A Systematic Review. Feb 2017
This article reviews the results of eleven trials of homeopathic remediesfor allergic rhinitis. ‘The single trial with reliable evidence had a small positive treatment effect without statistical significance.’ Due to the questionable quality of most of the research, the authors conclude that the usefulness of homeopathy for rhinitis remains unclear.

Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models. March 2017
This research looked at the influence of a probiotic (Bifidobacterium) on allergic inflammation in response to egg allergens in mice. This probiotic was found to inhibit the production of IgE (important in the allergic response) and to reduce allergic inflammation. This suggests a potential way of reducing allergic responses in humans and warrants further study.

Novel immunotherapy and treatment modality for severe food allergies. March 2017
Many patients with severe food allergy are unable to undergo regular immunotherapy, as the risk for a severe adverse reaction would be too great. Immunotherapy using very low doses may be safer for such patients and the authors suggest the need to consider patients allergy severity when determining they type of immunotherapy to try.

Growth of Children with Food Allergy March 2017
This review study finds that children with food allergies have stunted growth. This is found even when their nutritional needs are being met and when they are under the care of a dietician. This suggests further research is important to enable exploration of the reasons for growth faltering in children with food allergies.

Impact of school peanut-free policies on epinephrine administration. March 2017
This US study assessed rates of Epi-pen administration in all Massachusetts public schools between 2006 and 2011. Interestingly, whether or not schools implemented no-peanut policies, was found to have no effect on epinephrine administration rates.

 

15th April 2017

The evidence base for efficacy of the low FODMAP diet in irritable bowel syndrome: is it ready for prime time as a first-line therapy? March 2017
This review suggests that the FODMAP diet is effective in reducing symptoms in approximately 70% of patients with IBS and is therefore an appropriate first-line therapy for such patients.

The clinical value of breath hydrogen testing for FODMAP sensitivity. March 2017
This article discusses the usefulness of breath testing for identifying patients who are sensitive to high FODMAP foods (including fructose and lactose). It is suggested that many patients experience symptoms when consuming fructose and lactose that can’t be detected using the breath testing. This questions the validity and usefulness of such tests for the diagnosis of functional bowel disorders.

Low FODMAP in 2017: Lessons learned from clinical trials and mechanistic studies. April 2017
This review article highlights the mounting evidence supporting use of the low FODMAP diet in patients with IBS. There are still many unknowns though, regarding any short or long term effects it may have on important factors such as gut bacteria and overall nutrition.

The Low FODMAP Diet: Many Question Marks for a Catchy Acronym March 2017
This review article (full text available) questions the reliability of some of the evidence supporting the low FODMAP diet and also questions whether it may result in nutritional deficiencies due to reduced intake of fibre, calcium, iron, zinc, folate, B and D vitamins, and natural antioxidants. Clearly more investigation in this area is needed.

How to institute the low-FODMAP diet. March 2017
In implementing the low FODMAP diet, many prebiotics are restricted. This means that the good bacteria in the gut may not be fed sufficiently and this may impact negatively on the diversity of healthy gut bacteria. It is therefore suggested, in this article, that once symptom relief is achieved with this diet, the re-introduction of pre-biotic foods should be attempted and dieticians should be encouraging this in their patients.

Dietary interventions for recurrent abdominal pain in childhood. March 2017
Treating recurrent abdominal pain in children, where no known cause for the symptoms can be identified, is a tricky matter. Here authors review 19 studies of interventions in such children, in order to see which treatments seem to be the most successful in reducing pain. They find some evidence to support the use of probiotics in such children as being beneficial for pain reduction. There was a scarcity of studies looking at exclusion diets, including the low FODMAP diet, which are much needed in this age-group.

Review of the effects of fermented milk with healthy bacteria on gastrointestinal discomfort in the general adult population. Jan 2017
Similar to the above study on children, this review identifies small, but consistent improvements in abdominal pain in adults with gastrointestinal discomfort when treated with probiotics, in this case fermented milk with Bifidobacterium lactis (B. lactis) CNCM I-2494 and lactic acid bacteria. (Full text available).

 

2nd April 2017

Impact of elimination diets on nutrition and growth in children with multiple food allergies. March 2017
This review looks at growth and nutrition in children with multiple food allergies. Growth needs to be considered from the point of view of multiple exclusions but also from the perspective of inflammation which can impact the absorption of nutrients.

Update on Timing and Source of 'Allergenic' Foods. March 2017
This interesting paper discusses research looking at the early introduction of allergenic foods, stating that there is no need to delay this. However, they also importantly note that some infants are sensitised foods even before any solid is introduced.

A Limited Survey of Dark Chocolate Bars Obtained in the United States for Undeclared Milk and Peanut Allergens. March 2017
This US study reveals that ‘a large proportion of dark chocolate bars contain undeclared milk.’ Cautionary note to food allergy sufferers.

The impact on quality of life on families of children on an elimination diet for Non-immunoglobulin E mediated gastrointestinal food allergies. Feb 2017
This study (full-text available) demonstrates the profound impact of non IgE mediated food allergies on quality of life for parents of children with this condition. Quality of Life and family functioning was worse in those families who had a child on an elimination diet for non-IgE mediated allergies compared to those with sickle cell disease and intestinal failure, highlighting the impact this disease has on families.

Anaphylaxis in Schools: Results of the EPIPEN4SCHOOLS Survey Combined Analysis. March 2017
This US-based study explored the use of Epi-pen auto-injectors in schools. One of the most important findings from this study is that: 25% of the cases of anaphylaxis occurred in individuals with no previously known allergies. This suggests the immense importance of having auto-injectors available to treat the general population, as in the EPIPEN4SCHOOLS program.

Eczema Relief: Probiotic Lotion Shows Early Promise March 2017

Next Generation: Personalized Probiotic Skin Care February 2017
Scientists treat Staphylococcus aureus skin infections using lotions made with bacteria from atopic dermatitis patients’ own microbiomes.

Bacterial Spray Promising for Keratosis Pilaris. March 2017
Topical Nitrosomonas eutropha improved skin texture in small trial

 

17th March 2017

Coeliac disease in the 21st century: paradigm shifts in the modern age. March 2017
This article discusses the many changes in the presentation and diagnosis of coeliac disease that have occurred in recent years. Malnutrition and malabsorption used to be key defining factors but coeliac disease now affects as many overweight individuals as those who are underweight. The increasing incidence of the disease is also discussed, along with the issue of dealing with people with minimal symptoms who have been diagnosed with the condition.

Non-coeliac gluten sensitivity. March 2017
Gluten sensitivity in individuals without coeliac disease is now widely reported but we still know little about the mechanisms underlying this sensitivity. This review article explores some of the possible underpinning factors and reveals how little we still know about the diagnosis, causes, therapeutic approaches and outcomes for patients with non-coeliac gluten sensitivity. 

Gluten-induced cognitive impairment ("brain fog") in coeliac disease. March 2017
This article reports information regarding cognitive symptoms associated with brain fog in patients with coeliac disease. The researcher asserts that these symptoms have a scientific basis and that they resolve with a gluten-free diet. However, the exact mechanism by which brain fog may come about is poorly understood.

Calcium in Gluten-Free Life: Health-Related and Nutritional Implications. July 2016
Calcium deficiency is frequently observed in patients with coeliac disease. Here researchers explore the possible reasons for this and what can be done to help patients achieve adequate calcium intake. Full article available.

Risk of Cross-Contact for Gluten-Free Pizzas in Shared-Production Restaurants in Relation to Oven Cooking Procedures. Sept 2016
Many gluten-free consumers will have eaten gluten-free pizza in restaurants and wondered about the risk of cross-contamination. This study explored the process of cooking gluten containing and gluten-free pizzas in restaurants in Italy. It concludes that when specific recommendations are adhered to it can be safe to cook both types of pizza within the same oven. However, differing individual sensitivity may have a bearing on the safety for any particular consumer.

Oral manifestations of gastrointestinal diseases in children. Part 4: Coeliac disease. Dec 2016
Many children with coeliac disease may also experience oral manifestations of the condition. This article suggests that children with coeliac disease more frequently suffer from poorly formed tooth enamel and mouth ulcers than other children. Detection of these symptoms could be a warning sign for further investigations. Do we need to educate dentists to spot these symptoms and suggest children for follow-up?

5th March 2017

The emotional, social, and financial burden of food allergies on children and their families. March 2017
This article reviews research looking at the emotional, social, and financial impact of food allergy on children and their families. The significant impact on children and families in each of these areas suggests that a multidisciplinary approach is critical to helping families cope with the multitude of issues that can result from food allergies.

Probiotics improve quality of life for seasonal allergy (e.g. hay fever) sufferers.
Feb 2017
This study treated patients with seasonal allergy with a combined probiotic and reports that self-reported quality of life significantly improved when taking the probiotics. The mechanism for this improvement is unknown.

Food Allergy Knowledge and Attitudes of Restaurant Managers and Staff. Sept 2016
Data was collected for this study from 278 randomly selected restaurants through interviews with restaurant managers, food workers, and servers. Results indicated that these restaurant workers were generally knowledgeable about food allergy. However, there was some cause for concern that more than 10% of managers and staff believed that a person with a food allergy can safely consume a small amount of that allergen. See here for the full study report.

Food Protein-Induced Enterocolitis Syndrome. Feb 2017
A useful review article (full-article available to read) looking at our current knowledge of Food Protein-Induced Enterocolitis Syndrome (FPIES). More research is suggested, given that our understanding regarding pathophysiology in this condition is limited as is the development of therapeutic approaches.

Safety and feasibility of heated egg yolk challenge for children with egg allergies. Feb 2017
This study looked at whether children who are allergic to cooked egg were able to eat cooked egg yolk alone. It was found that, among 919 patients, only 17% reacted when given an oral cooked egg yolk challenge in hospital. This suggests that the majority of children who are allergic to cooked egg, may safely be able to eat egg yolk. Such challenges should be conducted in hospital for safety. This may be a helpful way to increase variety and nutrition in the diets of food allergic children.

Review suggests that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to infants' diets. Feb 2017
More research to suggest that feeding infants allergenic foods early in life may be linked to a better ability to tolerate these foods.

 

16th February 2017

That Valentine's day kiss.... Not so simple, or so romantic, if you have a food allergy.... Kate Lawrence looks at some of the research around allergic reactions that have been triggered by a kiss. February 2017

 

5th February 2017

Food-Allergic Adolescents at Risk for Anaphylaxis: A Randomized Controlled Study of Supervised Injection to Improve Comfort with Epinephrine Self-Injection Jan 2017
Training adolescents to self-inject (using an empty syringe) greatly increased confidence levels in ability to self-medicate with their Epi-pen. Training is an important factor in enabling adolescents and young adults to manage their condition.

Yogurt consumption in infancy is inversely associated with atopic dermatitis and food sensitization at 5 years of age: a hospital-based birth cohort study. Jan 2017
This study looked at regular consumption of yoghurt in infancy in over 1,500 children. It was found that the children who regularly consumed yoghurt were less likely to develop food sensitivities or atopic dermatitis at 5 years of age. This shows a useful preventative step that can be taken to reduce the chances of developing food allergies. The Full text is article for free.

Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre. Jan 2017 This study assessed vitamin D levels in children with gastrointestinal food allergy at Great Ormond Street Hospital. It was found that children with non-IgE mediated gastrointestinal food allergy are at risk of vitamin D insufficiency and deficiency. The Full article is available for free.

The Establishment of Cow's Milk Protein Allergy in Infants is Related with a Deficit of Regulatory T cells (Treg) and Vitamin D. Jan 2017
Establishment of Cow’s Milk Protein Allergy (CMPA) in infants was related with lower Regulatory T cells and vitamin D levels. These immune alterations could be crucial factors behind the CMPA establishment and they could constitute a therapeutic target for treatment of CMPA.

Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. Oct 2016
This study explored response to Epicutaneous immunotherapy - a method used to induce desensitization in allergic patients by delivering allergens through the skin. The therapy was safe and associated with a modest treatment response after 52 weeks, with the highest responses among younger children. There was a high adherence and retention rate and significant changes in immune pathways, which supports further investigation of this novel therapy.

Irritable bowel syndrome and diet. Jan 2017
This article reviews the available dietary interventions for IBS and will considers the evidence for nutrition-based therapies (including the low FODMAP diet) to treat this condition.

Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome (IBS). Oct 2016
The findings of this study support the efficacy of a Low FODMAP diet in alleviating IBS symptoms, and show changes in inflammatory cytokines, microbiota profile, and SCFAs, which may have consequences for gut health. The diet induces improvement in IBS symptoms according to self-report and the biological measures may shed some light on the mechanisms behind how the diet may produce these benefits.

 

 

19th January 2017

Coeliac disease: a unique model for investigating broken tolerance in autoimmunity. Nov 2016
Interesting review article explaining that we know lots about the many of the steps involved in the development of Coeliac Disease. Despite this wide knowledge, surprisingly little is still known about how and why tolerance to gluten might break down in the first place.

The progression of coeliac disease: its neurological and psychiatric implications. Dec 2016
This review articles explains the possible neurological consequences of Coeliac Disease and highlights some common psychiatric symptoms that occur in untreated Coeliac Disease: depression, schizophrenia and anxiety. A gluten-free diet plays an important role in reducing neurological and psychiatric complications.

Extensively hydrolysed casein formula containing L. rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial. Dec 2016
Adding a probiotic to hydrolysed infant formula, for infants with cow’s milk allergy significantly reduced the risk of developing further allergies. Exciting therapeutic potential.

Efficacy and safety of high-dose rush oral immunotherapy in persistent egg allergic children: A randomized clinical trial. Jan 2017
Oral immunotherapy is a very time consuming business. This study explored the efficacy of ‘Rush Oral Immunotherapy’ (ROIT) for egg allergy. 32 children underwent an intensive 5-day desensitisation protocol followed by a five month maintenance phase where egg was consumed every 48 hours. 5-day egg ROIT successfully desensitized 94% of the allergic patients.

Safety and Efficacy of Low-Dose Oral Immunotherapy for Hen's Egg Allergy in Children. Jan 2017

Further research evidence to suggest that oral immunotherapy for egg allergy is both safe and effective. Low-dose OIT induced sustained unresponsiveness to 1/32 and 1/2 of a whole egg, with no severe symptoms. To improve food allergies, continuous intake of small amounts of these foods may be as effective as the consumption of larger quantities.

 

8th January 2017

Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy. December 2016
Patients with food allergies are more likely to go on to develop atopic dermatitis in adulthood than individuals without food allergies.

An Examination of the Food Allergy Quality of Life Questionnaire Performance in a Countrywide American Sample of Children: Cross-Cultural Differences in Age and Impact in the United States and Europe. December 2016
Food allergy related quality of life rated worse by American than European children.

Consultation with registered dietitian to prevent accidental reactions to food: insight from an egg allergy influenza vaccination cohort. December 2016
Consultation with a dietician reduces the risk of accidental exposure to egg allergen and is therefore useful in treating patients with food allergy.

Peanut allergy as a family project: social relations and transitions in adolescence. December 2016
This interview study revealed the impact on adolescents and their families of dealing with peanut allergy. Understanding of allergy in the wider social network is important to aiding the transition to independence.

Allergic sensitization in kidney transplanted patients - Is it a result of immunosuppressive agents or sensitization of the living donor? December 2016
This study supports the concept that not only immunosuppressant agents but also sensitization of living donors could be a significant contributor to allergic sensitization in kidney recipients.

Allergic Sensitization at School Age is a Systemic Low-grade Inflammatory Disorder. December 2016

Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis. December 2016
This study reports an increased risk of Thyroid Disease in patients with Coeliac Disease, suggesting that it may important to screen patients with Coeliac Disease for thyroid problems. The authors suggest that the effect of a gluten-free diet on Thyroid Disease requires further investigation.

 

11th December 2016

Food Allergy in Atopic Dermatitis.
November-December 2016
There is a great deal of controversy and disagreement surrounding the potential of food allergy to be a cause of atopic dermatitis. Many allergy specialists believe it may play a role, whilst some dermatologists remain less convinced. This article reviews the current scientific evidence and suggests that avoidance of proven food allergens could be beneficial in Atopic Dermatitis.

Randomized Controlled Trial of Oral Immunotherapy for Egg Allergy.
December 2016
Another study looking at whether oral immunotherapy can help increase tolerance to food to which an individual is allergic. This study found promising results: half of the participants who received immunotherapy were able to tolerate a small amount off egg protein, compared to none of the participants who received no treatment.

Low FODMAP Diet for treating IBS
October 2016
The low FODMAP diet has been increasingly used in recent years to treat patients with Irritable Bowel Syndrome (IBS) and those with multiple food intolerances and unexplained gastrointestinal symptoms. The low FODMAP diet restricts the consumption of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs). This study compared the efficacy of the Low FODMAP diet to the modified National Institute for Health and Care Excellence guidelines (from the US) on symptoms in patients suffering from IBS and diarrhoea. The low FODMAP diet led to significantly greater improvement in individual IBS symptoms, particularly pain and bloating.

Lupin and Other Potentially Cross-Reactive Allergens in Peanut Allergy.
November 2016
Lupin sensitization is reported in 15-20% of individuals with peanut allergy. This article reviews current understanding of this cross-reactivity.

Introducing Allergenic Food into Infants' Diets: Systematic Review.
November 2016
This evidence-based review explores the association between timing of introduction of potentially allergenic foods to infants and development of food allergies. ‘Results found that delayed introduction of solid foods in general and allergenic foods in particular was not associated with decreased risk for allergic diseases among high and low-risk infants. Later introduction was associated with increased risk for allergy development.’ The authors make some interesting practical suggestions based on their findings… ‘For infants at low risk for development of food allergies, providers should advise caregivers to introduce potentially allergenic foods with other solid foods between 4 and 6 months of age when children show an interest in eating solids. Caregivers of infants at high risk for development of food allergies are recommended to introduce peanuts between the ages of 4 and 6 months and work with providers to create an individualized plan for introduction of other allergenic foods.’

 

27th November 2016

Gut microbes in babies – associated with development of allergies
September 2016
This research demonstrates that the types of microbes (bacteria) present in the gut of infants seem to be associated with predisposition to going on to develop allergies. Children with a particular type of microbes were three times more likely to go on to have allergic reactions and asthma compared to children with different mixes of microbes. The researchers suggest that this association may result from the microbes triggering an immune response which supresses cells that normally keep allergic reactions in check. Possibly this could be used to inform preventative medicine – if babies can be exposed to the most beneficial bacteria this may lower their risk of allergies.
Interesting commentary in the Guardian.

Special Issue on Coeliac Disease. United European Gastroenterology Journal
March 2015
A special issue that was published last year, but is worth looking at for those interested in coeliac disease. An entire issue of this journal is dedicated to coeliac disease covering topics such as:

  • Screening for celiac disease in the general population and in high-risk groups
  • Psychological morbidity of celiac disease: A review of the literature
  • Non-coeliac gluten sensitivity: piecing the puzzle together

Food allergies in the elderly
November 2016                                   
Many of us may immediately think of children or young people when considering food allergies. However, such allergies are also a problem for older adults and this review explains how other health concerns in this age group may make them particularly vulnerable to allergic reactions.

Pre- and probiotics for allergy prevention: time to revisit recommendations?
October 2016
‘Recent guidelines from the World Allergy Organization recommend the use of probiotics for the primary prevention of eczema in pregnant and breastfeeding mothers of infants at high risk for developing allergy and in high risk infants.’ Probiotics are a source of beneficial bacteria that are introduced into the gut through oral consumption. This article discusses some of the issues around our current understanding of the research informing this advice.

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization.
January 2017 (published online ahead of print)
This study explored the efficacy of oral immunotherapy in children allergic to cow’s milk. The procedure involved giving tiny doses of milk that had been treated at a high temperature every week. The procedure was safe and effectively desensitised 70% of the children to milk. This is another promising finding for food immunotherapy; maybe it will move from clinical trials to clinical practice in the future. In the meantime, it is not safe to try this type of therapy on your own at home.

 

 

12th November 2016

A pill to treat coeliac disease? Not quite – here’s what the science says
October 2016
Well explained journalistic article about research into a pill that is being investigated that may alleviate some of the symptoms of gluten-ingestion in individuals with coeliac disease or non-coeliac gluten-sensitivity. The pill, GluteGuard, contains a natural enzyme found in papaya which has the ability to break down proteins, including gluten. Initial results are promising and suggests further research into this enzyme is needed.

Managing the pediatric patient with celiac disease: a multidisciplinary approach
October 2016
This article talks about the importance of a multi-disciplinary approach for managing coeliac disease in children.

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals
November 2016

Great review article about the influence of probiotics and prebiotics on brain function, emotion and thinking. Probiotics (beneficial gut-bacteria) and prebiotics (which feed the bacteria) are being increasingly investigated regarding their role in allergy prevention and treatment. It is interesting to note that there is also increasing evidence that these friendly bacteria are involved in brain function and mental health. This article reviews both animal and human research which suggests that manipulating gut bacteria, to increase the number and activity of beneficial bacteria, improves cognitive function and mood. Pro-biotics appear to achieve similar results to some anti-depressants for example, in terms of improving mood and reducing anxiety. The potential for using such supplements for treating mental health conditions is immense.

Skin patch could help kids with peanut allergies
November 2016
This study suggests that the use of a skin patch, which releases small amounts of peanut protein, may be helpful in improving tolerance to peanuts.

Detection of major food allergens in amniotic fluid: initial allergenic encounter during pregnancy. November 2016
It was previously been thought that early sensitisation to food in infants occurs through ingestion of food particles in the mother’s breastmilk. However, this study found that food allergens are also present in amniotic fluid, suggesting a different (and earlier) mechanism by which infants may become sensitised.

The ingestion of cow’s milk formula in the first 3 months of life prevents the development of cow’s milk allergy
October 2016
This retrospective study suggests that drinking cow’s milk formula (either exclusively or alongside breastfeeding) in the first few months of life, is associated with a lower risk of developing cow’s milk allergy. The claim of the title is a little strong but the research suggests that further research into early exposure of allergens is much needed.

 

 

29th October 2016

Is there a relationship between gluten sensitivity and postural tachycardia syndrome? (Abnormal increase in heart rate that occurs after sitting up or standing causing dizziness or fainting) Dec 2016 (Epub ahead of print)
This study found a higher incidence of both coeliac disease and self-reported gluten-intolerance in patients with postural tachycardia syndrome (PoTS). It is the first study to propose a relationship between gluten sensitivity and PoTS, suggesting future research into the co-occurrence of these conditions is necessary.

IgE cross-reactivity of peanut with walnut and soybean in children with food allergy. October 2016
More research needs to be done to fully establish cross-reactivity but the researchers of this study suggest that, individuals who are allergic to peanuts should be cautious about consuming walnuts and soybeans. There is a high chance they may be allergic to these foods in addition to peanuts.

Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties. October 2016
This is an animal study, which looks at the effects of probiotics in mice. It was found that probiotics were able to reduce allergic airway inflammation in mice. Results such as these are exciting, as they suggest potential future treatments that may be able to be applied to humans.

Does concurrent breastfeeding alongside the introduction of solid food prevent the development of food allergy? October 2016
This study found no evidence that introducing solids, or food allergens, whilst breastfeeding has an allergy-preventative effect.

Omalizumab facilitates rapid oral desensitization for peanut allergy. September 2016
This study presents more promising results for oral immunotherapy to peanuts. Researchers used a medication called Omalizumab, alongside oral immunotherapy, and found that this increased the amount of peanut protein that could be tolerated. A very promising study, that may provide additional treatment options in the future.

 

 

15th October 2016

Assessment of IgE-mediated food allergies in children with atopic dermatitis. September 2016
More than one quarter of children with atopic dermatitis were found to have food allergies. The researchers suggest that all children with atopic dermatitis should be screened for food allergy.

Australian researchers are a step closer to a peanut allergy vaccine. September 2016
A combined therapy of peanut protein and probiotics led to 80% of allergic children being able to consume peanuts. Exciting research to get involved in for anyone living in Australia.

Giving antibiotics to children increases allergy risk September 2016
Findings were recently presented at the European Respiratory Society International Congress in London. These suggest that the risk of developing both asthma and hay fever increases in children exposed to antibiotics early in life. This research has the potential to guide clinical practice in terms of encouraging more judicious use of antibiotics and also looking at how we might mitigate the disruption to healthy gut bacteria caused by antibiotics.

Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis. September 2016
This review, of multiple research studies into food allergy, found that early introduction of egg and peanut is associated with a lower risk of developing allergies to these foods.

Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. September 2016
Around one third of patients with Irritable bowel syndrome (IBS) saw a significant improvement in symptoms on a gluten-free diet.

Human milk oligosaccharides and development of cow's milk allergy in infants. September 2016
These substances, which occur naturally in human breast milk, are important in the development of healthy gut bacteria in infants. Babies who received human milk with low levels of oligosaccharides were more likely to be effected by cow’s milk allergy. This study might provide useful clues for future preventative measures.

Safety profile of oral immunotherapy with cow's milk and hen egg: A 10-year experience in controlled trials. September 2016
Some encouraging results regarding desensitisation to egg and milk allergens using oral immunotherapy.

 

30th September 2016

Active treatment for food allergy.
Kobernick AK, Burks AW.
Allergol Int. 2016 Sep 13. pii: S1323-8930(16)30108-3. doi: 10.1016/j.alit.2016.08.002. [Epub ahead of print] Review.
This article reviews current research into treatments for food allergy, largely focusing on immunotherapy. Methods reviewed include subcutaneous immunotherapy, oral immunotherapy and epicutaneous immunotherapy. There are promising results from trials for various foods; however, the most effective methods have a higher safety risk. Research into food allergy prevention is also reviewed. Full article available here for free…

Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases.
Martin VJ, Shreffler WG, Yuan Q.
Am J Case Rep. 2016 Aug 29;17:621-4.

This article reviews four individual cases of infants with milk protein intolerance. These infants were given a probiotic (Lactoacillus rhamnosus GG) and the symptoms of their milk protein intolerance resolved within 7-28 days. This presents an exciting alternative to dietary restriction in infants with milk protein intolerance. Full article available here for free…

Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment.
Königs A, Kiliaan AJ.
Neuropsychiatr Dis Treat. 2016 Jul 26;12:1869-82. doi: 10.2147/NDT.S68652. eCollection 2016. Review.

Lower levels of omega-3 fatty acids are found in blood samples of individuals with ADHD compared to individuals of the same age without ADHD. These authors review 25 research studies that have assessed whether giving omega-3 supplements to children with ADHD produces any improvement in symptoms. The studies produce differing results, but overall there seems to be evidence that omega-3 supplements can help alleviate the severity of the symptoms in ADHD, and may be especially helpful in patients with mild forms of ADHD. Given that the supplement is very safe, with few reported side-effects, it may well be worth a try before stimulant medications, which are associated with severe side-effects for some individuals. Full article available here for free…

Gluten contamination in gluten-free bakery products: a risk for coeliac disease patients.
Farage P, de Medeiros Nóbrega YK, Pratesi R, Gandolfi L, Assunção P, Zandonadi RP.
Public Health Nutr. 2016 Sep 15:1-4. [Epub ahead of print]
One fifth of gluten-free bakery products in Brazil were found to be contaminated with gluten. The majority of bakeries sampled were found to have at least one contaminated product. Research summary available here…

Celiac Disease and Epilepsy: The Effect of Gluten-Free Diet on Seizure Control.
Bashiri H, Afshari D, Babaei N, Ghadami MR.
Adv Clin Exp Med. 2016 Jul-Aug;25(4):751-4. doi: 10.17219/acem/43585.
In this study, 6% of patients with epilepsy tested positive for coeliac disease. These patients were put on a gluten-free diet. After 5 months, 5 out of the 6 patients who had epilepsy and coeliac disease had their seizures completely under control and were able to discontinue anti-epileptic medications. Full article available here for free…

Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics.
Grossi E, Melli S, Dunca D, Terruzzi V.
SAGE Open Med Case Rep. 2016 Aug 26;4:2050313X16666231. doi: 10.1177/2050313X16666231. eCollection 2016.

This reports a case-study of a single patient with autism and coeliac disease. Treatment with probiotics reduced severity of abdominal symptoms but, interestingly, also led to an improvement in autistic symptomatology. Full article available here for free…

 

 

Earlier reports collated by John Scott.

13th April 2016

Patients with celiac disease may have normal weight or may even be overweight. Only one third of patients with CD in this study had a low BMI. February 2016

The coexistence of coeliac disease and ulcerative colitis is extremely rare in childhood. However, ulcerative colitis should be considered in coeliac children on restrictive gluten-free diet with persistent diarrhoea or bleeding from lower gastrointestinal tract. January 2016

More than 50% of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry. April 2016

Wheat allergy: diagnosis and management - possibly with immunotherapy. January 2016

Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. February 2016

Delivery by Caesarean section predisposes to development of food allergy but not atopic dermatitis in early childhood. February 2016

New website, AllergenOnline.org provides access to a peer reviewed allergen list and sequence searchable database intended for the identification of proteins that may present a potential risk of allergenic cross-reactivity.

Australian-born children more prone to allergies than those born in Asia. February 2016

Both organic milk and meat contain around 50% more beneficial omega-3 fatty acids than conventionally produced products. February 2015

IgE to novel citrus seed allergens among cashew allergic children. February 2016

Oral immunotherapy for peanut allergy induces eosinophilic esophagitis: three pediatric case reports. February 2016

Dying Epithelial Cells Regulate the Immune System: Finding Could Aid Treatment of Inflammatory and Allergic Diseases. February 2016

31st March 2016

Identification and molecular characterization of oat peptides implicated on coeliac immune response. February 2016

A large variety of clinical features and concomitant disorders in celiac disease - A cohort study in the Netherlands. January 2016

Different Gene Expression Signatures in Children and Adults with Celiac Disease. February 2016

The opioid effects of gluten exorphins: asymptomatic celiac disease. November 2015

Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten Challenge. February 2016

Current evidence summarised which shows that human mast cells play a central role at the GI barrier, both in health and disease. February 2016

Could the food we eat affect our genes? Study in yeast suggests this may be the case. February 2016

Recent studies suggest that early rather than late introduction of allergenic foods reduces the risk of food allergy. The preferred timing of food introduction might be sooner than the current recommendation, and might apply not only to high-risk infants. April 2016

Diagnosis and treatment of pediatric food allergy: an update 2015

American adults with allergies, especially to nuts and seasonal pollen, have low diversity, reduced Clostridiales, and increased Bacteroidales in their gut microbiota. November 2015

Limited evidence to support maternal n-3 LCPUFA supplementation during pregnancy and/or lactation for reducing allergic disease in children. July 2015

17th March 2016

Long-term follow-up of oral immunotherapy for multiple food allergies suggest that tolerance can be maintained when subjects continue to consume the allergens regularly. March 2016

Optimal needle length for an Epinephrine auto-injectors (EAI) for infants weighing 7.5 to 15kg should be shorter than the needle length in current, commercially available pediatric EAI, in order to avoid striking the bone and possible intraosseous injections. March 2016

Meta review suggests that there is no consistent advantage to using a hypoallergenic formula over a standard formula for preventing the development of cow's milk allergy in high risk infants. March 2016

Shellfish and house dust mite allergies: is the Link Tropomyosin? March 2016

Peanut exposure in public settings is most likely to occur by contact with surfaces harboring allergens rather than by inhalation, even in peanut-rich environments. March 2016

Coconut oil – a nutty idea? A report in the Nutrition Bulletin suggesting that coconut oil's high saturated fat content may still make it a risk for cardiovascular disease although this link is now being re-exmined. Also pointing out that there is, as yet, very little human research into the benefits or otherwise of coconut oil consumption. February 2016

Three novel candidate probiotic strains with prophylactic properties in a murine model of Cow's Milk Allergy. January 2016

Changes in gut microbiota may lead to activation of an inflammatory pathway and thereby to coeliac disease. January 2016

Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011-2012. January 2016

Dietary management of peanut and tree nut allergy: should peanut allergic patients always avoid products with 'may contain nuts' warnings? April 2015

Allergic reactions to pine nuts: a review. 2015

Egg allergy in adolescent and adult patients suffering from atopic dermatitis. March 2015

 

20th February 2016

Association of ADHD and Celiac Disease: no conclusive evidence. January 2016

From coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free? March 2016

Apparently asymptomatic sufferers of coeliac diseases very often develop diseases that can be related with gluten intake. Gluten can be degraded into several morphine-like substances – gluten exorphins. These compounds have proven opioid effects and could mask the deleterious effects of gluten protein on gastrointestinal lining and function. November 2015

Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016

Just under half the infants with confirmed food hypersensitivity, studied as part of Euro Prevall birth cohort study, had no demonstrable IgE. January 2016

Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. January 2016

Most egg allergic children can tolerate high protein baked egg products. January 2016

Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. January 2016

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T-cell populations that may help researchers determine which people will respond well to the therapy. January 2016

A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges. June 2015

How normal diet establishes immune tolerance conditions in the small intestine. January 2016

Except when fermentation or hydrolysis are used, food processing does not alter the allergenic properties of food proteins so as to reduce their allergenic potential. June 2015

A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity. December 2015

 

7th February 2016

Celiac Disease and Drug-Based Therapies: Inquiry into Patients Demands. January 2016

Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification. January 2016

Rare association of celiac disease with myasthenia gravis in a patient with other immune disorders: A case report. January 2016

Contemporary celiac disease diagnosis: is a biopsy avoidable? March 2016

Clinical presentation, allergens, and management of wheat allergy. January 2016

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity. January 2016

Safety, clinical, and immunologic efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy. October 2015

Scientists find evidence for congenital food allergies in umbilical cord blood. January 2016

New approach for food allergy management using low-dose oral food challenges and low-dose oral immunotherapies. January 2016

Limiting infants to almond milk can result in scurvy. January 2016

23rd January 2016

Gluten Introduction and The Risk of Coeliac Disease. A Position Paper By The European Society For Paediatric Gastroenterology, Hepatology & Nutrition. January 2016

Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children. December 2015

Frequency of Celiac Disease in Patients With Increased Intestinal Gas (Flatulence). October 2015

Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. June 2015

Malrotation of midgut in adults, an unsuspected and neglected condition-An analysis of 64 consensus confirmed cases. Abnormal duodenojejunal junction (DJJ) was a consensus finding in 64 cases referred for RAP (recurrent abdominal pain). Most were in their fourth decade of life, and 12 were over 60. Besides RAP, intolerance to food was the next common symptom. November 2015

Effects of Egg White Consumption on Immune Modulation in a Mouse Model of Trimellitic Anhydride-induced Allergy. This study shows that the consumption of egg white by allergic mice did not increase their allergic response. June 2015

Food allergies developing after solid organ (liver, heart, lung, kidney, and intestinal) transplant. December 2015

Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial: a critical appraisal. November 2015

High maternal consumption of milk products during pregnancy may protect children from developing CMA (cow's milk allergy), especially in offspring of non-allergic mothers. January 2016

Cord Blood Cells Foretell Food Allergy. January 2016

Worrying number of parents do not know how to give an emergency epinephrone or adrenaline shot. January 2016

The Role of Helminth Infection and Environment in the Development of Allergy: A Prospective Study of Newly-Arrived Ethiopian Immigrants in Israel. The increased allergy among immigrants one year after immigration may reflect the combined influence of the decreased helminth load as well asnovel environmental factors. January 2016

Childbirth and consequent atopic disease: emerging evidence on epigenetic effects based on the hygiene and EPIIC (Epigenetic Impact of Childbirth) hypotheses. January 2016

9th January 2016

The ever-increasing number of coeliac disease-related liver injuries suggest the wisdom of testing for CD in cryptogenic hepatobiliary conditions where the relationship with CD has not yet been fully investigated. November 2015

Risk of venous thromboembolism in patients with celiac disease: A systematic review and meta-analysis shows a signifcantly increased risk. December 2015

The high prevalence of coeliac disease in children with Type 1 diabetes emphasizes the need for routine screening programs to be in place for these high-risk populations. December 2015

High prevalence of celiac disease among first-degree relatives of Indian celiac disease patients. November 2015

It may be possible to tailor gluten for the production of hypoallergenic flours while still taking advantage of its unique viscoelastic properties. December 2015

The overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: a clinical dilemma. December 2015

Researchers find link between processed foods and autoimmune diseases. December 2015

Recent studies suggest anti-histamine therapy might efficiently combat inflammation in atopic dermatitis. December 2015

Timing of routine infant vaccinations may be relevant to the risk of food allergy and eczema at one year of age. December 2015

Because of the growing restrictions on the use of bisphenol A in food contact materials, several bisphenol analogs are now being used instead. A way of identifying them. November 2015

The alternatives to BPA that are being used in the manufacture of “BPA-free” products are not necessarily safer. December 2015

Emotional and behavioral problems, particularly symptoms of depression, anxiety, and ADHD are common among adolescents with food allergy. December 2015

Challenge with instant skim milk powder could be a safe, convenient and easily standardizable alternative to home baked food for heated milk challenge. December 2015

Breast feeding, although conferring other health benefits, does not appear to protect against allergic disease. December 2015

Prompt treatment with cow's milk free formula leads to clinical remission of severe FPIES in infants. December 2015

Beneficial effects of the use of camel milk in the management of children with autism:
Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder August 2013
Patient report: autism spectrum disorder treated with camel milk November 2013
Effect of camel milk on thymus and activation-regulated chemokine in autistic children: double-blind study. December 2013
Behavioral Benefits of Camel Milk in Subjects with Autism Spectrum Disorder November 2015
Nutritional and Therapeutic Benefits of Camel Milk in Children: A Systematic Review 2015

 

19th December 2015

Adherence to gluten-free diet and barriers to adherence in patients with celiac disease. November 2015

Organically grown tomatoes appear to offer little advantage over conventionally cultivated plants in terms of reduced allergenic potential. November 2015

Fish allergic patients have been generally advised for strict universal avoidance of fish. However, testing with various fish species or preparations might identify one or more forms that can be tolerated. February 2015

Cross-reactivity exists between chickpea and pea/lentil/soybean/hazelnut. Chickpea allergy is associated with lentil and/or pea allergy, but evidently may not present independently. This suggest that chickpea allergy is merely an expression of cross-reactivity, caused by pea and/or lentil as the "primary" allergen. December 2014

The Pollen-Food Olive-Olive Syndrome. May 2015

Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences. November 2015

Food Allergen Guidelines for US Producers (Prevention and Control, and Declaration through Labelling) November 2015

Current overview of allergens of plant pathogenesis related protein families. February 2014

In patients with symptoms triggered by histamine-rich food, measuring the serum diamine oxidase activity can help identify subjects who can benefit from a histamine limitation diet and/or diamine oxidase supplementation. November 2015

Season of birth shapes neonatal immune function. October 2015

Celiac disease manifest as a neurologic condition in 10% of all CD patients. The most common are cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression and cognitive deficiencies. A review. November 2015

The anti-inflammatory and anti-oxidant properties of almond milk suggest that almond milk might be considered as a potential alternative in cow’s milk protein allergy treatment. June 2015

Atopic disease is associated with chronic inflammation, food allergen avoidance, and use of systemic immunosuppressant medications. All these factors have been shown to be associated with anemia. November 2015

US allergics – beware of 'natural flavours' – they could include 'your' allergen. December 2015

Allergy awareness poor among chefs in the US. December 2015

Sesame to be considered for listing as a major allergen in the US. December 2015

In 2010 four selected chemicals (dioxin, aflatoxin, peanut allergen and cyanide in cassava) were estimated to be collectively associated with 339,000 illnesses, 20,000 deaths, and 1,012,000 DALYs - findings of a WHO Taskforce. December 2015

Children with allergic disease, particularly asthma and hay fever, have about twice the rate of high blood pressure and high cholesterol, setting them on a course for heart disease at a surprisingly early age. Comment here. December 2015

A study of more than 2,700 mothers of children with autism shows that about one in 10 mothers have antibodies in their bloodstream that react with proteins in the brain of their babies possiby causing autism.
Studies suggest that women with certain pro-inflammatory conditions—such as rheumatoid arthritis and celiac disease—are at greater risk of having children with autism. August 2015

Allergen Immunotherapy: History and Future Developments. October 2015

Novel Delivery Routes for Allergy Immunotherapy: Intralymphatic, Epicutaneous, and Intradermal. 2015

Advances in the Treatment of Food Allergy: Sublingual and Epicutaneous Immunotherapy. 2015

Oral Immunotherapy for Food Allergy - with reference to cow's milk, hen's egg, and peanut. 2015

Evaluating the impact of infant feeding guidelines on CMA prescribing in UK primary care. This study shows promising results for prospective research on a national scale, including socio-economical impact and cost-effectiveness. November 2015

 

5th December 2015

Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder. December 2015

Studies in experimental models are contributing to understand the role of intestinal bacteria and its interactions with a predisposed genotype in promoting CD. Advances in this area could aid in the development of microbiome-informed intervention strategies. November 2015

Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing. November 2015

Early feeding practices seem to have no impact on the risk of developing CD during childhood. November 2015

A review of complexity of the cereals from which gluten is derived, the special properties of gluten which make it so widely used in the food industry, the basis for its toxicity in CD patients and the potential for the development of safe gluten and alternatives to the gluten-free diet. November 2015

A review of selection methods for immunomodulatory probiotic strains and the mechanism of action of probiotics in immune modulation. 2015

In a large cohort of infants with atopic dermatitis at risk for development of food allergy, food-antigen-specific immunoglobulin E (sIgE) levels were not clinically useful for predicting food allergy development. December 2015

Exposure to Giardia infection was associated with perceived food intolerance 3 years after giardiasis. Perceived intolerance to high FODMAP foods and low FODMAP foods were both statistically significantly associated with exposure to Giardia infection. November 2015

This review summarizes the evidence on EoE pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. November 2015

By acting on intestinal and systemic immune functions, a cocoa-enriched diet in rats exhibited a protective effect against food allergy and partially against anaphylaxis, making this a food of high interest to the fields of health and immunonutrition. October 2015

Consuming a cow's milk exclusion diet during infancy has persistent and long-term effects on eating habits and food preferences. November 2015

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species. October 2015

Awareness of sesame allergies grows amid push for more accurate food labeling Novmeber 2015

Management of simple food allergy by community paediatricians in Australia appears feasible and acceptable to paediatricians and families alike. November 2015

T Cell Epitope Immunotherapy Ameliorates Allergic Responses in a Murine Model of Shrimp Allergy. November 2015

Improving the safety of oral immunotherapy for food allergy. November 2015

Consumption of certain food and natural materials such as fenugreek, skullcap, chitin/chitosan, and cheonggukjang as anti-allergics have merits such as safety (no adverse side effects), multiple suppressive effects and ease of consumption when required. 2015

It may be important to consider the diversity of food allergy in order to fight against food allergy. 2015

 

21st November 2015

Dietary vegetable oils rich in n-6 PUFA may enhance the susceptibility to develop or sustain food allergy. August 2015

The controversial role of food allergy in infantile colic: evidence and clinical management. March 2015

Probiotics may improve effectiveness of peanut oral immunotherapy. March 2015

Food the most common trigger of anaphylaxis in paediatric population but epinephrine underused and children may have several episodes before being assessed by an allergist. November 2015

There is insufficient evidence for using Oral or sublingual immunotherapy to treat allergy to fruit, specifically related to peach and apple. November 2015

Allergic mechanisms of Eosinophilic oesophagitis. October 2015

Eosinophilic Esophagitis: Another Atopy-Related Alopecia Areata Trigger? November 2015

Correlation of skin barrier impairment in atopic dermatitis with aeroallergen sensitization. November 2015

Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance. November 2015

Feeding at-risk infants gluten increases risk of developing celiac disease. November 2015

Role of oats in celiac disease: it is essential to thoroughly study the variety of oats used in a food ingredient before including it in a gluten-free diet. November 2015

Age-related differences in celiac disease: Specific characteristics of adult presentation. Novmeber 2015

Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. November 2015

In-house test kits help motivate parents to reduce allergens in their homes. November 2015

 

7th November 2015

Provision of mental health care services, not just screenings, critically important for children with food allergies. October 2015

Recent accumulated evidence suggests that exposure to allergens early in life may promote immune tolerance and contribute to prevent infant food sensitization. May 2014

Skin testing with raw egg does not predict tolerance to baked egg in egg-allergic children. November 2014

Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. August 2015

The Prevalence of Tree Nut Allergy: A Systematic Review. September 2015

Managing semen allergy. October 2015

Managing allergic disease in the elderly. November 2015

Large scale production of fecal-transplant pills initiated. October 2015

Life long gluten-free diet reduces the risk of metabolic osteopathy and joint and muscle problems and the need for analgesic drus. 2015

High levels of zonulin linked to NCGS and IBS. October 2015

The advent of next-generation assays for diagnosis may result in more sensitive screening and ultimately the possible replacement of the intestinal biopsy as the gold standard for celiac disease diagnosis. 2015

There is currently no evidence to support that early introduction of gluten to the infant diet increases the risk of CD; however, late introduction of gluten may be associated with increased risk of CD. October 2015

The Spectrum of Differences between Childhood and Adulthood Celiac Disease. October 2015

Reptiles often chosen as pets when children allergic to dogs or cats but reptiles' food can also cause lasting allergic reactions. October 2015

Significant clinical differences found between children with monosensitization and those with polysensitization to common food allergens. September 2015

Egg allergy less common than supposed and 50% of allergic children likely to gain tolerance within 1 year of diagnosis. October 2015

High prevalence of lipid transfer protein sensitization in apple allergic patients with systemic symptoms. September 2014

Oral immunotherapy for cow's milk allergy still effective after seven years. October 2015

New research suggests that in allergy the immune system mistakes the proteins in environmental allergens (such as foods or pollen) for those in parastic worms which it is programmed to attack. Reseach here; comment here. October 2015

Sublingual immunotherapy in children not only as a therapy but as a preventative measure for food and respiratory allergy. October 2015

 

24th October 2015

Researchers find that polyamines, moving through a potassium channel, can transmit electrcial signals into the cell thus allowing us to 'sense' and react to electric fields. October 2015

Coeliac Disease – Recognition, Assessment and Management
NICE Guideline, No. 20. 2015

Can genetic background alone explain the association between coeliac disease and autoimmune diseases or should gluten-related factors be considered? October 2015

Second hand tobacco smoke exposure in infancy appears to increase the risk of sensitization to food allergens as well as eczema up to age 16 years. October 2015

Allergenicity of fish is considered to correlate with the content of parvalbumin and large-sized migratory fish, such as salmon, swordfish and tuna, were commonly very low in both parvalbumin content and IgE reactivity. August 2015

Roasting walnuts does not appear to reduce their allergenicity. September 2013

Review of the human gastrointestinal microbiome, focusing on the theory and evidence for its role in the development of IgE-mediated food allergy and other allergic diseases. September 2015

School Food Allergy and Anaphylaxis Management for the Pediatrician—educating the family to partner with their schools and encouraging the school to provide reasonable and effective accommodations, as per state or federal guidelines. October 2015

Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. June 2015

Allergen component-resolved diagnostic testing (CRD) is a new methodology in clinical food allergy diagnosis, improving the ability to identify specific clinical phenotypes and identifying of specific molecules causing sensitization or allergy. June 2015

How oral food challenges may be designed to assess specific characteristics of the food allergic response. August 2015

Why Does Australia Appear to Have the Highest Rates of Food Allergy? September 2015

Management of Eosinophilic Esophagitis in Adults. October 2015

New-onset food allergy recognised as one of the complications after liver transplantation, especially in pediatric patients. October 2015

Primary immune deficiencies (PIDs) are an uncommon heterogeneous group of diseases that result from fundamental defects in the proteins and cells that enable specific immune responses and can be masked by common allergic reactions. But immune suppression with systemic corticosteroids can be life threatening. September 2015

Primary prevention of allergy: will it soon become a reality? Three interventions discussed. October 2015

The combined presence of schizophrenia and atopic diseases is associated with an increased risk of ischemic stroke in later life. October 2015

Sterilisation with Essure may cause problems for those who are nickel sensitive. October 2015

 

10th October 2015

Wheat-Dependent Exercise-Induced Anaphylaxis. September 2015

Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. September 2015

Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources. June 2015

Data indicate that many adult Australians are consciously avoiding consumption of wheat foods, predominantly without any formal diagnosis. Reported symptoms suggest a physiological but not allergenic basis to this behaviour. February 2015

Accurate food adverse sensitivity documentation in electronic health records (EHRs) is crucial to patient safety. This study examined, encoded, and grouped foods that caused any adverse sensitivity in a large allergy repository using natural language processing and standard terminologies. September 2015

Hydrolyzed whey protein prevents the development of cow's milk allergy in sensitized mice. September 2015

Hypersensitivity to major panallergens in a population of 120 patients. August 2015 (For more on panallergens see here.)

Peanut avoidance and peanut allergy diagnosis in siblings of peanut allergic children. January 2015

Immunoreactivity of lactic acid-treated mare's milk after simulated digestion. Febraury 2015

Maternal diet and its influence on the development of allergic disease. January 2015

A review of the evidence linking eosinophilic esophagitis and food allergy. Jan-February 2014

Although peanut allergy is among the most common food allergies, no study has previously comprehensively described the epidemiology of the condition among the general pediatric population. Jan-February 2015

Patch testing for food allergy: the data, in particular the sensitivity, specificity, and predictive values, vary widely from 0 to 100%, depending on the study so food APT use in isolation is not recommended at this time. Decemebr 2014

Alioidea allergic reactions (to onions and garlic) overview. In the last ten years, the world production of onions and garlic has increased of at least 25% and their growing use is producing more and more specific and sometimes serious medical conditions. 2014

30 – 75% of those with hay fever may have oral allergy syndrome caused by raw fuits and vegetables, but symptoms can be avoided with cooking. September 2015

 

26th September 2015

Central America in Transition: From Maize to Wheat. Challenges and Opportunities 2015

Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis. September 2015

Alexithymia (the sub-clinical inability to identify and describe emotions in the self resulting in poor emotional awareness, social attachment, and interpersonal relating) higher in food-allergic versus healthy children and young adults. September 2015

FODMAPS diets hold great promise in treating IBS patients in East and Southeast Asia. This review highlights how the diet is implemented, its efficacy, and troublesome ingredients frequently used in Asian dishes. September 2015

Consensus Communication on Early Peanut Introduction and Prevention of Peanut Allergy in High-Risk Infants. September 2015

Epidemiology of anaphylaxis. Could Vitamin D exposure be relevant? September 2015

Instances of anaphylaxis doubles over seven years in Ontario, Canada. September 2015

Food-allergic schoolchildren have a probability of being bullied approximately 2 times higher than healthy peers, in an Italian study. September 2015

Instance of FPIES to fish. September 2015

Dogfish appears to be tolerated by children with fish allergy. September 2015

Turmeric, including various components, may be useful to ameliorate Th2-mediated allergic disorders such as food allergy, atopic dermatitis, and asthma. April 2005

Carrageenan, which causes both raised blood sugar levels and inflammation in animals, is found in sufficient quantities in most western diets to cause similar results in humans. September 2015

Recent studies on correlations between food allergies and intestinal barrier functions, and intestinal barrier function injury summarized to provide reference for laboratory researches and clinical treatment. April 2015

Cow's milk allergy and neonatal short bowel syndrome: comorbidity or true association? September 2013

In a small, preliminary study, infants in households with furry pets were found to share some of the animals’ gut bacteria - possibly explaining why early animal exposure may protect against some allergies. September 2015

Swiss researchers suggest that it might be possible to control allergic reactions by creating T-regulatory (Treg) in the laboratory which could be injectd into the allergy sufferer. Comment here; original research here. September 2015

Key enzyme, A20, helps country kids ward off allergies and asthma. September 2015

 

11th September 2015

Validation of a set of clinical and endoscopic features to predict EoE with a high degree of accuracy and allow identification of those at very low risk of disease. September 2015

Anaphylaxis is underdiagnosed in emergency departments. August 2015

Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy. August 2015

Food sensitisation prevalence is highest in infancy and declines after 12 months of age. Food sensitisation at 12 months can predict children at greater risk of adolescent sensitisation and probable food allergy at 12 and 18 years. August 2015

The OIT protocol was safe and effective in inducing egg desensitization. April 2015

A Web site-based reporting system for monitoring home treatment during oral immunotherapy for food allergy. May 2015

BDA Policy statement on gluten-free food on prescription. September 2015

Sodium Cromoglycate prevents exacerbation of IgE-mediated food-allergic reaction induced by Aspirin in a rat model of egg allergy. August 2015

Scientists elucidate the role of a key molecule involved in eosinophilic esophagitis (EoE). August 2015

Guidance on the early introduction of peanut to at risk infants based on the results of the LEAP study. September 2015

Researchers successfully establish a causal relationship between exposure to so-called farm dust and protection against asthma and allergies. September 2015

Susceptibility to allergies reduced by increased production of regulatory T cells. September 2015

 

28th August 2015

US Government study finds that 65% of breast milks sampled contained artifical sweeteners. August 2015

From genetics to treatment of eosinophilic esophagitis. October 2015

Cow's milk allergy was observed frequently in children with resistant to pharmacologic treatment of GERD. Combined skin prick and specific IgE tests, atopy patch test and oral food challenge is essential for avoidance of unnecessary elimination diet. August 2015

Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model. June 2015

Traces of ovalbumin and casein detected in white and red wines by quantitative western blotting. August 2015

An insight in to egg hypersensitivity. August 2015

Hypersensitivity to Tomato in Peach-Allergic Patients: rPrup 3 and rPrup 1 Are Predictive of Symptom Severity. 2015

Feeding difficulties in children with food protein-induced gastrointestinal allergies. October 2014

Allergy Therapeutics use a novel proteomic approach to understand the molecular fingerprint underpinning the causative agents of leading causes of allergy. August 2015

Carboxymethylcellulose and polysorbate-80- induced gut microbiota alteration and gut barrier dysfunction in mice, resulting in weight gain, low-grade inflammation, and metabolic disorders. August 2015

Recent studies on correlations between food allergies and intestinal barrier functions. April 2015

Low vitamin D-binding protein levels increase risk for food allergy. August 2015

FPIES caused by fish and/shellfish in Italy. August 2015

Immunisation with shrimp allergen inhibits allergic reactions. November 2014

Nitrogen dioxide air pollution increases allergenicity in ragweed pollen. August 2015

 

15th August 2015

Does a low FODMAP diet help IBS? August 2015

Exchanging melamine for stainless steel food containers could dramatically reduce the amount of the potentially harmful melamine ingested. August 2015

Systematic review of tree nut allergy suggests that Brazil nut, almond and walnut allergy are most preavanlent in the UK, hazelnut in Europe and walnut and cashew in the US. September 2015

Three month course of oral egg immunotherapy appears to achieve tolerance in egg allergic children. August 2015

The majority of food allergic children who passed an oral food challenge subsequently ate target food regularly and their family's quality of life improved. Adverse reactions were rare and never serious. August 2015

Histamine, histamine intoxication and intolerance. August 2015

Seafood Allergy, Toxicity, and Intolerance: A Review. August 2015

Even if severe allergic reaction is in doubt, epinephrine should be used. August 2015

There is a substantial disagreement between SPT and sIgE for diagnosing allergic sensitization in young children, which increases with age for food sensitization. November 2014

Ara h 2- and Cor a 14-specific IgE are useful to estimate the probability for a positive challenge outcome in the diagnostic work-up of peanut or hazelnut allergy making some food challenges superfluous. November 2014

IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome. November 2014

New developments in allergen immunotherapy. August 2015

Eating oily fish may help kids avoid nasal allergies. August 2015

Detecting hidden ingredients in dietary supplements and medications. August 2015

31st July 2015

Significant relationship observed between peach and symptoms of tomato allergy. IgE positivity for rPru p3 seems to be a surrogate biochemical marker for severe tomato allergy, whereas the presence of anti-rPru p 1 IgE may be an indicator of mild tomato allergy. 2015

Barnacle hypersensitivity. March 2002

Because pine nut is commonly consumed in our environment, the prevalence of allergic reactions is probably considerable and these reactions take place at an early age. Common antigenic proteins are also shared between pine nut and peanuts. March 2002

The chances of having a food allergy are significantly higher if you were born in the autumn or winter while there is a strong negative correlation between the amount of solar radiation the infant is subject to immediately after birth and allergen sensitisation. July 2015

Recognition pattern of kiwi seed storage proteins in kiwifruit allergic children. July 2015

Study identifies a risk of dun pea (a relation of the green pea recently introduced into food manufacture) allergy in legume-allergic patients and in a subset of peanut-allergic patients. NB Legume allergy is the fifth food allergy in Europe. July 2015

Hospitalisation rate for potentially fatal allergic reactions has almost tripled in Australia over the past 13 year. July 2015

Biotin and carnitine deficiency due to hypoallergenic formula nutrition in infants with milk allergy. April 2014

Increased intake of vegetable oil rich in n-6 PUFA enhances allergic symptoms and prevents oral tolerance induction in whey-allergic mice. July 2015

Doctors warn common food allergy tests may not identify all cases in children. July 2015

Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort. May 2015

Regular consumption of oily fish and dietary long-chain n-3 PUFAs in childhood might decrease the risk of rhinitis, especially NAR, between the ages of 8 and 16 years. July 2015

Researchers use egg yolks to create supplement that could improve lives of people with celiac disease. July 2015

Baked milk oral immunotherapy effective in only 21% of baked milk allergic patients. July 2015

82% of children who completed the six-month induction phase of oral immunotherapy to milk were able to consume at least 200ml of milk or 6,400mg of milk protein a day and after the two-year maintenance phase, half were consuming milk daily. July 2015

A review of the relationship between cow's milk allergy and epileptic seizures. November 2014

Fish allergics may react to omega-3 supplements based on fish oils. October 2014

Acutely rice-allergic FPIES child reacted to rice dust on a wrapper which had coverd a rice cake. May 2013

Hazelnut allergy differs between children and adults with respect to frequency of severity, aetiology and relevance of diagnostic parameters. December 2014

Suppression of the immunologic response to peanut during immunotherapy is often transient. December 2014

Oral immunotherapy appeared far more effective than sub-lingual immunotherapy for the treatment of peanut allergy but was also associated with significantly more adverse reactions and early study withdrawal. May 2015

 

11th July 2015

Prospective survey shows that NCGS has a strong correlation with female gender and adult age but the prevalence of NCGS seems to be only slightly higher than that of celiac disease. May 2014

Patients with asthma are at risk for more severe reactions and are less likely to reach full desensitization during food oral immunotherapy. But most who achieve full desensitization continue to consume milk protein freely after treatment. March 2015

Molecular diagnostics should be used in a targeted manner for an accurate assessment and diagnosis of food allergy, which would also reduce the use of oral challenges, to predict severe reactions and allergy persistence. June 2015

Australian research on how food allergy affects a sufferer's and their family's quality of life. June 2015

Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soap. June 2015

Pending further scientific evidence, the concept of food allergy should be included as a possible cause of IBS, and a dietary approach may have a place in the routine clinical management of IBS. June 2015

An investigation into the relationship between intestinal parasites and different inflammatory bowel disorders. Spring 2015

Wheat allergy diagnostics in children is difficult but the accuracy of wheat allergy diagnosis may be improved by measuring IgE responses to several components of wheat. November 2014

A summary of recent data on the epidemiologic link between sunlight (UVB) and food allergy, and evidence for and against a specific role for vitamin D status. August 2015

The growing world population requires the exploration of new sustainable protein sources to ensure food security. Insects such as mealworm are promising candidates. For safety reasons, a risk assessment, including allergy risks, is needed. Since allergenicity can be influenced by thermal processing, it is highly important to take this into account. June 2015

Induction of regulatory dendritic cells by the probiotic Lactobacillus paracasei L9 prevents allergic sensitization to bovine ?-lactoglobulin in mice. June 2015

Seafood allergy in cooks is mostly characterized by a quick progressive course of disease from the start of the cooking career. The prognosis for continuance in occupation is poor and an emergency kit should be provided for life by the responsible accident insurer. October 2014

An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up. April 2014

Comparison of atopic features between children and adults with eosinophilic esophagitis. October 2014

How to predict biphasic allergic reactions in children. Children are more likely to have a repeat, delayed anaphylactic reaction from the same allergic cause, depending on the severity of the initial reaction. This study looks at the predictors for this phenomenon. June 2015

Respiratory allergy symptoms are set to worsen due to climate change, as air pollution increases the aggressiveness of pollen particles and extends the reproductive season of plants. June 2015

Fecal microbiota transplantation - something more than merely a therapeutic curiosity. An as yet unedited manuscript that has been accepted for publication suggesting that FMT is a potential therapy for a wide range of conditions from ulcerative colitis and type 2 diabetes to autism and Parkinson's disease. July 2015

The wheat proteins and molecules produced during digestion of bread and pasta can survive digestion and potentially pass through the gut lining suggesting that they could have a biological effect. Previous research has been done on pure gluten rather gltuen-containing foods. July 2015

A review of the most recent findings on Non Celiac Gluten Sensitivity and directions to dissipate some of the confusion related to this disorder. May 2015

Spouses & relatives of celiac disease patients at risk for autoimmune diseases. July 2015

Researchers at the Univeristy of Oslo suggest that coeliac disease is caused by the T-cells of those genetically predisposed to suffer from coelaic disease mistaking gluten for a virus and initiating an immune reaction. June 2015.

The association between primary IgE sensitization with respiratory symptoms to inhaled allergens and food allergy due to cross-reactive allergen components is important to assess in allergy practice. The use of molecular-based diagnosis improves the understanding of clinically relevant IgE sensitization to cross-reactive allergen components from aeroallergen sources and foods. June 2015

Investigation into the allergic properties of soya beans, the mechanisms of soya bean allergy, prevention and treatment, and effects of plant breeding on the soya bean's allergenicity. June 2015

Allergic acute coronary syndrome (Kounis syndrome). July 2015

Genetic modification of wild Elstar apples resulted in the 'silencing' of their Mal d 1 gene expression and resulting in fewer symptoms in apple allergic patients. July 2015

A very low dose oral food challenge allows some low dose reactive Cow's milk allergic children to change from complete avoidance to partial intake of cow's milk. May 2015

Adrenaline/epinephrine in injector pens can survive freezing. July 2015

The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotics-treated mice model. June 2015

Supplementation of mice with Specific Nondigestible Oligosaccharides during pregnancy or lactation leads to diminished sensitization and allergy in the female offspring. April 2015

Some immunological disturbances caused by repeated exposure to the faeces of two house dust mite species in the valley and desert houses could be ameliorated by curcuma and karkade. May 2015

Immunotherapy tablets for hayfever offer little benefit compared to injectable immunotherapy. July 2015

20th June 2015

High proportions of people with non-celiac wheat sensitivity have autoimmune disease or anti-nuclear Antibodies. May 2015

Oral immunotherapy to egg results in severe eosinophilic esophagogastroenteritis in 9 year old boy. February 2015

Systematic review of 42 research papers did not find widespread or consistent links between mothers' dietary intake and atopic outcomes in their children. December 2014

Extensively hydrolysed rice infant formula good substitute for cow's milk for CMA infants. September 2014

200 scientists warn of the dangers of non-stick cookware and other household products using perfluorinated chemical (PFAS). A report on theDr Mercola site. June 2015

Gluten sensitivity does not appear to be relevant in wheat-dependant-exercise induced anaphylaxis. September 2014

Could rise in the incidence of celiac disease have been caused by the extensive use of the chemical glyphosphate on wheat crops? November 2013

Iodine deficiency a risk for children with severely restricted diets. June 2015

Omega 3 fatty acids may have a role in controlling intestinal allergies. June 2015

Laboratory test suggest that fermentation can significantly reduce the allergenicity of soy products although this now need to be tested inhuman challenge studies. May 2015

Transgenic rice developed with significantly lower levels rice allergens. December 2014

Because egg-allergic children so often 'grow out of' their allergy, they should be challenge tested regularly so that egg can reintroduced when appropriate but challenges are expensive and risky. June 2015

Environmental factors such as smoking, breastfeeding, antibiotic exposure, animal exposure etc not found to be relevant in the development of Eisinophilic Esophagitis. June 2015

Eosinophilic gastroenteritis and colitis increasingly frequent in paediatric patients. June 2015

Lactose tolerance first developed in the Bronze age. June 2015

Food additives more harmful in combination. Long report on the Dr Mercola site on the possibly harmful effects of small amounts of food additives used in combination. June 2015

 

6th June 2015

Sharing your microbiome with your pooch! Research suggests not only that we share much of our microbial populations with our dogs but that close relations with a dog can have a beneficial effect on our chances of getting an allergy as a child and and improve our health in old age... May 2015

Identifying which type of autism might respond best to helminthic therapy. May 2015

Canadian researchers develop inhibitor peptide (STAT6-IP) which they hope will inhibit the action of the molecule STAT6 which is important in the sensitisation of the immune sytem to allergens. They hope it will direct the immune system away from the allergic response, no matter what the allergen. Research here; comment here. May 2015to be

Leading allergists call for 'a more active approach to management to be adopted, which includes early introduction of potentially allergenic foods, anticipatory testing, active monitoring, desensitisation to food allergens and active risk management'. November 2014

Are children and adolescents with food allergies at increased risk for psychopathology? October 2015

Restricted diets improve symptoms in 4 weeks in non-IgE mediated gastrointestinal food allergies. May 2015

High consumption of peanuts or tree nuts by non-allergic mothers around the time of pregnancy may reduce the risk of nut allergy in the child. April 2015

Human milk oligosaccharides (2' Fucosylactose or 6' Sialyllactose) may have therapeutic potential in allergic disease. May 2015

Even when the children have outgrown their cow's milk allergy, families still have nutritional concerns and should be offered dietary advice to encourage progression to unrestricted diet, prevent eating disorders and impaired growth. May 2015

Do mothers mistake symptoms of undiagnosed cow's milk allergy in infants for a child just 'being difficult'? May 2014

Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap in Japan. August 2014

55% of top selling probiotics in US have detectable gluten traces. May 2015

Perception of lactose intolerance in irritable bowel syndrome patients. October 2014

 

23rd May 2015

Exposure to traffic-related air pollution in the first year of life increases the risk of developing allergies to food, mould, pets and pests. May 2014

Researchers in Oslo show that allergen-specific T cells are resident in the mucosa outside the pollen season and react strongly to pollen extract, suggesting that these T cells are long-lived resident memory cells. This suggests that anti-inflammatory seasonal hay fever therapy should be initiated prior to season. May 2015

Researchers create new soybean with significantly reduced levels of three key proteins responsible for both its allergenic and anti-nutritional effects. Research here; comment here. April 2015

Unlike soyabean proteins, germinated soybean proteins do not appear to provoke serious allergic reactions. May 2015

Could there be a cross reaction between jack fruit and latex? March 2015

Oral Immunotherapy safe and effective in inducing egg desensitization. April 2015

Mannitol as an excipient in rhinitis drug causes immediate allergic reaction. May 2015

Type 1 diabetes pathogenesis - Prevention???
"The putative predisposing factors are viruses (enteroviruses and rotaviruses) and components of infant diet including gluten and cow's milk. The putative protective factors are gut flora, helminths, viral infections, and sunlight (Vitamin D)"

The horse immune system can respond to midge bites in a way that prevents - rather than triggers - allergic reactions. Edinburgh researchers believe that this reaction could be adapted to prevent allergies in humans. April 2015

Connection between dry eye and seasonal allergies. April. 2015

Pre-existing inflammation from allergic reactions may set the stage for cancer to spread from one area to another. April 2015

Allergies can, rarely, be passed thorugh blood transfusions. Research here and here. April 2015

Canadian study finds that children who are allergic to peanuts suffer 37% of reactions in their own homes; 14% in other people's homes, 4.9% in schools where peanus are forbidden and only 3% in schools where they are allowed. April 2015

 

9th May 2015

Immune reactivity to food coloring. Vojdani 2015

Molecular mimicry as a mechanism for food immune reactivities and autoimmunity. 2015

Oral tolerance and its relationship to food immunoreactivities. Professor Vojdani explains. 2015

Improvement in psychotic symptoms in a boy with complex autoimmune illness after a gluten-free diet. March 2015

Should anyone showing signs and symptoms of the Coeliac Disease be tested and should screening everyone in high-risk groups be considered? April 2014

The genotype of infants at family risk of developing Coeliac Disease, carrying the HLA-DQ2 haplotypes, influences the early gut microbiota composition. This finding suggests that a specific disease-biased host genotype may also select for the first gut colonisers and could contribute to determining disease risk. June 2014

Food protein allergen characterization and quantification, together with the immunoglobulin E epitope mapping, will contribute to the diagnosis/prognosis of food allergy and will lead to a better safety assessment of foods (e.g. novel transgenic foods). April 2015

Sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. September 2014

Professor Aristo Vojdani discusses the history of food testing, analyzes the criticisms of it, reviews the scientific literature, and tours the methodologies. 2015

To improve the accuracy of skin prick tests in diagnosing food sensitivy the quality of the food extracts needs to be improved and both IgE and IgG needs to be measured. 2015

The composition of gut microbiota does not seem to be significantly different between atopic and healthy children, but lower abundance and prevalence of Akkermansia indicate that this bacterium may accompany or play a role in IgE-mediated atopic diseases. April 2015

Dendritic cells which switch on inflammation againt parasitic wroms and allergies controlled by the protein Mbd2. This discovery may enable better targeting of medicine sot combat inflammation. April 2015

25th April 2015

Fascinating interview on Mosaic with immunology professor Ruslan Medzhitov of the Yale University of Medicine who theorises that far from being damaging, allergies are actually protective. April 2015

Humans, dogs, cats and horses suffer from similar environmental allergies and immunotherapy seemstot be equally successful in all species. April 2015

Safety and clinical predictors of reacting to extensively heated cow's milk challenge in cow's milk-allergic children. October 2014

Breast milk sold online may contain cow's milk. April 2015

Transfer of peanut IgE sensitisation after combined pancreas-kidney transplant. August 2014

Blood test could predict severity of peanut and seafood allergies. April 2015

Researchers in Madrid and France have developed super sensitive NIR spectroscopy (an analytical technique that detects specific molecules based on their absorption and reflection of light at near infrared wavelengths) which enables them to detect trace levels of peanut over a large area. This would allow manufacturers to test for trace levels of peanut and establish their concentration, thus obviating the need for defensive may contain warnings. They hope to develop the technique for other nuts. Research here. April 2015

Food allergies can be transmitted from blood products to children in rare cases. April 2015

Fears over Roundup herbicide residues prompt private testing. April 2015

Combining a probiotic with peanut oral immunotherapy shows promise. Research here. January 2015

Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. November 2014

Lower bifidobacteria counts in adult patients with celiac disease even on a gluten-free diet. June 2014

 

11th April 2015

Early, aggressive treatment of patients with infantile atopic dermatitis significantly reduces food allergy incidence by 18 months of age. February 2015

Nasal-spray flu vaccines appear to be safe for children over age two who have egg allergies or asthma. February 2015

Downregulation of angiogenesis factors, VEGF and PDGF, after rapid IgE desensitization and oral immunotherapy in children with food allergy. Jnen 2014

Researchers pinpoint a region in the human genome associated with peanut allergy but warn that there may be other molecular mechanisms that may contribute to whether those who are genetically predisposed to peanut allergies actually develop them. Februry 2015

Peanut 'patch' show promise in the treatment of peanut allergy. February 2015

Infants with a milk protein intolerance should be treated for 2 to 3 months with a hypoallergenic formula, then rechallenged at 6 months. Rechallenging before 12 months could result in cost savings. August 2014

Food allergens affect the intestinal tight junction permeability in inducing intestinal food allergy in rats. December 2014

Allergies can be to cooked as well as, or instead of, to raw legumes. March 2015

'May contan' labelling agreed to be counter-productive for consumers with food allergy. Precautionary allergen labelling (PAL) should reflect actual risk and consumers with food allergy then need to be educated to undertake individualised risk assessments in relation to any PAL present. March 2015

The role of food allergy in infant colic is still unclear. However, where there is a suspicion of food allergy, a short trial with an extensively hydrolyzed cow's proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option. March 2015

Extensive cross reactivity at T cell and antibody level was observed in mouse models among Ara h 1, 2, 3 and 6 (peanut proteins), which may have important implications for the diagnosis and therapy of peanut allergy. March 2015

Molecular diagnosis shows promise in allergy diagnosis. It provides information on allergenic components at the molecular level, allowing better understanding of symptoms and patient adjusted procedures. June 2014

Rush OIT (oral immunthotherapy) appears to be effective and relatively sfe for children with severe peanut allergy. June 2014

Nineteen our of 364 proteins in breast milk different in the milk of allergic and non-allergic mothers with the allergic mother's having higher concentrations of proteins linked to asthma and allergy. March 2015

28th March 2015

Allergenic non-gluten proteins can be lost in boiling process although not in baking suggests that those with non-coeliac wheat allergies might be able to eat boiled pasta but not baked. March 2015

Dogs as probiotics. Researchers at the University of Arizona are recruiting for study of the threapeutic possibilities of the biological connection between humans and dogs that could be shared through saliva, skin, and even faeces. March 2015

Benefits of an integrated approach by food allergists, gastroenterologists, and pathologists in themanagement of Eosinophilic esophagitis. August 2014

Study identifies reduced early diastolic tissue Doppler velocities in infants with cow's milk allergy. August 2014

Three month old infants with low microbiotic richness in their gut and an imblance of gut bacteria have an increased likelihood of developing food sensitisation at 12 months. March 2015

Epidemiologic survey in Japan showed that the hygiene hypothesis and intestinal bacterial flora might influence the development of symptoms and remission of allergic diseases. March 2015

Air pollutants could boost potency of common airborne allergens. March 2015

University of Huddersfield uses mass spectrometry analysis to identify the molecular compostion of foods enabling them to identify original ingredients – such as whether gelatine was made from beef or pork or whether an ingredient has been derived from an allergen. March 2015

Allergy to rabbit meat after sensitization by inhalation. 2014

Danish researchers establish that multiple chemicals in foods (pesticide residues etc) have an additive, 'cocktail' effect greater than that of each individual chenical. Traditionally harm has been assessed only on the harmful effect of each individual chemcial. March 2015

Study suggests that coeliac disease is significantly more common among white Americans than among Hispanics and African Americans although the latter are very likely to adopt a gluten-free diet. March 2015

 

 

14th March 2015

Growth screeniing could help detect coeliac disease in children. March 2015

Use of antibiotics in pregnancy linked with increased risk of asthma by the age of three. March 2015

Anaphylactic allergic reaction to gelatine in a cold medication in Japan. November 2014

Could prenatal stress affect the microbiota of the infant? January 2015

Could the lack of fibre in modern diets be significant in the rise in allergic disease? March 2015

Food allergy and eczema, occurring early in life might be an early warning sign of Primary immunodeficiency diseases. If associated with recurrent infections, clinicians should pursue an immunologic evaluation. January 2015

Concern, in the light of the new peanut allergy prevention research, that parents might now feed whole peanuts to small children. March 2015

A more advanced and much more sensitive test for peanut allergy under development. March 2015

Pitfalls in Food Allergy Diagnosis: Serum IgE Testing. Helpful guidance from Drs David Fleischer and Wesley Burks. January 2015

Although still relatively uncommon, allergy to C sativa/marijuana is being reported with increased frequency. January 2105

Could prenatal and postnatal supplementation of bifidobacteria be effective in primary preventing allergic diseases? July 2014

Could abnormal intestinal microbiota be associated with persistent gastrointestinal symptoms in gluten-free celiac disease patients? Feburary 2015

FDA does not accept the causal link between certian food additives and ADHD. 'More research is needed'. March 2011

Energy drinks significantly increase hyperactivity in schoolchildren. February 2015

Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases. February 2014

Role of cellular immunity in cow's milk allergy: pathogenesis, tolerance induction, and beyond. June 2014

 

28th February 2015

Early consumption of peanuts can protect against allergy. The results of the LEAP study. February 2015

Enzyme can reduce sulphites in wine. Research here; comment here. February 2015

Researchers from CNRS, INSERM and Université de Limoges have shown that the body restricts the production of IgE in order to prevent allergic reactions. February 2015

Researchers at Imperial College, London, looking at epigenetic changes have discovered 30 new genes which predispose to allergy and asthma. February 2015

Increasing evidence for using a low FODMAP diet in the management of functional gastrointestinal symptoms where food intolerance is suspected December 2014.

DHA-rich tuna oil effectively suppresses allergic symptoms in mice allergic to whey or peanut. October 2014

Young adults with cow's milk allergy have poor bone density. August 2014

Four-food group elimination diet successful for adult eosinophilic esophagitis. August 2014

Role of cellular immunity in cow's milk allergy: pathogenesis, tolerance induction, and beyond. June 2014

Broad bean proteins have the ability to elicit allergic responses due to the presence of clinically relevant allergenic proteins. December 2013

 

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