Pre and probiotics

Please click on the links below to read our articles. If you are interested in research findings, click here for links to research reports.

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Can taking probiotics help a histamine intolerance? Dr Joneja is not convinced. February 2016

Overview of the use of probiotics in paediatric allergy. Castellazzi et al. Italian Journal of Pediatrics 2013.

The key to successful use of probiotics is to match the strain to the condition they are treating. Useful article on Natural Health Advisory. May 2013 A good blog for anyone interested in probiotcs and the science of gut bacteria.

Can probiotics prevent food allergy? Interesting post on YesNoBananas blog. 01/13

Useful glossary of probiotic terms on the OptiBac site. November 2012

Two articles suggesting that probiotics may affect gut metabolism and might possible affect gene expression. 10/11

Practical use of Probiotics and Prebiotics. A useful article in the July 2011 Townsend Letter by Drs Stephen Olmstead, Dennis Meiss and Janet Ralston of Pro Thera Inc.

Probiotics, Prebiotics and Fibre – The Three Bowel Musketeers! Micki Rose elaborates. October 2010

Babies need friendly bugs – John Scott explains why
August 2010

Probiotics – the 'friendly' bacteria: side-lined healers – John Scott reviews the current research. Febuary 2010

Probiotics and autism: reporting an experiment on autistic children and probiotics that was so successful it collapsed – John Scott 2007

Probiotics as a mainstream therapy? A conference investigating the possible use of probiotics to bring about an improvement in intestinal and systemic disease – Dick Mieli 2007

First Published in 2007

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Research Reports

Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial. August 2017

This study presents some very promising results showing long-term benefits of peanut oral immunotherapy, combined with a probiotic, for many patients. The original research demonstrated that combined probiotic and peanut immunotherapy induced sensitisation in a significant proportion of participants (using a randomised, double-blind, placebo-controlled trial). This follow-up study demonstrates that, 4 years after this intervention treatment ended, many participants were still experiencing positive immune system effects, such that they were able to safely consume peanuts. 67% of the treatment group had continued to eat peanuts, compared to just a single participant (4%) from the control group who did not receive the treatment. Whilst not all participants benefitted from this treatment, the high proportion of responders is very exciting and suggests more research is needed into this combined therapy, which has the potential to make a huge difference to the quality of life of many food allergy sufferers. 

Probiotics in Asthma and Allergy Prevention. July 2017

This review study outlines that probiotics are often used in an attempt to prevent the development of allergy but that there still a limited amount of evidence to back this up and much more research is required in this area.

Probiotic influences on allergic responses in mice. May 2017
This study explored the influence of lactic acid bacteria probiotics on allergic responses in mice. It was found that Bacillus coagulans was the most effective probiotic anti-allergenic strain and some of the mechanisms behind how this may work are explored. Read the full article.

Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models. March 2017
This research looked at the influence of a probiotic (Bifidobacterium) on allergic inflammation in response to egg allergens in mice. This probiotic was found to inhibit the production of IgE (important in the allergic response) and to reduce allergic inflammation. This suggests a potential way of reducing allergic responses in humans and warrants further study.

Dietary interventions for recurrent abdominal pain in childhood. March 2017
Treating recurrent abdominal pain in children, where no known cause for the symptoms can be identified, is a tricky matter. Here authors review 19 studies of interventions in such children, in order to see which treatments seem to be the most successful in reducing pain. They find some evidence to support the use of probiotics in such children as being beneficial for pain reduction. There was a scarcity of studies looking at exclusion diets, including the low FODMAP diet, which are much needed in this age-group.

Review of the effects of fermented milk with healthy bacteria on gastrointestinal discomfort in the general adult population. Jan 2017
Similar to the above study on children, this review identifies small, but consistent improvements in abdominal pain in adults with gastrointestinal discomfort when treated with probiotics, in this case fermented milk with Bifidobacterium lactis (B. lactis) CNCM I-2494 and lactic acid bacteria. (Full text available).

Pre- and probiotics for allergy prevention: time to revisit recommendations?
October 2016
‘Recent guidelines from the World Allergy Organization recommend the use of probiotics for the primary prevention of eczema in pregnant and breastfeeding mothers of infants at high risk for developing allergy and in high risk infants.’ Probiotics are a source of beneficial bacteria that are introduced into the gut through oral consumption. This article discusses some of the issues around our current understanding of the research informing this advice.

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals
November 2016

Great review article about the influence of probiotics and prebiotics on brain function, emotion and thinking. Probiotics (beneficial gut-bacteria) and prebiotics (which feed the bacteria) are being increasingly investigated regarding their role in allergy prevention and treatment. It is interesting to note that there is also increasing evidence that these friendly bacteria are involved in brain function and mental health. This article reviews both animal and human research which suggests that manipulating gut bacteria, to increase the number and activity of beneficial bacteria, improves cognitive function and mood. Pro-biotics appear to achieve similar results to some anti-depressants for example, in terms of improving mood and reducing anxiety. The potential for using such supplements for treating mental health conditions is immense.

Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties. October 2016
This is an animal study, which looks at the effects of probiotics in mice. It was found that probiotics were able to reduce allergic airway inflammation in mice. Results such as these are exciting, as they suggest potential future treatments that may be able to be applied to humans.

Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics.
Grossi E, Melli S, Dunca D, Terruzzi V.
This reports a case-study of a single patient with autism and coeliac disease. Treatment with probiotics reduced severity of abdominal symptoms but, interestingly, also led to an improvement in autistic symptomatology.

A review of selection methods for immunomodulatory probiotic strains and the mechanism of action of probiotics in immune modulation. 2015

Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide. August 2013

Identifying anti-allergic probiotic strains. May 2013

Meta analysis of clinical trials finds that probiotic administration reduces the risk of atopic sensitization and decreases the total IgE level in children but may not reduce the risk of asthma/wheeze. August 2013

Cochrane Collaboration finds that probiotics are effective for preventing Clostridium difficile diarrhea often associated with antibiotic use. May 2013

The addition of a probiotic formula to triple H. pylori eradication therapy significantly decreased the frequency of epigastric pain, nausea, vomiting and diarrhea. October 2012

Prebiotics for intestinal failure improve gut – March 2012

Probiotics may contain hidden food allergens – September 2012

Selected probiotics may have a role in the prevention/management of IgE-associated allergic eczema. September 2012

Lactobacillus GG administered at the second trimester of pregnancy reduced the severity of maternal allergic disease, but not the incidence of childhood allergic sensitisation or allergic diseases. 09/12

Protective effect of probiotics shown to last at least two years – July 2012

Allergy protection from probiotics in breast milk varies for each child –June 2012

Probiotics prevent development of allergies –May2012

Two reports on probiotics and reduction of symptoms of atopic dermatitis –July 2011

Addition of lactose to hydrolysed infant formula for cow's milk allergic infants may boost their typically low levels of Bifidobacterium and Lactobacilli while reducing their typically high levels of Clostridium. March 2012

Probiotics in early life continue to lower the risk for eczema and rhinoconjunctivitis until at least 4 years of age.Febuary 2012

Probiotics are an effective treatment for antibiotic-related diarrhoea

Four different studies suggest that probiotics may be effective as inflammaotry agents and in combating antibiotic-associated diarrhoea. October 2011

The anti-allergic effect of kefir Lactobacilli
October 2010

Eating probiotics can have a beneficial impact on the central nervous system, and depression
Febuary 2012

Bacteria reduce allergy risk in children
August 2011

>A strain of probiotic may help treat ulcers caused by Helicobacter pylori
Febuary 2011

Probiotics may prevent eczematous children developing asthma
June 2010

Probiotics for Crohns disease, colitis and colon cancer
Febuary 2011

Probiotic formula reduces stress
October 2010

Maternal consumption of probiotics dramatically reduces the incidence of eczema in children July 2010

Probiotic found in breast milk could help with digestive disorders
June 2010

Antibiotics depress immune system making way for secondary infections.
Febuary 2010

Probiotics may help with chronic fatigue
May 2009

Probiotics used instead of antibiotics to treat disease
April 2009

Probiotics, prebiotics and enzymes: symposium report(April 2009

Probiotics may help irritable bowel
April 2009

Probiotic strain effective in improving irritable bowel syndrome symptoms
April 2009

Probiotics may help control diarrhoea in people taking antibiotics thus allowing them to complete their full course of antibiotic therapy.
December 2008

'Friendly' bacteria protect against Type 1 diabetes
November 2008

Probiotics may benefit Crohn's disease patients
November 2008

Benefits of probiotics reviewed
November 2008

Health benefits of probiotic could extend to the entire body according to new study
September 2008

What are probiotics?
March 2008

Probiotics may be an effective substitute for growth promoting antibiotics in pigs, giving us safer pork products
September 2007

Probiotic treatment may limit eczema in infants
July 2007

Probiotics may help in cases of colitis
April 2007

Combating infectious disease with probiotics
June 2007

Probiotics and autism
January 2007

Pre and probiotics and UC
September 2005

First Published September 2005

Articles on probiotics

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