Human seminal plasma allergy: pregnancy after prophylactic anti-histamine treatment

Allergy to semen is rare, and severity of reactions varies from mild itch to fatal anaphylaxis. It can be treated in different ways, from abstinence and use of condoms to subcutaneous or intravenous immunotherapy of seminal fluid. Local allergic reactions can be treated with anti-histamines or creams. A woman who had given birth six months previously came to hospital reporting unexpected generalised urticaria that occurred after sexual intercourse with her husband. This lady had suffered from asthma, rhinoconjunctivitis and atopic dermatitis for ten years, and was thinking about trying to conceive another child.

The lady had a positive response skin prick test to her husband’s seminal fluid. She was treated with oral anti-histamine one hour before sexual intercourse, and did not experience any reactions. The researchers propose that prophylactic anti-histamine may be applied in seminal plasma allergy patients if systemic reactions are limited to mild and moderate generalised urticaria.

Source: Asia Pacific Allergy

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First published in October 2011

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